RK-1205-I
RK-1205-I is a protein phosphatase 2A (PP2A) inhibitor and fungal growth inhibitor. RK-1205-I inhibits PP2A activity in fungal cells, leading to the accumulation of Ser/Thr phosphorylated proteins. RK-1205-I acts as a morphoregulator and induces unique morphological changes in filamentous fungi. RK-1205-I inhibits the growth of various fungi, including Aspergillus oryzae, Aspergillus fumigatus and Candida auris. RK-1205-I can be used for the research of fungal infections.
For research use only. We do not sell to patients.
- Formula: C31H49O10P
- Molecular Weight:612.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PP2A |
RK-1205-I (Compound 1) potently inhibits the growth of various fungi (e.g., A. fumigatus, Candida spp., P. oryzae), with IC50 values ranging from 0.020 to 0.55 µM[1].
RK-1205-I (0.062-0.186 µM; 48 h) induces unique morphological changes in Aspergillus oryzae[1].
RK-1205-I potently inhibits the growth of HL-60 cells, with an IC50 of 0.2 µM[1].
RK-1205-I (0.01-10 µM; 2 h) inhibits PP2A activity and increases the accumulation of serine/threonine phosphorylated proteins in Candida albicans and HL-60 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Candida albicans SC5314, HL-60 RCB0041 cells
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Concentration:0.01, 0.1, 1, 10 µM
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Incubation Time:2 h (28 °C for C. albicans; 37 °C for HL-60 cells)
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Result:Induced accumulation of serine/threonine-phosphorylated proteins in both C. albicans and HL-60 cells across all tested concentrations.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bombyx mori Kinshu × Showa (fifth-instar larvae, 2.0 g)[1]
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Dosage:0.01, 200 µg/larva (toxicity assessment)
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Administration:i.v.; single dose
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Result:Improved silkworm survival rate significantly, with a T/C value of 1.4.
Showed no toxicity to silkworms for at least 96 h at a dose of 200 µg/larva.
Chemical Information
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Molecular Weight 612.69
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Formula C31H49O10P
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SMILES
O=C1C=CC[C@H](/C=C/[C@@](C)(O)[C@H](OP(O)(O)=O)C[C@@H](O)/C=C\C=C/C=C/COC(CCCCCCCCC(C)C)=O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RK-1205-I Related Classifications
HY-184894 Related Classifications
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