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E3 ligase Ligand-Linker Conjugates 4

" in MedChemExpress (MCE) Product Catalog:

12

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Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103604
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride
    2 Publications Verification

    VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 4 hydrochloride; E3 ligase Ligand-Linker Conjugates 7

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG4-NH2 hydrochloride
  • HY-103601
    (S,R,S)-AHPC-PEG4-N3
    1 Publications Verification

    VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4

    		 E3 Ligase Ligand-Linker Conjugates Others
    (S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    (S,R,S)-AHPC-PEG4-N3
  • HY-103615
    Thalidomide-O-amido-C4-N3
    1 Publications Verification

    Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18

    		 E3 Ligase Ligand-Linker Conjugates Others
    Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker .
    Thalidomide-O-amido-C4-N3
  • HY-103604A
    (S,R,S)-AHPC-PEG4-NH2
    2 Publications Verification

    VH032-PEG4-NH2; VHL Ligand-Linker Conjugates 4 ; E3 ligase Ligand-Linker Conjugates 7 Free Base

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG4-NH2
  • HY-128821
    cIAP1 Ligand-Linker Conjugates 4

    E3 ligase Ligand-Linker Conjugates 42

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    cIAP1 Ligand-Linker Conjugates 4 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 4 can be used to design SNIPERs .
    cIAP1 Ligand-Linker Conjugates 4
  • HY-159549
    (S,R,S)-AHPC-CO-C-Cyclohexene-Bpin

    		E3 Ligase Ligand-Linker Conjugates Cancer
    SMARCA2/4-ligand-Linker Conjugate-4 is an E3 ligase ligand-linker conjugate.
    (S,R,S)-AHPC-CO-C-Cyclohexene-Bpin
  • HY-103615R
    Thalidomide-O-amido-C4-N3 (Standard)

    Cereblon Ligand-Linker Conjugates 4 (Standard); E3 ligase Ligand-Linker Conjugates 18 (Standard)

    		 Reference Standards E3 Ligase Ligand-Linker Conjugates Others
    Thalidomide-O-amido-C4-N3 (Standard) is the analytical standard of Thalidomide-O-amido-C4-N3 (HY-103615). This product is intended for research and analytical applications. Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker.
    Thalidomide-O-amido-C4-N3 (Standard)
  • HY-176872
    SMARCA2 Ligand-Linker Conjugate-4

    		Target Protein Ligand-Linker Conjugates SWI/SNF Complex Cancer
    SMARCA2 Ligand-Linker Conjugate-4 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for SMARCA2 (HY-178414) and a PROTAC linker, which recruits E3 ligases. SMARCA2 Ligand-Linker Conjugate-4 can be used for synthesis of PROTAC SMARCA2 degrader-35 (HY-176871) .
    SMARCA2 Ligand-Linker Conjugate-4
  • HY-103601R
    (S,R,S)-AHPC-PEG4-N3 (Standard)

    VH032-PEG4-N3 (Standard); VHL Ligand-Linker Conjugates 5 (Standard); E3 ligase Ligand-Linker Conjugates 4 (Standard)

    		 Reference Standards E3 Ligase Ligand-Linker Conjugates Others
    (S,R,S)-AHPC-PEG4-N3 (Standard) is the analytical standard of (S,R,S)-AHPC-PEG4-N3 (HY-103601). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    (S,R,S)-AHPC-PEG4-N3 (Standard)
  • HY-103604AR
    (S,R,S)-AHPC-PEG4-NH2 (Standard)

    VH032-PEG4-NH2 (Standard); VHL Ligand-Linker Conjugates 4 (Standard); E3 ligase Ligand-Linker Conjugates 7 Free Base (Standard)

    		 Reference Standards E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-PEG4-NH2 (Standard) is the analytical standard of (S,R,S)-AHPC-PEG4-NH2 (HY-103604A). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG4-NH2 (Standard)
  • HY-130822
    K-Ras ligand-Linker Conjugate 4

    		Target Protein Ligand-Linker Conjugates Cancer
    K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells .
    K-Ras ligand-Linker Conjugate 4
  • HY-186147
    SGI-1776-amide-C6-acid

    		Ligands for Target Protein for PROTAC Pim Others
    SGI-1776-amide-C6-acid (Compound S4) is a Target Protein Ligand-Linker Conjugate that contains a Pim inhibitor (HY-13287) and a PROTAC linker, and can recruit E3 ligase. SMARCA2 Ligand-Linker Conjugate-4 is applicable for the synthesis of PROTAC SGI-1776-VHL-02 (HY-186146) .
    SGI-1776-amide-C6-acid

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