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Results for "

Fischeriana A

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

13

Natural
Products

Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-N0732
    Jolkinolide B
    1 Publications Verification

    		 IAP Akt Caspase NF-κB TGF-beta/Smad JAK Bacterial Apoptosis Infection Metabolic Disease Inflammation/Immunology Cancer
    Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP, cIAP1, cIAP2, and phosphorylated Akt, upregulates Smac, activates caspase-3 and caspase-9, and inhibits NF-κB, TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis, suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis. Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis .
    Jolkinolide B
  • HY-133209
    Fischeria A

    		Others Cancer
    Fischeria A is a norditerpene lactone of a new carbon skeleton, can be isolated from Euphorbia fischeriana .
    Fischeria A
  • HY-119767
    Jolkinolide A

    		VEGFR Apoptosis Cancer
    Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells .
    Jolkinolide A
  • HY-N9280
    ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide

    		Others Others
    ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide (compound 12) is a natural bioactive diterpenoid found in the roots of Euphorbia fischeriana .
    ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide
  • HY-N12428
    17-Hydroxyjolkinolide A

    Caudicifolin; Fischeriana A

    		 Others Others
    17-Hydroxyjolkinolide A (Caudicifolin; Fischeriana A) is an insect feeding inhibitor isolated from the roots of spurge. 17-Hydroxyjolkinolide A induces grain aversion in S. zeamais and T. castaneum adults, with EC50s of 631.9 ppm and 656.5 ppm, respectively.
    17-Hydroxyjolkinolide A
  • HY-N10875
    Euphebracteolatin B

    		Others Others
    Euphebracteolatin B is a nature product that could be isolated from Euphorbia fischeriana .
    Euphebracteolatin B
  • HY-N10046
    ent-17-Hydroxykauran-3-one

    ent-Kaurane-3-oxo-17β-ol

    		 Others Others
    ent-17-Hydroxykauran-3-one (ent-Kaurane-3-oxo-17β-ol; compound 7) is a kaurane-type diterpenoid that can be found in the roots of Euphorbia fischeriana .
    ent-17-Hydroxykauran-3-one
  • HY-N0732R
    Jolkinolide B (Standard)

    		Reference Standards IAP Akt Caspase NF-κB TGF-beta/Smad JAK Bacterial Apoptosis Infection Inflammation/Immunology Cancer
    Jolkinolide B (Standard) is the analytical standard of Jolkinolide B (HY-N0732). This product is intended for research and analytical applications. Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP, cIAP1, cIAP2, and phosphorylated Akt, upregulates Smac, activates caspase-3 and caspase-9, and inhibits NF-κB, TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis, suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis. Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis .
    Jolkinolide B (Standard)
  • HY-N2880
    Antiquorin

    		Others Others
    Antiquorin is a Diterpenoids product that can be isolated from the roots of Euphorbia fischeriana. .
    Antiquorin
  • HY-N19376
    17-Hydroxyjolkinolide B

    		Others Others
    17-Hydroxyjolkinolide B is a diterpenoid found in Euphorbia fischeriana Steud. 17-Hydroxyjolkinolide B exhibits bioactivities .
    17-Hydroxyjolkinolide B
  • HY-N1897
    4-Hydroxy-11,12,13-trinor-5-eudesmen-7-one

    		Others Others
    4-Hydroxy-11,12,13-trinor-5-eudesmen-7-one is a Sesquiterpenoids product that can be isolated from the roots of Euphorbia fischeriana. .
    4-Hydroxy-11,12,13-trinor-5-eudesmen-7-one
  • HY-N13201
    12-Deoxyphorbol 13-palmitate

    		Apoptosis CDK Cancer
    12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2 .
    12-Deoxyphorbol 13-palmitate
  • HY-N11736
    12-O-Tiglyl-phorbol 13-dodecanoate

    		Collagen Metabolic Disease
    12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis .
    12-O-Tiglyl-phorbol 13-dodecanoate

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