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Results for "

1,4-dihydropyrano[2,3-c]pyrazole

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Aurora Kinase (2) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (20) Calcium Channel (1) COX (2) Drug Derivative (1) Drug Intermediate (14) Environmental Pollutants (1) Estrogen Receptor/ERR (3) Glycosyltransferase (1) Herbicide (1) iGluR (2) Isotope-Labeled Compounds (8) Kallikrein (1) Mitosis (1) MOFs (35) Parasite (3) PDK-1 (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) PROTAC Linkers (1) Reference Standards (11) STING (1) TGF-β Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (3) Endocrinology (1) Infection (5) Inflammation/Immunology (6) Metabolic Disease (4)

By Targets:

Apoptosis (1)

Aurora Kinase (2)

Autophagy (1)

Bacterial (1)

Biochemical Assay Reagents (20)

Calcium Channel (1)

COX (2)

Drug Derivative (1)

Drug Intermediate (14)

Environmental Pollutants (1)

Estrogen Receptor/ERR (3)

Glycosyltransferase (1)

Herbicide (1)

iGluR (2)

Isotope-Labeled Compounds (8)

Kallikrein (1)

Mitosis (1)

MOFs (35)

Parasite (3)

PDK-1 (1)

Phosphodiesterase (PDE) (1)

Potassium Channel (1)

PROTAC Linkers (1)

Reference Standards (11)

STING (1)

TGF-β Receptor (1)

TRP Channel (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (5)

Inflammation/Immunology (6)

Metabolic Disease (4)

100

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-100689

*Propyl pyrazole* triol** Maximum Cited Publications 18 Publications Verification PPT	Estrogen Receptor/ERR	Cancer
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .

HY-10179

Danusertib 5+ Cited Publications PHA-739358	Aurora Kinase Autophagy	Cancer
Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC₅₀ of 13, 79, and 61 nM for Aurora A, B, and C, respectively.

HY-76228

1H-pyrazole pyrazole	Parasite iGluR	Infection
1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-W017032

*1H-Pyrazole-1-carboximidamide hydrochloride*	Biochemical Assay Reagents	Others
1H-Pyrazole-1-carboximidamide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W002736

*N,N'-Di-Boc-1H-pyrazole-1-carboximidamide*	Biochemical Assay Reagents	Others
N,N'-Di-Boc-1H-pyrazole-1-carboximidamide (Compound 1) is a guanylating agent. N,N'-Di-Boc-1H-pyrazole-1-carboximidamide reacts with amines and amino acids .

HY-I0308

*1-Methyl-1H-pyrazole-4-boronic acid pinacol ester*	Biochemical Assay Reagents Drug Intermediate	Others
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester is an organic synthetic intermediate, which can be used to synthesize other active compounds .

HY-19408

Pyr10 3 Publications Verification	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca ²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca ²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .

HY-W001242

*1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester*	Biochemical Assay Reagents Drug Intermediate	Others
1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester is a pharmaceutical intermediate used in the synthesis of naphthyl FXIa/PKa inhibitors .

HY-I0314

*1H-Pyrazole-4-boronic acid pinacol ester*	Drug Intermediate	Others
1H-Pyrazole-4-boronic acid pinacol ester is a drug intermediate that can be used for the synthesis of Mps1 kinase inhibitors .

HY-131062

yGsy2p-IN-1 2 Publications Verification	Glycosyltransferase	Metabolic Disease
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC₅₀ of 2.75 μM and a K_i of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) .

HY-17475

Nifenazone	Biochemical Assay Reagents	Inflammation/Immunology
Nifenazone is a pyrazole agent which can be used in the in the treatment of a variety of rheumatic disorders.

HY-69052

*1-Methyl-1H-pyrazole-4-carboxaldehyde*	Drug Intermediate	Others
1-Methyl-1H-pyrazole-4-carboxaldehyde is a pyrazole aldehyde intermediate that can be used for the synthesis of 1-methyl-1H-pyrazole-4-carboxylic acid .

HY-W004212

4-(Trifluoromethyl)-1H-pyrazole	Biochemical Assay Reagents	Others
4-(Trifluoromethyl)-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W003233

*1-Boc-pyrazole-4-boronic acid pinacol ester*	Biochemical Assay Reagents	Others
1-Boc-pyrazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-41514

*3-Iodo-1-tetrahydropyran-2-yl-pyrazole-4-carbaldehyde* 1 Publications Verification	Drug Intermediate	Others
3-Iodo-1-tetrahydropyran-2-yl-pyrazole-4-carbaldehyde is a drug intermediate for synthesis of various active compounds.

HY-W002351

*Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate*	Biochemical Assay Reagents	Others
Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0273

Propyphenazone 4-Isopropylantipyrine; Isopropylphenazone	COX	Inflammation/Immunology
Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity .

HY-12564

Phthalazinone pyrazole	Aurora Kinase Apoptosis Mitosis	Cancer
Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC₅₀ of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells .

HY-34027

*Ethyl 5-methyl-1H-pyrazole-3-carboxylate*	Biochemical Assay Reagents	Others
Ethyl 5-methyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Ethyl 5-methyl-1H-pyrazole-3-carboxylate can be used to synthesize 1-benzyl-5-methyl-1H-pyrazole-3-carboxylic acid .

HY-W047661

1-Cyclopropyl-4-ethynyl-1H-pyrazole	Drug Intermediate	Others
1-Cyclopropyl-4-ethynyl-1H-pyrazole is a drug intermediate for synthesis of various active compounds.

HY-B0784

*2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole* benzenesulfonate**	Drug Intermediate	Others
2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole benzenesulfonate is a drug intermediate for synthesis of various active compounds.

HY-75637

3-Amino-5-methylpyrazole	Drug Intermediate	Others
5-Methyl-1H-pyrazol-3-amine is a pyrazole heterocyclic compound and can be used as a key intermediate for the synthesis of pyrazolylamide derivatives.

HY-133726

Bixafen	Bacterial	Infection
Bixafen, a member of the pyrazole class of fungicides, serves as a broad-spectrum agent for controlling pathogens in cereal crops by functioning as a succinate dehydrogenase inhibitor.

HY-21057

3-(Pyridin-2-yl)pyrazole	MOFs	Others
3-(Pyridin-2-yl)pyrazole is a metal-organic framework (MOF).

HY-34603

*1-Methyl-1H-pyrazole-3-carboxylic acid*	Biochemical Assay Reagents Drug Intermediate	Metabolic Disease
1-Methyl-1H-pyrazole-3-carboxylic acid is an intermediate. 1-Methyl-1H-pyrazole-3-carboxylic acid can be used in the synthesis of Compound 91 (SCD1 and SCD5 inhibitor). 1-Methyl-1H-pyrazole-3-carboxylic acid can used in the research of metabolic disorders .

HY-118810

BIO-013077-01	TGF-β Receptor	Cancer
BIO-013077-01 is a pyrazole TGF-β inhibitor .

HY-W004978

*1,5-Dimethyl-1H-pyrazole-3-carboxylic acid*	Biochemical Assay Reagents	Others
1,5-Dimethyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W017713

4-[4-(1H-Pyrazol-4-yl)phenyl]-1H-pyrazole 1,4-Di(1H-pyrazol-4-yl)benzene	MOFs	Others
4-[4-(1H-Pyrazol-4-yl)phenyl]-1H-pyrazole (1,4-Di(1H-pyrazol-4-yl)benzene) is a metal-organic framework (MOF).

HY-W002328

Pyrazole-3-carboxylic acid	Biochemical Assay Reagents	Others
Pyrazole-3-carboxylic acid is an alternative anchoring group to carboxylic acid in phthalocyanine dyes. Pyrazole-3-carboxylic acid shows flexible coordination modes when coordinates with metal ions. Pyrazole-3-carboxylic acid can chelate to metal ions and form very stable complexes through its N and O atoms. Pyrazole-3-carboxylic acid can be used to synthesize derivatives that possess antibacterial, anti-inflammatory, ulcerogenic liability and antiproliferative activities .

HY-W067376

*1H-pyrazole-3,5-dicarboxylic acid hydrate* pyrazole-3,5-dicarboxylic acid monohydrate	MOFs	Others
1H-pyrazole-3,5-dicarboxylic acid hydrate (Pyrazole-3,5-dicarboxylic acid monohydrate) is a metal-organic framework (MOF).

HY-127133

Methylpiperidino pyrazole MPP	Estrogen Receptor/ERR	Endocrinology
Methylpiperidino pyrazole (MPP) is a potent and selective ER (estrogen receptor) modulator. Methylpiperidino pyrazole induces significant apoptosis in the endometrial cancer and oLE cell lines. Methylpiperidino pyrazole reverses the the positive effects of beta-estradiol. Methylpiperidino pyrazole has mixed agonist/antagonist action on murine uterine ERalpha in vivo .

HY-W779244

*1H-Pyrazole-3,4,5-d3*	Isotope-Labeled Compounds Biochemical Assay Reagents Drug Intermediate	Infection
1H-Pyrazole-3,4,5-d₃ is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-W007997

*Ethyl 3-amino-1H-pyrazole-4-carboxylate* 3-Amino-4-ethoxycarbonylpyrazole	Biochemical Assay Reagents	Others
Ethyl 3-amino-1H-pyrazole-4-carboxylate (3-Amino-4-ethoxycarbonylpyrazole) is a pyrazole organic compound containing an amino group and an ethoxycarbonyl group. Ethyl 3-amino-1H-pyrazole-4-carboxylate can be used as a ligand in the synthesis of metal coordination compounds .

HY-21376S

*tert-Butyl 4-amino-1H-pyrazole-1-carboxylate-d2*	Isotope-Labeled Compounds	Others
tert-Butyl 4-amino-1H-pyrazole-1-carboxylate-d₂ is the deuterium labeled tert-Butyl 4-amino-1H-pyrazole-1-carboxylate.

HY-22365

*1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid*	Biochemical Assay Reagents	Others
1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-145568

Feniralstat KVD-824	Kallikrein	Cardiovascular Disease Metabolic Disease
Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM) .

HY-W112721

1H,1'H-4,4'-Bipyrazole 4-(1H-Pyrazol-4-yl)-1H-pyrazole	MOFs	Others
1H,1'H-4,4'-Bipyrazole (4-(1H-Pyrazol-4-yl)-1H-pyrazole) is a metal-organic framework (MOF).

HY-W075124

*1,3-Di(1H-pyrazol-4-yl)benzene* 4,4'-(1,3-Phenylene)bis-1H-pyrazole	MOFs	Others
1,3-Di(1H-pyrazol-4-yl)benzene (4,4'-(1,3-Phenylene)bis-1H-pyrazole) is a metal-organic framework (MOF).

HY-107448

*1H-Pyrazole-1-carboxylic acid, 3-amino-5-cyclobutyl-, 1,1-dimethylethyl ester* Protac cdk9-binding moiety 1	Drug Intermediate	Others
1H-Pyrazole-1-carboxylic acid, 3-amino-5-cyclobutyl-, 1,1-dimethylethyl ester (Protac cdk9-binding moiety 1) is a drug intermediate for synthesis of various active compounds.

HY-174170

*(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide*	STING	Cancer
(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing a key amide benzimidazole (ABZI) component and shows reproducible inhibition of 3H-cGAMP binding to STING with an apparent inhibition constant IC₅₀ of 14 μM. (S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide can be used for tumor research .

HY-B1850

Halosulfuron-methyl Inpool; MON 12000; Manage	Environmental Pollutants Herbicide	Others
Halosulfuron-methyl is a pyrazole sulfonylurea herbicide .

HY-76228R

*1H-pyrazole* (Standard)** pyrazole (Standard)	Reference Standards Parasite iGluR	Infection Inflammation/Immunology
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-172297

Pyrazole N-Desmethyl sildenafil	Phosphodiesterase (PDE) Parasite	Infection Cardiovascular Disease Cancer
Pyrazole N-Desmethyl sildenafil (Compound 10) is an analog of Sildenafil (HY-15025). Pyrazole N-Desmethyl sildenafil shows 16% inhibition on Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) with 100 µM .

HY-100689R

*Propyl pyrazole* triol (Standard)** PPT (Standard)	Reference Standards Estrogen Receptor/ERR	Cancer
Propyl pyrazole triol (Standard) is the analytical standard of Propyl pyrazole triol. This product is intended for research and analytical applications. Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .

HY-W017032R

*1H-Pyrazole-1-carboximidamide hydrochloride (Standard)*	Biochemical Assay Reagents Reference Standards	Others
1H-Pyrazole-1-carboximidamide (hydrochloride) (Standard) is the analytical standard of 1H-Pyrazole-1-carboximidamide (hydrochloride). This product is intended for research and analytical applications.

HY-Z1094

1-Ethyl-1H-pyrazole	Drug Intermediate	Others
1-Ethyl-1H-pyrazole is a drug impurity.

HY-139994

XN methyl pyrazole XP	Others	Metabolic Disease Cancer
XN methyl pyrazole improves diet-induced obesity and induces energy expenditure in high-fat diet-fed mice .

HY-Z1093

1-Propyl-1H-pyrazole 1-Propylpyrazole	Drug Intermediate	Others
1-Propyl-1H-pyrazole is a drug impurity.

HY-168227

*trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc*	PROTAC Linkers	Cancer
trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc is a PROTAC linker. trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc can be used in the synthesis of PROTAC SMARCA2/4-degrader-35 (HY-168225) .

HY-W077074S

*1-Ethyl-1H-pyrazole-5-carboxylic acid-d5*	Isotope-Labeled Compounds	Others
1-Ethyl-1H-pyrazole-5-carboxylic acid-d₅ is the deuterium labeled 1-Ethyl-1H-pyrazole-5-carboxylic acid (HY-W077074).

Cat. No.	상품명	Category	Target	Chemical Structure

HY-76228

1H-pyrazole pyrazole	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Parasite iGluR
1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-76228R

*1H-pyrazole* (Standard)** pyrazole (Standard)	Alkaloids Structural Classification Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Parasite iGluR
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

Cat. No.	상품명	Chemical Structure

HY-W779244

1H-Pyrazole-3,4,5-d3

1H-Pyrazole-3,4,5-d₃ is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-21376S

*tert-Butyl 4-amino-1H-pyrazole-1-carboxylate-d2*
tert-Butyl 4-amino-1H-pyrazole-1-carboxylate-d₂ is the deuterium labeled tert-Butyl 4-amino-1H-pyrazole-1-carboxylate.

HY-W077074S

*1-Ethyl-1H-pyrazole-5-carboxylic acid-d5*
1-Ethyl-1H-pyrazole-5-carboxylic acid-d₅ is the deuterium labeled 1-Ethyl-1H-pyrazole-5-carboxylic acid (HY-W077074).

HY-W249514

*1-Methyl-1H-pyrazole-4-boronic acid pinacol ester-d3*
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester-d₃ is the deuterium labeled 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester (HY-I0308). 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W726534

*5-Methyl-1-(methyl-d3)-1H-pyrazole-4-sulfonamide*
5-Methyl-1-(methyl-d₃)-1H-pyrazole-4-sulfonamide is the deuterium labeled 5-Methyl-1-(methyl)-1H-pyrazole-4-sulfonamide.

HY-W724450

*3-Methyl-1-(methyl-d3)-1H-pyrazole-4-sulfonamide*
3-Methyl-1-(methyl-d₃)-1H-pyrazole-4-sulfonamide is the deuterium labeled 1,3-Dimethyl-1H-pyrazole-4-sulfonamide (HY-W060881).

HY-132518S

Pyrazole N-Demethyl Sildenafil-d3
Pyrazole N-Demethyl Sildenafil-d₃ is the deuterium labeled Pyrazole N-Demethyl Sildenafil .

HY-W005926S

*1,5-Dimethyl-1H-pyrazole-4-carboxylic acid-d6*
1,5-Dimethyl-1H-pyrazole-4-carboxylic acid-d₆ (1,5-Dimethylpyrazole-4-carboxylic acid-d₆) is the deuterium labeled 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid.

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