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3C-like proteinase

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標的別:	5-HT Receptor (2) Influenza Virus (2) Reference Standards (1) SARS-CoV (1)
研究分野別:	Infection (3) Inflammation/Immunology (2)

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組換えタンパク質

Targets Recommended: Procollagen C Proteinase

製品番号	製品名	Target	研究分野	構造式

HY-100943

Cinanserin hydrochloride 1 Publications Verification SQ 10643	5-HT Receptor Influenza Virus	Infection Inflammation/Immunology
Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT₂ receptor antagonist with a K_i of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT₂ than for the 5-HT₁ receptor (K_i of 3500 nM). Cinanserin is also an inhibitor of **3C-like proteinase** of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro .

HY-177910

Anticoronavirus agent-1	SARS-CoV	Infection
Anticoronavirus agent-1 (Compound IV-2) is a 1,4-naphthone compound and is a 3CL hydrolase inhibitor (3C-like *proteinase*) of the 19-nCoV novel coronavirus. Anticoronavirus agent-1 has low cytotoxity on HSF cells. Anticoronavirus agent-1 can be used for the study of the novel coronavirus .

HY-100943R

Cinanserin hydrochloride (Standard) SQ 10643 (Standard)	5-HT Receptor Reference Standards Influenza Virus	Infection Inflammation/Immunology
Cinanserin (hydrochloride) (Standard) is the analytical standard of Cinanserin (hydrochloride) (HY-100943). This product is intended for research and analytical applications. Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro .

Species:	Virus (7)
Tag:	His (5) Tag Free (2) Avi (2)
Source:	Sf9 insect cells (2) E. coli (5)

製品番号	Compare	製品名	Species	Source	Image

HY-P7429

	*SARS-CoV-2 3C-like* Proteinase (His)** M proteinase; 3CL proteinase; 2019-nCoV 3C-like proteinase	Virus	E. coli
	SARS-CoV-2 3C-like Proteinase (His), His, expressed in E.coli, mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription with a His tag at the N-terminus.

HY-P7429A

	*SARS-CoV-2 3C-like* Proteinase (N-His)** M proteinase; 3CL proteinase; 2019-nCoV 3C-like proteinase	Virus	E. coli
	SARS-CoV-2 3C-like Proteinase (His), His, expressed in E.coli, mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription with a His tag at the N-terminus.

HY-P76590

	*SARS-CoV-2 3CLpro/3C-like* protease Protein (His-Avi)** 3CL Protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main Protease; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by E. coli, with N-His, N-Avi labeled tag.

HY-P78275

	SARS-CoV-2 3CLpro/3C-like protease Protein 3C-like protease; 3CL Protease; 3CL-Mpro; 3CL Pro; COVID-19; M proteinase; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease is a viral cysteine protease that plays a crucial role in the co-translational proteolytic processing of coronavirus polyproteins. Since no homologous proteins with similar cleavage sites exist in the human body, SARS-CoV-2 3CLpro/3C-like protease is a high-quality target for the development of drugs related to COVID-19. SARS-CoV-2 3CLpro/3C-like protease protein is a recombinant, untagged SARS-CoV-2 3CLpro/3C-like protease protein expressed by E.coli.

HY-P76589

	*SARS-CoV-2 3CLpro/3C-like* protease Protein (sf9, His)** 3CL Protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main Protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells, with N-His labeled tag.

HY-P76591

	*SARS-CoV-2 3CLpro/3C-like* protease Protein (sf9, His-Avi)** 3CL Protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main Protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells, with N-His, N-Avi labeled tag.

HY-P78275A

	*SARS-CoV-2 3CLpro/3C-like* protease Protein (Tag Free)** 3C-like protease; 3CL Protease; 3CL-Mpro; 3CL Pro; COVID-19; M proteinase; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a viral cysteine protease that plays a crucial role in the co-translational proteolytic processing of coronavirus polyproteins. Since no homologous proteins with similar cleavage sites exist in the human body, SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a high-quality target for the development of drugs related to COVID-19. SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a recombinant, SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) expressed by E.coli.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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