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ATG5-ATG16L1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-183829
    ATG5-TECAIR-IN-2

    		Autophagy Others
    ATG5-TECAIR-IN-2 is a ATG5 inhibitor with autophagy inhibitory activity. ATG5-TECAIR-IN-2 selectively inhibits the ATG5-TECAIR interaction (IC50=31.24 μM) and shows no activity against the ATG5-ATG16L1 interaction .
    ATG5-TECAIR-IN-2
  • HY-183736
    Autophagy-IN-12

    		Others
    Autophagy-IN-12 (Compound 17e) is a autophagy inhibitor. Autophagy-IN-12 exhibits an IC50 value of >33 μM against the protein-protein interactions of ATG5-ATG16L1 and ATG5-TECAIR .
    Autophagy-IN-12
  • HY-183731
    ATG5 PPI-IN-1

    		Autophagy Others
    ATG5 PPI-IN-1 (Compound 17b) is a ATG5 protein-protein interaction inhibitor, with an IC50 of 27.43 μM for the ATG5-ATG16L1 interaction and an IC50 of 14.88 μM for the ATG5-TECAIR interaction .
    ATG5 PPI-IN-1
  • HY-183827
    ATG5 PPI-IN-5

    		Autophagy Others
    ATG5 PPI-IN-5 is a Autophagy-Related ATG5 protein-protein interaction inhibitor and autophagy inhibitor. The IC50 values of ATG5 PPI-IN-5 for the interactions of ATG5-ATG16L1 and ATG5-TECAIR are >33 μM .
    ATG5 PPI-IN-5
  • HY-183835
    Autophagy-IN-10

    		Autophagy Others
    Autophagy-IN-10 (Compound 12a) is an Autophagy inhibitor and an inhibitor of ATG5 interaction with other proteins, with an IC50 value of 2.29 μM against ATG5-ATG16L1 and an IC50 value of 3.68 μM against ATG5-TECAIR .
    Autophagy-IN-10
  • HY-183867
    ATG5 PPI-IN-6

    		Autophagy Others
    ATG5 PPI-IN-6 (Compound 17a) is an inhibitor of ATG5 interactions with other proteins, with an IC50 value of 26.92 μM against ATG5-ATG16L1 and 16.34 μM against ATG5-TECAIR. ATG5 PPI-IN-6 inhibits Autophagy in cells .
    ATG5 PPI-IN-6
  • HY-183730
    4E1RCat 17d

    		Autophagy Drug Derivative Others
    4E1RCat 17d (Compound 17d) is a derivative of the ATG5 inhibitor lead compound T1742. 4E1RCat 17d shows no activity against the interactions of ATG5-ATG16L1 and ATG5-TECAIR. 4E1RCat 17d induces Autophagy inhibition .
    4E1RCat 17d
  • HY-183826
    ATG5 PPI-IN-4

    		Autophagy Infection Cancer
    ATG5 PPI-IN-4 is an autophagy inhibitor targeting ATG5, with an IC50 of 12.78 μM against ATG5-ATG16L1 and an IC50 of 12.00 μM against ATG5-TECAIR. ATG5 PPI-IN-4 blocks the protein interactions between ATG5 and ATG16L1, as well as between ATG5 and TECAIR, disrupts the assembly of the ATG12-ATG5-ATG16L1 ternary complex, inhibits the lipidation modification of LC3/ATG8, and ultimately downregulates cellular autophagy levels. ATG5 PPI-IN-4 can be used in autophagy-related research, such as studies on infection and cancer .
    ATG5 PPI-IN-4
  • HY-183833
    Autophagy-IN-9

    		Autophagy Infection
    Autophagy-IN-9 is a ATG5 inhibitor with an IC50 of 21.29 μM against ATG5-TECAIR. Autophagy-IN-9 blocks the binding of ATG5 to the hot-spot amino acid residues of TECAIR protein, disrupts the assembly of ATG5-related ternary complexes, inhibits autophagosome formation, and thereby downregulates cellular autophagy levels. Autophagy-IN-9 can be used in autophagy-related research, such as studies on infection .
    Autophagy-IN-9

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