150 Results for "

Antimycobacterials

" in MedChemExpress (MCE) Product Catalog:
Products (150)

150 Results for "Antimycobacterials" in MCE Product Catalog:

13
13 Publications Verification
Cat. No.: HY-B1046
CAS No.: 2030-63-9
Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC50 = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-17025
CAS No.: 72559-06-9
Synonyms: Ansamycin; LM-427
Research Areas:  

Infection

Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-W012875
CAS No.: 504-88-1
Synonyms: β-Nitropropionic acid; Bovinocidin
3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible and orally active inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM. 3-Nitropropanoic acid can induce cell apoptosis .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-B0535A
CAS No.: 1070-11-7
Synonyms: Emb dihydrochloride
Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol dihydrochloride can be used to establish animal models of hyperuricemia and optic neuropathy.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-B0688
CAS No.: 80-08-0
Synonyms: 4,4′-Diaminodiphenyl sulfone; DDS
Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-B0535
CAS No.: 74-55-5
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Ethambutol is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol can be used to establish animal models of hyperuricemia and optic neuropathy.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-100725
CAS No.: 146204-42-4
Purity:  99.51%
Target:  

Bacterial

Research Areas:  

Infection

BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-N0941
CAS No.: 20931-37-7
Synonyms: β-Mangostin
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-N7030
CAS No.: 855-97-0
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N1976
CAS No.: 225110-25-8
Synonyms: (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol
(+)-(3R,8S)-Falcarindiol ((3R,8S)-Falcarindiol; 3 (R),8 (S),9 (Z)-Falcarindiol) is an orally active polyacetylene anti-mycobacterial agent. (+)-(3R,8S)-Falcarindiol exhibits antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and mycobacteria. Co-administration of (+)-(3R,8S)-Falcarindiol with (3R)-falcarinol alters the composition of gut microbiota, reduces colonic tumor lesions and slows down polyp growth. (+)-(3R,8S)-Falcarindiol can be used in research related to tuberculosis and colorectal cancer .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N3845
CAS No.: 2061-64-5
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-109588
CAS No.: 1473450-62-2
Purity:  98.98%
Target:  

Bacterial

Research Areas:  

Infection

NITD-349 is an MmpL3 inhibitor that shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.
loading...
    loading...
Cat. No.: HY-P2970
CAS No.: 37189-34-7
Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning .
loading...
    loading...
Cat. No.: HY-17025S
CAS No.: 2747918-39-2
Synonyms: Ansamycin-d7; LM-427-d7
Rifabutin-d7 is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.
loading...
    loading...
Cat. No.: HY-N1205
CAS No.: 6750-60-3
Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system .
loading...
    loading...
Cat. No.: HY-N2060
CAS No.: 15266-38-3
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca 2+ influx through voltage-dependent calcium channels. Antimycobacterial activity .
loading...
    loading...
Cat. No.: HY-141715
CAS No.: 2365504-95-4
Purity:  99.65%
Target:  

Antibiotic

Research Areas:  

Infection

BRD-8000.3, as a specific EfpA inhibitor, is a narrow-spectrum, bactericidal antimycobacterial agent with good wild-type activity. BRD-8000.3 can be used for the research of tuberculosis .
loading...
    loading...
Cat. No.: HY-129605
CAS No.: 6805-34-1
Purity:  ≥99.0%
Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action .
loading...
    loading...
Cat. No.: HY-W001663
CAS No.: 876-02-8
4'-Hydroxy-3'-methylacetophenone is a phenolic volatile compound. 4'-Hydroxy-3'-methylacetophenone can be isolated from Hawaiian green coffee beans (Coffea Arabica L.). 4'-Hydroxy-3'-methylacetophenone is believed to possess potent antioxidant activity similar to that of other phenolic volatile compounds, Thymol (HY-N6810) and Eugenol (HY-N0337). 4'-Hydroxy-3'-methylacetophenone also can be used to synthesize heterocyclic compounds which have antimycobacterial activity .
loading...
    loading...
Cat. No.: HY-109587
CAS No.: 1493762-74-5
Purity:  98.06%
Target:  

Bacterial

Research Areas:  

Infection

BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC50 of 0.12 μM against M. tuberculosis H37Rv.
loading...
    loading...