1 Result for "

BTT369

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "BTT369" in MCE Product Catalog:

Cat. No.: HY-115596
CAS No.: 2413939-96-3
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

BTT-369 is a CaVα1·CaVβ3 protein-protein complex antagonist with a Ki of 2.0 μM. BTT-369 inhibits CaV2.2 currents, with an apparent IC50 value of 31 μM. BTT-369 disrupts the interaction between CaVα1 and CaVβ3 subunits. BTT-369 reduces the current density of CaV2.2, and shifts the voltage dependence of steady-state inactivation and activation of CaV2.2 to more positive potentials. BTT-369 alleviates mechanical hyperalgesia in a rat model of tibial nerve injury. BTT-369 can be used for the study of neuropathic pain .
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