Search Result

Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

CA enzyme

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (7) Calmodulin (1) CaMK (1) Angiotensin Receptor (2) Arp2/3 Complex (1) Bacterial (2) Biochemical Assay Reagents (2) Calcineurin (1) Carbonic Anhydrase (3) Caspase (1) Chloride Channel (1) Cholinesterase (ChE) (2) Cytochrome P450 (4) Drug Derivative (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) mTOR (1) NF-κB (1) NO Synthase (1) NOD-like Receptor (NLR) (1) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (1) PD-1/PD-L1 (2) Phosphodiesterase (PDE) (2) Phospholipase (1) PKA (1) PKC (3) PKG (1) Potassium Channel (1) Proteasome (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Sodium Channel (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (5) Endocrinology (3) Infection (3) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (6)

By Targets:

Calcium Channel (7)

Calmodulin (1)

CaMK (1)

Angiotensin Receptor (2)

Arp2/3 Complex (1)

Bacterial (2)

Biochemical Assay Reagents (2)

Calcineurin (1)

Carbonic Anhydrase (3)

Caspase (1)

Chloride Channel (1)

Cholinesterase (ChE) (2)

Cytochrome P450 (4)

Drug Derivative (1)

Endogenous Metabolite (1)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (1)

mTOR (1)

NF-κB (1)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

Nuclear Factor of activated T Cells (NFAT) (1)

p38 MAPK (1)

PD-1/PD-L1 (2)

Phosphodiesterase (PDE) (2)

Phospholipase (1)

PKA (1)

PKC (3)

PKG (1)

Potassium Channel (1)

Proteasome (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

Sodium Channel (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (5)

Endocrinology (3)

Infection (3)

Inflammation/Immunology (5)

Metabolic Disease (6)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Calcium Channel CRAC Channel Peroxidase Enzyme Na+/Ca2+ Exchanger E1/E2/E3 Enzyme Carnosine-cleaving Enzyme Proteolytic Enzyme CaSR Endothelin-Converting Enzyme (ECE) Calmodulin Angiotensin-converting Enzyme (ACE) IRE1 NEDD8-activating Enzyme CaMK IDE TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W019981B

Magnesium chloride hexahydrate, for molecular biology MgCl2 hexahydrate, for molecular biology	Calcium Channel Biochemical Assay Reagents	Metabolic Disease
Magnesium chloride hexahydrate (MgCl₂ hexahydrate), for molecular biology is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate increases the activity of Ca ²⁺ ATPase .

HY-W019981C

Magnesium chloride hexahydrate, for cell culture MgCl2 hexahydrate, for cell culture	Calcium Channel Biochemical Assay Reagents	Metabolic Disease
Magnesium chloride hexahydrate (MgCl₂ hexahydrate), for cell culture is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate, for cell culture can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate, for cell culture increases the activity of Ca ²⁺ ATPase .

HY-50722

NNC 55-0396 5 Publications Verification NNC 55-0396 dihydrochloride	Calcium Channel Cytochrome P450	Cardiovascular Disease Neurological Disease Cancer
NNC 55-0396 (NNC 55-0396 dihydrochloride) is a blood-brain-barrier-permeable T-type Ca ²⁺ channel inhibitor and pan-P450 inhibitor. NNC 55-0396 selectively inhibits T-type Ca ²⁺ channels, suppresses HIF-1α expression and stability and inhibits Kv currents. NNC 55-0396 reduces brain infarct and attenuates neurological dysfunction. NNC 55-0396 inhibits the activity of multiple P450 enzymes. NNC 55-0396 (free base) can be used for the research of brain injury, hypertension, and glioblastoma .

HY-101093

CA-170 2 Publications Verification	PD-1/PD-L1	Inflammation/Immunology Cancer
CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .

HY-N2157

Pteryxin 1 Publications Verification (+)-Pteryxin	Cholinesterase (ChE) NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS) Nuclear Factor of activated T Cells (NFAT) p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology
Pteryxin ((+)-Pteryxin) is an orally active multi-target inhibitor that targets NF-κB, MAPK, NLRP3 inflammasome, and Nrf2/ARE pathways. Pteryxin is also a BChE inhibitor (IC₅₀=12.96 μg/mL) with a low inhibitory efficiency on AChE. Pteryxin inhibits the Ca ²⁺-calcineurin-NFATc1 pathway by blocking NF-κB/MAPK signaling, inhibiting NLRP3 inflammasome activation, and reducing ROS generation, and activates Nrf2-mediated antioxidant enzyme expression. Pteryxin has anti-inflammatory, antioxidant, and osteoclastogenesis inhibitory activities. Pteryxin can be used in the study of inflammatory diseases, osteoporosis, diabetes, and Alzheimer's disease .

HY-142117

Adenophostin A	Calcium Channel Chloride Channel	Others
Adenophostin A is an IP₃ receptor (inositol 1,4,5-trisphosphate receptors) modulator and Ca ²⁺ releaser, with an IC₅₀ of 1.3 nM, an EC₅₀ of 1.4 nM, and a K_i of 0.18 nM in rats, and an IC₅₀ of 0.95 nM in humans. Adenophostin A activates IP₃ receptors, stimulates Ca ²⁺ release from intracellular stores and microsomes, inhibits the binding of [ ³H]IP₃ to plasma membrane receptors, and activates chloride channels. Adenophostin A resists phosphorylation and dephosphorylation by IP₃ metabolic enzymes to maintain its activity, and increases cytoplasmic [Ca ²⁺] levels via calcium mobilization from the endoplasmic reticulum of vascular smooth muscle cells. Adenophostin A is applicable to research related to hemorrhagic shock .

HY-131900

Protein kinase inhibitor H-7	PKC PKA PKG Arp2/3 Complex	Others
Protein kinase inhibitor H-7 is a selective inhibitor of PKC and cyclic nucleotide-dependent protein kinases, with a K_i value of 6.0 μM for rabbit protein kinase C, a K_i value of 3.0 μM for rabbit cAMP-dependent protein kinase, and a K_i value of 5.8 μM for porcine cGMP-dependent protein kinase. Protein kinase inhibitor H-7 has no effect on Ca ²⁺-calmodulin-dependent enzymes. Protein kinase inhibitor H-7 regulates the Actin cytoskeleton, inhibits contractility, disrupts stress fibers, induces protrusive activity, stabilizes intercellular junctions, and triggers rapid and reversible cytoskeletal reorganization. Protein kinase inhibitor H-7 serves as a research tool for elucidating the functions of protein kinase C-mediated signaling systems .

HY-E70234A

Sortase A, S. aureus (non-Ca²⁺-dependent)	Bacterial	Infection Inflammation/Immunology
Sortase A, S. aureus (non-Ca ²⁺-dependent), a transpeptidase enzyme is present in many Gram-positive bacteria and helps in the recruitment of the cell surface proteins. Sortase A, S. aureus (non-Ca ²⁺-dependent) plays an important part in ligation of various molecules on the cell surfaces .

HY-76779

4-(Chloromethyl)-7-hydroxycoumarin	Drug Derivative	Cancer
4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .

HY-145384

ROC-0929	Phospholipase	Inflammation/Immunology
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A₂ (sPLA₂s) with an IC₅₀ of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca ²⁺-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .

HY-B0124S

Zonisamide-d4	Isotope-Labeled Compounds Carbonic Anhydrase Calcium Channel Sodium Channel	Neurological Disease
Zonisamide-d₄ is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with K_is of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-19230

DY-9760e	Calmodulin NO Synthase CaMK Calcineurin Proteasome Caspase	Cardiovascular Disease
DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (K_i: 0.9, 1.4, and 2.0 μM, respectively). DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of calpain and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases .

HY-156013

CA inhibitor 2	Carbonic Anhydrase	Endocrinology Cancer
CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC₅₀: 0.033 μM) .

HY-139041

Palmitoylcholine chloride	Phosphodiesterase (PDE)	Others
Palmitoylcholine chloride reduces membrane stress and reduces enzyme activity by Ca(2+)-dependent phosphatidylinositol phosphodiesterase (EC 3.1.4.10) hydrolysis of phosphatidylinositol monolayers .

HY-N10754

Aschantin	mTOR Cytochrome P450	Infection Cardiovascular Disease Cancer
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca ²⁺-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-174835

hCA-I/hCA-II-IN-1	Carbonic Anhydrase	Cardiovascular Disease
hCA-I/hCA-II-IN-1 (Compound P4) is a potent dual human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) inhibitor with K_i values of 0.22 μM and 0.33 μM, respectively. hCA-I/hCA-II-IN-1 can be used in research on diseases related to CA enzymes such as glaucoma, hypertension, and ulcers .

HY-19397

BMS-223131	Potassium Channel Cytochrome P450	Neurological Disease
BMS-223131 (Compound 1) is a potent maxi-K potassium channel opener. BMS-223131 has a strong inhibitory effect on the CYP2C9 enzyme (IC₅₀ = 1.7 μM) and also shows varying degrees of inhibition on other common CYP enzymes such as CYP1A2, CYP2C19, CYP2D6, and CYP3A4. BMS-223131 can enhance the outward current mediated by maxi-K, by promoting K ⁺ efflux to hyperpolarize the cell membrane and reducing Ca ²⁺ influx. BMS-223131 can be used for the research of neurological disease, such as stroke .

HY-101093R

CA-170 (Standard)	PD-1/PD-L1 Reference Standards	Inflammation/Immunology Cancer
CA-170 (Standard) is the analytical standard of CA-170 (HY-101093). This product is intended for research and analytical applications. CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .

HY-113658

ts-SA	Endogenous Metabolite	Others
ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn(II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor .

HY-E70949

Protein Kinase C,Rat	PKC	Metabolic Disease
Protein Kinase C,Rat (EC 2.7.1.37) is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. Protein Kinase C in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca ²⁺).

HY-114554

KS 619-1	Phosphodiesterase (PDE) PKC Bacterial	Infection
KS 619-1 is a Ca ²⁺/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus .

HY-50722B

NNC 55-0396 free base	Calcium Channel Cytochrome P450	Cardiovascular Disease Neurological Disease Cancer
NNC 55-0396 free base is a blood-brain-barrier-permeable T-type Ca ²⁺ channel inhibitor and pan-P450 inhibitor. NNC 55-0396 free base selectively inhibits T-type Ca²⁺ channels, suppresses HIF-1α expression and stability and inhibits Kv currents. NNC 55-0396 free base reduces brain infarct and attenuates neurological dysfunction. NNC 55-0396 free base inhibits the activity of multiple P450 enzymes. NNC 55-0396 (free base) can be used for the research of brain injury, hypertension, and glioblastoma .

HY-180891

Multitarget AD-IN-4	Cholinesterase (ChE) Calcium Channel	Neurological Disease
Multitarget AD-IN-4 (compound IIIj) is a multitarget-directed ligand (MTDL), with the ability to simultaneously inhibit ChE enzymes (EeAChE IC₅₀ = 0.157 μM, eqBuChE IC₅₀ = 0.147 μM, hAChE IC₅₀ = 1.551 μM, hBuChE IC₅₀ = 2.152 μM), exhibit antioxidant activity, provide neuroprotection, and inhibit calcium channels (Ca ²⁺ channel blockade: IC₅₀ = 30.59 μM). Multitarget AD-IN-4 reverses Scopolamine (HY-N0296)-induced amnesia in a mouse model. Multitarget AD-IN-4 can be used for Alzheimer’s disease (AD) research .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library	1,679 compounds
Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important. MCE designs a unique collection of 1,679 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Ion Channel Compound Library

1,679 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,679 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type