142115-17-1
Chemical Structure
Isosalvianolic acid C
- CAS No.: 142115-17-1
- Formula:C26H20O10
- Molecular Weight:492.43
IUPAC Name: (R,E)-3-(3,4-dihydroxyphenyl)-2-((3-(4,7,8-trihydroxydibenzo[b,f]oxepin-1-yl)acryloyl)oxy)propanoic acid
InChIKey: AVGRZVZQTALJJF-VURDRKPISA-N
SMILES: OC(C=C1C[C@H](C(O)=O)OC(/C=C/C2=C3C(OC4=CC(O)=C(O)C=C4C=C3)=C(C=C2)O)=O)=C(C=C1)O
Biological Activity: Isosalvianolic acid C is a naturally derived phenolic compound that acts as a signal modulator, antioxidant, and enzyme inhibitor. Isosalvianolic acid C induces the phosphorylation of PLC-γ, IP3R, PKC, and P38, triggering Ca2+ mobilization, degranulation, and chemokine release. Isosalvianolic acid C activates MRGPRX2 and its murine homolog MrgprB2, leading to pseudo-allergic reactions in vivo. Isosalvianolic acid C inhibits Cu2+-induced LDL peroxidation. Isosalvianolic acid C can be used in studies related to pseudo-allergy, diabetes, and atherosclerosis[1][2][3].
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Isosalvianolic acid C | Isosalvianolic acid C is a naturally derived phenolic compound that acts as a signal modulator, antioxidant, and enzyme inhibitor. Isosalvianolic acid C induces the phosphorylation of PLC-γ, IP3R, PKC, and P38, triggering Ca2+ mobilization, degranulation, and chemokine release. Isosalvianolic acid C activates MRGPRX2 and its murine homolog MrgprB2, leading to pseudo-allergic reactions in vivo. Isosalvianolic acid C inhibits Cu2+-induced LDL peroxidation. Isosalvianolic acid C can be used in studies related to pseudo-allergy, diabetes, and atherosclerosis. | |||||||||||||||||||||
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- [1]. Lin Y, et al. Isosalvianolic acid C-induced pseudo-allergic reactions via the mast cell specific receptor MRGPRX2. International immunopharmacology. 2019 Jun;71:22-31. [Content Brief]
- [2]. Ma HY, et al. Constituents with α-glucosidase and advanced glycation end-product formation inhibitory activities from Salvia miltiorrhiza Bge. Journal of natural medicines. 2011 Jan;65(1):37-42. [Content Brief]
- [3]. Lin YL, et al. Anti-lipid-peroxidative principles from Tournefortia sarmentosa. Journal of natural products. 2002 May;65(5):745-7. [Content Brief]
Keywords
