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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
CML
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "CML" in MCE Product Catalog:
13
13 Publications Verification
Target:
Research Areas:
PT2399 is a selective and orally active HIF-2α antagonist (IC50 < 5 nM) that binds the PAS-B domain and disrupts HIF-2α-ARNT heterodimerization. PT2399 inhibits HIF-2α-driven transcription, destabilizes HIF-2α, and suppresses HIF target genes without inhibiting HIF1α. PT2399 reduces tumor cell proliferation, vessel area, circulating tumor-derived VEGFA/VEGF, and lactate while increasing pyruvate. PT2399 can be used for research on clear cell renal cell carcinoma and chronic myeloid leukemia (CML).
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5
5 Cited Publications
KW-2478 is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 downregulates STAT3 expression. KW-2478 may be used in research on cancers such as CML and liver cancer .
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3 Cited Publications
GNF-5, the N-hydroxyethyl carboxamide analog of GNF-2, is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC50 value of 0.22 µM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer .
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Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic myeloid leukemia (CML) research . Vodobatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1
1 Cited Publications
Synonyms: 18:0 Lyso-PC; LPC(18:0)
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Target:
1
1 Cited Publications
Cat. No.: HY-W286743
CAS No.: 5746-04-3
Synonyms: CML; N6-(Carboxymethyl)-L-lysine; Nε-(1-Carboxymethyl)-L-lysine
1
1 Cited Publications
Cat. No.: HY-19527
CAS No.: 13484-66-7
Synonyms: N6-Benzyladenosine-5'-phosphate
IST5-002, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC50s: 1.5 μM for Stat5a, 3.5 μM for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML) .
Cat. No.: HY-152036A
Purity: 99.46%
SIAIS100 TFA is a potent BCR-ABL PROTAC degrader with an DC50 value of 2.7 nM. SIAIS100 TFA can be used to research chronic myeloid leukemia (CML) .
Cat. No.: HY-164393
CAS No.: 1035199-04-2
ON044580 is a non–ATP-competitive JAK2 and BCR-ABL kinases inhibitor. ON044580 inhibits wild-type (WT) and V617F mutant JAK2 with IC50 values of 1.23 μM, 1.09 μM, respectively. ON044580 also inhibits both WT and T315I mutant BCR-ABL kinases., ON044580 blocks the IL-3–mediated phosphorylation of JAK2 and STAT5, induces apoptosis in Imatinib (HY-15463)-resistant chronic myeloid leukemia (CML). ON044580 can be used for the study of CML, myelodysplasia (MDS) and other myeloproliferative neoplasms .
Synonyms: ASN05260065
iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research .
Cat. No.: HY-12083
CAS No.: 875634-01-8
PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba?F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML) .
Cat. No.: HY-162008
CAS No.: 3032432-71-3
S1g-10 is an Hsp70-Bim protein-protein interaction inhibitor and an Hsp70 ATPase inhibitor. S1g-10 binds the Hsp70 nucleotide-binding domain at the Bim interface, inhibits Bim-stimulated ATPase activity, and selectively disrupts Hsp70-Bim without affecting Hsp70-Bag3, thereby inhibiting mitophagy (Autophagy), inducing apoptosis (Apoptosis), and reducing the survival and self-renewal of CML leukemia stem cells. S1g-10 can be used for research on chronic myeloid leukemia and breast cancer .
Cat. No.: HY-13468A
CAS No.: 819812-18-5
KW-2478 hydrochloride is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 hydrochloride inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 hydrochloride weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 hydrochloride downregulates STAT3 expression. KW-2478 hydrochloride may be used in research on cancers such as CML and liver cancer .
Cat. No.: HY-125771S
CAS No.: 327178-92-7
Synonyms: 18:0 Lyso-PC-d35; LPC(18:0)-d35
Cat. No.: HY-W286743S1
CAS No.: 2699607-49-1
Synonyms: N6-(Carboxymethyl)-L-lysine-d3; Nε-(1-Carboxymethyl)-L-lysine-d3
Cat. No.: HY-N0678R
CAS No.: 118525-40-9
Synonyms: Anhydroicaritin (Standard)
Category:
Flavonols Human Gut Microbiota Metabolites Plant Flavonoids Epimedium brevicornu Maxim. Extract Phenols Polyphenols Endogenous metabolite Berberidaceae Extract
Target:
Cat. No.: HY-W700620
CAS No.: 910297-58-4
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Research Areas:
Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC50 of 46.7nM in K562 CML cells .
Cat. No.: HY-10364
CAS No.: 926922-16-9
AP24163 is a BCR-ABL kinase inhibitor. AP24163 inhibits wild-type (native) BCR-ABL and BCR-ABL-T315I with IC50 values of 7 nM and 511 nM, respectively. AP24163 can be used in the research of chronic myeloid leukemia (CML) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
