2 Results for "

CMML

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "CMML" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P99207
CAS No.: 1229575-09-0
Synonyms: KB 003

Target:  

SARS-CoV

Research Areas:  

Infection Cancer

Lenzilumab (KB 003) is a human monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies .
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Cat. No.: HY-P992389

Target:  

LILRB

Research Areas:  

Cancer

IO-202 is a high-affinity LILRB4/ILT3 binder and myeloid checkpoint inhibitor. IO-202 blocks APOE binding and LILRB4 activation to reverse T-cell suppression and enhance T-cell cytotoxicity, while eliminating LILRB4-high-expressing leukemic blasts via ADCC and ADCP mechanisms. IO-202 promotes dendritic cell maturation and antigen presentation, reshapes the phenotype of tumor-associated macrophages, and reduces myeloid-derived suppressor cells. IO-202 is widely applicable to research on relapsed/refractory acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML), and solid tumors .
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