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Caesalpinia

" in MedChemExpress (MCE) Product Catalog:

標的別:	Amyloid-β (1) Antibiotic (1) Apoptosis (3) Bacterial (1) Drug Derivative (1) HSP (1) HSV (1) Influenza Virus (2) Interleukin Related (2) JAK (1) NO Synthase (1) p38 MAPK (1) Parasite (2) Reference Standards (1) SARS-CoV (1) STAT (1) TNF Receptor (1) Xanthine Oxidase (1)
研究分野別:	Cancer (4) Infection (7) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (1)

阻害剤およびアゴニスト

蛍光色素

天然物

製品番号	製品名	Target	研究分野	構造式

HY-N0116

Hematoxylin 10+ Cited Publications Natural Black 1; Haematoxylin	Amyloid-β	Others
Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC₅₀ of 1.6 μM.

HY-N0800

Protosappanin B 2 Publications Verification (-)-Protosappanin B	Apoptosis	Cancer
Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity . Protosappanin B induces apoptosis and causes G₁ cell cycle arrest in human bladder cancer cells .

HY-113573

Protosappanin A PTA	Interleukin Related JAK STAT	Inflammation/Immunology
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3 .

HY-N7583

Norcaesalpinin E	Parasite	Infection
Norcaesalpinin E, a C-17-norcassane-type diterpene found in Caesalpinia crista, is a Plasmodium falciparum growth inhibitor with an IC₅₀ of 90 nM. Norcaesalpinin E induces dose-dependent growth inhibition of Plasmodium falciparum. Norcaesalpinin E can be used for the research of malaria .

HY-N2735

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Influenza Virus	Infection Inflammation/Immunology
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

HY-59001

Sappanchalcone	Apoptosis	Cancer
Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells .

HY-133225

Caesalpine A	Others	Others
Caesalpine A, a cassane-type diterpene, is a natural product that could be isolated from the seeds of Caesalpinia minax .

HY-N10843

4-O-Methylepisappanol	Influenza Virus	Infection
4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC₅₀ values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .

HY-403587

3-(4-Nitrophenyl)-1H-pyrazol-5(4H)-one	Others	Others
3-(4-Nitrophenyl)-1H-pyrazol-5(4H)-one is a natural product found in Caesalpinia sappan. Caesalpinia sappan contains various phytochemicals and is considered a plant with significant medicinal value .

HY-N9315

Episappanol	TNF Receptor Interleukin Related	Inflammation/Immunology
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and TNF-α secretion .

HY-N10069

Bonducellin	Bacterial	Infection
Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .

HY-N4299

Caesappanin C	HSV HSP	Metabolic Disease
Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration . Caesappanin C can effectively deactivate HSV particles and bind HSV surface glycoprotein B (gB) to inhibit membrane fusion .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	p38 MAPK	Neurological Disease Inflammation/Immunology
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-N2981

Caesalmin B	Antibiotic	Infection
Caesalmin B is a furanoditerpenoid lactone isolated from Caesalpinia minax. Caesalmin B exhibits antiviral activity .

HY-N2753

7-Acetoxybonducellpin C	Parasite	Infection
7-Acetoxybonducellpin C, a diterpenoid, is a nature product that could be isolated from the seed kernels of Caesalpinia crista. 7-Acetoxybonducellpin C has antimalarial activity .

HY-N2949

Bonducellpin D	SARS-CoV	Infection Cancer
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M ^pro and MERS-CoV M ^pro, with an K_i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .

HY-N3449

Isovouacapenol C	Others	Others
Isovouacapenol C is a Diterpenoids product that can be isolated from the roots of Caesalpinia pulcherrima .

HY-N9308

Delta-Caesalpin	Others	Others
Delta-Caesalpin is a Diterpenoids product that can be isolated from the herbs of Caesalpinia pulcherrima. .

HY-N2951

Borapetoside B (-)-Borapetoside B	Others	Others
Borapetoside B ((-)-Borapetoside B) is a Diterpenoids product that can be isolated from the herbs of Caesalpinia minax HANCE. .

HY-N1715

2-Acetoxy-3-deacetoxycaesaldekarin e	Others	Others
2-Acetoxy-3-deacetoxycaesaldekarin e (compound 11) is a furanoditerpene that can be found in Caesalpinia crista .

HY-44135

7-Hydroxy-3-(4-hydroxybenzylidene)chroman-4-one	Others	Others
7-Hydroxy-3-(4-hydroxybenzylidene)chroman-4-one, a homoisoflavonoid, can be isolated from the dried heartwood of Caesalpinia sappan .

HY-N10108

Protosappanin A dimethyl acetal	Xanthine Oxidase	Inflammation/Immunology
Protosappanin A dimethyl acetal is a homoisoflavonoid. Protosappanin A dimethyl acetal can be isolated from Caesalpinia sappan. Protosappanin A dimethyl acetal is also a competive inhibitor with significant xanthine oxidase inhibitory activity (IC₅₀=50.7 μM) .

HY-N0800R

Protosappanin B (Standard) (-)-Protosappanin B (Standard)	Reference Standards Apoptosis	Cancer
Protosappanin B (Standard) is the analytical standard of Protosappanin B. This product is intended for research and analytical applications. Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity . Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells .

HY-N18140

Caesaljapin	Drug Derivative	Others
Caesaljapin (Compound 4) is a cassane-type diterpenoid that can be isolated from plants of the genus Caesalpinia (Fabaceae) .

HY-133224

Caesalpine B	Others	Others
Caesalpine B is a Diterpenoids product that can be isolated from the seeds of Caesalpinia minax. .

HY-N7551

Neocaesalpin L	Others	Others
Neocaesalpin L is a Diterpenoids product that can be isolated from the herbs of Caesalpinia minax HANCE. .

HY-133104

Neocaesalpin O	Others	Others
Neocaesalpin O is a Diterpenoids product that can be isolated from the herbs of Caesalpinia minax HANCE. .

HY-N9049

5-O-Methyldalbergiphenol	Others	Others
5-O-Methyldalbergiphenol is a Phenols product that can be isolated from the heartwoods of Caesalpinia sappan .

HY-138267

7-O-Acetylneocaesalpin N	Others	Others
7-O-Acetylneocaesalpin N is a Diterpenoids product that can be isolated from the seeds of Caesalpinia minax Hance .

HY-N9291

4-(trans)-Acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone	Others	Others
4-(trans)-Acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone is a Phenols product that can be isolated from the herbs of Caesalpinia minax. .

HY-N13821

2α-Acetoxy-14,15-cyclopimara-7β,16-diol	NO Synthase	Inflammation/Immunology
2α-Acetoxy-14,15-cyclopimara-7β,16-diol (compound 2) is a potential anti-inflammatory agent, exhibiting weak anti-inflammatory activity by inhibiting inflammation-related NO production. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in LPS-induced RAW264.7 macrophages, with an inhibition rate of 28.1%. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol can be naturally extracted from the 70% ethanol extract of the seeds of Caesalpinia minax Hance (a plant of the Caesalpinia genus in the Fabaceae family) .

製品番号	製品名	Type

HY-N0116

Hematoxylin 10+ Cited Publications Natural Black 1; Haematoxylin	蛍光色素
Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC₅₀ of 1.6 μM.

Hematoxylin 10+ Cited Publications Natural Black 1; Haematoxylin	Classification of Application Fields Leguminosae Caesalpinia sappan L. Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Amyloid-β
Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC₅₀ of 1.6 μM.

Protosappanin B 2 Publications Verification (-)-Protosappanin B	Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Apoptosis
Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity . Protosappanin B induces apoptosis and causes G₁ cell cycle arrest in human bladder cancer cells .

Protosappanin A PTA	Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related JAK STAT
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3 .

Norcaesalpinin E	Structural Classification Leguminosae Caesalpinia crista L. Terpenoids Diterpenoids Plants Source Classification	Parasite
Norcaesalpinin E, a C-17-norcassane-type diterpene found in Caesalpinia crista, is a Plasmodium falciparum growth inhibitor with an IC₅₀ of 90 nM. Norcaesalpinin E induces dose-dependent growth inhibition of Plasmodium falciparum. Norcaesalpinin E can be used for the research of malaria .

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Source Classification	Influenza Virus
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

Sappanchalcone	Flavonoids Chalcones Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Disease Research Fields Cancer Source Classification	Apoptosis
Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells .

Caesalpine A	Leguminosae Terpenoids Diterpenoids Plants Guilandina minax (Hance) G. P. Lewis Source Classification	Others
Caesalpine A, a cassane-type diterpene, is a natural product that could be isolated from the seeds of Caesalpinia minax .

4-O-Methylepisappanol	Flavanonols Flavonoids Caesalpiniaceae Plants Source Classification	Influenza Virus
4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC₅₀ values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .

3-(4-Nitrophenyl)-1H-pyrazol-5(4H)-one	Structural Classification 天然物 Caesalpiniaceae Plants Source Classification	Others
3-(4-Nitrophenyl)-1H-pyrazol-5(4H)-one is a natural product found in Caesalpinia sappan. Caesalpinia sappan contains various phytochemicals and is considered a plant with significant medicinal value .

Episappanol	Other Terpenoids Classification of Application Fields Leguminosae Terpenoids Caesalpinia sappan L. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Source Classification	TNF Receptor Interleukin Related
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and TNF-α secretion .

Bonducellin	Flavonoids Leguminosae Caesalpinia sappan L. Plants Other Flavonoids Source Classification	Bacterial
Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .

Caesappanin C	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Other Phenylpropanoids Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields Source Classification	HSV HSP
Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration . Caesappanin C can effectively deactivate HSV particles and bind HSV surface glycoprotein B (gB) to inhibit membrane fusion .

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