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Results for "

Clausena excavata

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1)

Inhibitors & Agonists

Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10340

Clausine E Clauszoline I	Others	Cancer
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

HY-N2921

β-Amyrenonol acetate (3β)-3-(Acetyloxy)olean-12-en-11-one; 11-Oxo-β-amyrin acetate	Others	Others
β-Amyrenonol acetate ((3β)-3-(Acetyloxy)olean-12-en-11-one) is a Triterpenoids product that can be isolated from the barks of Clausena excavata .

HY-N16747

Excavatin G	Others	Others
Excavatin G is a novel coumarin compound that can be isolated from Clausena excavata. While the Clausena excavata plant itself has traditional uses such as insecticidal properties and relieving stomach pain, the specific key activities and functions of Excavatin G require targeted research and verification .

HY-N3888

Excavatin M	Others	Others
Excavatin M is a coumarin-type compound that can be isolated from the chemical constituents of the plant Clausena excavata .

HY-N20625

Myricetin 3'-rhamnoside	Others	Others
Myricetin 3'-rhamnoside is a flavonoid glycoside found in the leaves and twigs of Clausena excavata Burm. f. (Rutaceae) .

HY-N16748

Heptazoline	Others	Cardiovascular Disease
Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field .

HY-N16714

Clausine K	Others	Cancer
Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods .

HY-N3993

Clausine I	Drug Derivative	Others
Clausine I is a natural alkaloid.

Clausine E Clauszoline I	Alkaloids Classification of Application Fields Rutaceae Plants Disease Research Fields Clausena harmandiana (Pierre) Guillaumin Cancer Source Classification	Others
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

β-Amyrenonol acetate (3β)-3-(Acetyloxy)olean-12-en-11-one; 11-Oxo-β-amyrin acetate	Triterpenes Terpenoids Celastraceae Gymnosporia austroyunnanensis (S. J. Pei & Y. H. Li) M. P. Simmons Plants Source Classification	Others
β-Amyrenonol acetate ((3β)-3-(Acetyloxy)olean-12-en-11-one) is a Triterpenoids product that can be isolated from the barks of Clausena excavata .

Excavatin G	Structural Classification Flavonoids Rutaceae Plants Other Flavonoids Clausena excavata N. L. Burman Source Classification	Others
Excavatin G is a novel coumarin compound that can be isolated from Clausena excavata. While the Clausena excavata plant itself has traditional uses such as insecticidal properties and relieving stomach pain, the specific key activities and functions of Excavatin G require targeted research and verification .

Excavatin M	Structural Classification Flavonoids Rutaceae Plants Other Flavonoids Clausena excavata N. L. Burman Source Classification	Others
Excavatin M is a coumarin-type compound that can be isolated from the chemical constituents of the plant Clausena excavata .

Myricetin 3'-rhamnoside	Structural Classification Flavonols Flavonoids Rutaceae Plants Clausena excavata N. L. Burman Source Classification	Others
Myricetin 3'-rhamnoside is a flavonoid glycoside found in the leaves and twigs of Clausena excavata Burm. f. (Rutaceae) .

Heptazoline	Structural Classification Alkaloids Rutaceae Carbazole Alkaloids Plants Clausena excavata N. L. Burman Source Classification	Others
Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field .

Clausine K	Structural Classification Alkaloids Pyrrole Alkaloids Rutaceae Plants Clausena excavata N. L. Burman Source Classification	Others
Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods .

Clausine I	Structural Classification Alkaloids Rutaceae Carbazole Alkaloids Plants Clausena excavata N. L. Burman Source Classification	Drug Derivative
Clausine I is a natural alkaloid.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Clausena excavata

Inhibitors & Agonists

NaturalProducts

Natural
Products