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Results for "

DHPS inhibitor

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108314A
    GC7 Sulfate
    5+ Cited Publications

    		 DNA/RNA Synthesis Cancer
    GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
    GC7 Sulfate
  • HY-B0212
    Sulfapyridine
    2 Publications Verification

    		 Bacterial Antibiotic Infection Inflammation/Immunology
    Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .
    Sulfapyridine
  • HY-161027
    2,6-Didehydropeperomin B

    		Carnitine Palmitoyltransferase (CPT) Apoptosis Cancer
    DHP-B is an Ecolignan-type compound and covalent, selective CPT1A inhibitor with a Kd of 1.62 μM. DHP-B can be isolated from the plant Peperomia dindygulensis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction. DHP-B triggers Apoptosis. DHP-B exhibits anti-CRC activity .
    2,6-Didehydropeperomin B
  • HY-108314
    GC-7

    		DNA/RNA Synthesis Cancer
    GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
    GC-7
  • HY-B0212R
    Sulfapyridine (Standard)

    		Reference Standards Bacterial Antibiotic Infection Inflammation/Immunology
    Sulfapyridine (Standard) is the analytical standard of Sulfapyridine. This product is intended for research and analytical applications. Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .
    Sulfapyridine (Standard)
  • HY-147721
    Dihydropteroate synthase-IN-1

    		Bacterial Infection
    Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material .
    Dihydropteroate synthase-IN-1
  • HY-B0273B
    Sulfadiazine 100 µg/mL in methanol
    Maximum Cited Publications
    8 Publications Verification

    		 Parasite Bacterial Environmental Pollutants Infection
    Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection .
    Sulfadiazine 100 µg/mL in methanol
  • HY-175828
    DHPS-IN-2

    		DNA/RNA Synthesis Cancer
    DHPS-IN-2 is an allosteric deoxyhypusine synthase (DHPS) inhibitor with an IC50 of 70 nM and a Kd of 26.4 μM. DHPS-IN-2 significantly suppresses melanoma cell migration and invasiveness in vitro and exhibits potent anti-tumor efficacy in an A375 cell zebrafish xenograft model. DHPS-IN-2 can be used for the study of melanoma .
    DHPS-IN-2
  • HY-155804
    RIP1 kinase inhibitor 8

    		Necroptosis RIP kinase Inflammation/Immunology
    RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species .
    RIP1 kinase inhibitor 8
  • HY-172109
    DNA Gyrase-IN-15

    		DNA/RNA Synthesis Infection
    DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis .
    DNA Gyrase-IN-15
  • HY-135062
    9-Methylguanine

    		Bacterial Infection
    9-Methylguanine, a derivative of 8-mercaptoguanine, is a dihydropteroate synthase (DHPS) inhibitor with a Kd of 58 μM for E.coli DHPS (EcDHPS) .
    9-Methylguanine
  • HY-182529
    DHPS-IN-3

    		DNA/RNA Synthesis Cancer
    DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC50 of 0.0092 μM at 14 μM NAD and an IC50 of 0.069 μM at 250 μM NAD. DHPS-IN-3 is applicable for cancer research .
    DHPS-IN-3
  • HY-108314AR
    GC7 Sulfate (Standard)

    		Reference Standards DNA/RNA Synthesis Cancer
    GC7 Sulfate (Standard) is the analytical standard of GC7 Sulfate (HY-108314A). This product is intended for research and analytical applications. GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
    GC7 Sulfate (Standard)

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