1 Result for "

DOTA-RGDfK dimer

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "DOTA-RGDfK dimer" in MCE Product Catalog:

Cat. No.: HY-P3335
CAS No.: 250612-06-7
Synonyms: DOTA-RGDfK dimer
SU015 (DOTA-RGDfK dimer) is a Integrin αvβ5 and αvβ3 antagonist. SU015 exhibits comparable affinity for αvβ5 and αvβ3, with relatively higher potency and specificity compared to other integrins. SU015 inhibits αvβ3-mediated cell adhesion to fibrinogen, αvβ3-mediated adhesion of activated platelets to osteopontin, and αvβ5-mediated cell adhesion to vitronectin. SU015 shows potent inhibitory effects on FGF2-induced angiogenesis in the CAM model. SU015 carries a linker arm available for radioisotope conjugation, and acts as a target-specific radioreagent when labeled with 90Y (i.e., RP697) or 177Lu (i.e., RP688). SU015 can be used in studies related to tumor metastasis and tumors .
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