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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
879 Results for "
E3 ligand-linker
" in MedChemExpress (MCE) Product Catalog:
Products (879)
879 Results for "E3 ligand-linker" in MCE Product Catalog:
5
5 Cited Publications
MT-802 is a BTK PROTAC degrader. MT-802 degrades wild-type BTK (DC50 = 14.6 nM) and BTK mutants including E41K, C481S (DC50 = 14.9 nM), C481R, C481Y, C481T, C481F, L528W, and inhibits their Y223 phosphorylation. BI-4732 can be used for the study of Ibrutinib (HY-10997)-resistant chronic lymphocytic leukemia (CLL). (Pink: BTK ligand (HY-150885), Blue: CRBN Ligand (HY-14658), Black: Linker (HY-141371), E3 ligase ligand-linker conjugate (HY-176340)) .
2
2 Cited Publications
Synonyms: VH032-PEG4-NH2 hydrochloride; VHL ligand-linker Conjugates 4 hydrochloride; E3 ligase ligand-linker Conjugates 7
Research Areas:
(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
2
2 Cited Publications
Synonyms: VH032-PEG4-NH2; VHL ligand-linker Conjugates 4 ; E3 ligase ligand-linker Conjugates 7 Free Base
Research Areas:
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
2
2 Cited Publications
Synonyms: VH032-PEG4-N3; VHL ligand-linker Conjugates 5; E3 ligase ligand-linker Conjugates 4
Research Areas:
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
1
1 Cited Publications
Cat. No.: HY-128832
Purity: 99.19%
Synonyms: MDM2 ligand-linker Conjugates 1; E3 ligase ligand-linker Conjugates 48
Research Areas:
Nutlin-C1-amido-PEG4-C2-N3 (MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48) is an E3 ligase ligand-linker conjugate that can be used for the synthesis of PROTACs .
1
1 Cited Publications
Synonyms: VH032-PEG2-N3; VHL ligand-linker Conjugates 6; E3 ligase ligand-linker Conjugates 13
Research Areas:
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-N3 can be used for the synthesis of PROTACs .
1
1 Cited Publications
Synonyms: Cereblon ligand-linker Conjugates 4; E3 ligase ligand-linker Conjugates 18
Research Areas:
Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker .
1
1 Cited Publications
Synonyms: Cereblon ligand -linker Conjugates 2 TFA; E3 Ligase ligand-linker Conjugates 20 TFA
Research Areas:
Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
1
1 Cited Publications
Synonyms: VH032-PEG2-C4-Cl; VHL ligand-linker Conjugates 7; E3 ligase ligand-linker Conjugates 10
Research Areas:
(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .
1
1 Cited Publications
Synonyms: VH032-C6-PEG3-C4-Cl; VHL ligand-linker Conjugates 12; E3 ligase ligand-linker Conjugates 8
Research Areas:
(S,R,S)-AHPC-C6-PEG3-C4-Cl (VH032-C6-PEG3-C4-Cl) is a conjugate of ligands for E3 and 20-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-C6-PEG3-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .
1
1 Cited Publications
Research Areas:
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-W1006706
CAS No.: 2502189-47-9
Research Areas:
E3 Ligase Ligand-linker Conjugate 157 is the conjugate composed of the E3 ligase ligand and the linker. E3 Ligase Ligand-linker Conjugate 157 can be used for synthesis of PROTAC degrader KT-253 (HY-170451) .
Cat. No.: HY-KT001
Research Areas:
E3 Ligase Ligand-Linker Conjugate Kit is a series of synthesized compounds that incorporate an E3 ligase ligand and a linker used in PROTAC technology.
Cat. No.: HY-179244
CAS No.: 2139329-71-6
Research Areas:
E3 Ligase Ligand-linker Conjugate 215 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 215 can be used to synthesize STAT3 PROTAC Degrader S3D5 (HY-179243) .
Cat. No.: HY-168659
Research Areas:
E3 Ligase Ligand-linker Conjugate 130 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 130 can be used to synthesize YJ1206 (HY-16855) .
Cat. No.: HY-173436
Research Areas:
E3 Ligase Ligand-linker Conjugate 179 is an E3 ubiquitinase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 179 can be used to synthesize JV8 (HY-173433) .
Cat. No.: HY-176138
CAS No.: 3030500-92-3
Research Areas:
E3 Ligase Ligand-linker Conjugate 185 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 185 can be used to synthesize RP03707 (HY-176134) .
Cat. No.: HY-168871
Research Areas:
E3 Ligase Ligand-linker Conjugate 161 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 161 can be used to synthesize Tamoxifen-PEG-Clozapine (HY-168869) .
Cat. No.: HY-168701
Research Areas:
E3 Ligase Ligand-linker Conjugate 149 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 149 can be used to synthesize Setidegrasib (HY-148273) .
Cat. No.: HY-168866
Research Areas:
E3 Ligase Ligand-linker Conjugate 160 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 160 can be used to synthesize FF2049 (HY-168863) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
