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GluT substrate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GLUT (3) EAAT (1) Fluorescent Dye (2) NF-κB (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Targets Recommended: GLUT MARCKS mGluR iGluR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-175674

NGI-235	NF-κB Toll-like Receptor (TLR) GLUT	Inflammation/Immunology
NGI-235 is an STT3A-selective oligosaccharyltransferase complex OST-A inhibitor. NGI-235 preferentially inhibits OST-A catalytic activity, impairing N-glycosylation of OST-A substrates. NGI-235 causes the hypoglycosylation of both TLR4, GLUT1 and inhibits NF-κB signaling. NGI-235 can be used for the research of inflammation .

HY-100838

cis-α-(Carboxycyclopropyl)glycine L-CCG III	EAAT	Neurological Disease
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC₅₀: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na ⁺-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes .

HY-D3199

NIR‐fluorescent glucose	Fluorescent Dye GLUT	Metabolic Disease
NIR-fluorescent glucose is a functional glucose-based fluorescent imaging agent. Conjugated with the nitrobenzoselenadiazole-based SCOTfluor (compound 9), NIR-fluorescent glucose acts as a substrate for *GLUT4* and *GLUT2* transporters. NIR-fluorescent glucose enables the visualization of glucose uptake in live cells and in vivo .

HY-D3410

CDr17	Fluorescent Dye GLUT	Others
CDr17 is a *GLUT1* substrate and selective fluorescent dye staining M1 microphages. CDr17 utilizes the Gating-Oriented Live-cell Distinction (GOLD) mechanism to enter M1 macrophages (Ex/Em = 646/662 nm) .

Cat. No.	Product Name	Type

HY-D3199

NIR‐fluorescent glucose	Fluorescent Dyes
NIR-fluorescent glucose is a functional glucose-based fluorescent imaging agent. Conjugated with the nitrobenzoselenadiazole-based SCOTfluor (compound 9), NIR-fluorescent glucose acts as a substrate for *GLUT4* and *GLUT2* transporters. NIR-fluorescent glucose enables the visualization of glucose uptake in live cells and in vivo .

HY-D3410

CDr17	Fluorescent Dyes
CDr17 is a *GLUT1* substrate and selective fluorescent dye staining M1 microphages. CDr17 utilizes the Gating-Oriented Live-cell Distinction (GOLD) mechanism to enter M1 macrophages (Ex/Em = 646/662 nm) .

Cat. No.	Product Name	Target	Research Area

HY-100838

cis-α-(Carboxycyclopropyl)glycine L-CCG III	EAAT	Neurological Disease
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC₅₀: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na ⁺-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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