2894135-13-6
2894135-13-6
Chemical Structure
Pomalidomide-β-D-glucose
- CAS No.: 2894135-13-6
- Formula:C19H21N3O9
- Molecular Weight:435.38
InChIKey: QCVLAQDVVQDFNM-OCSWZFFWSA-N
SMILES: O=C(NC1=O)CCC1N2C(C3=C(N[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)C=CC=C3C2=O)=O
Biological Activity: Pomalidomide-β-D-glucose is an orally active Molecular glue degrader of IKZF1 and CK1α. Pomalidomide-β-D-glucose forms a ternary complex with CRBN and substrate proteins, inducing ubiquitination and proteasomal degradation of IKZF1 and CK1α. Pomalidomide-β-D-glucose undergoes GLUT1-mediated cellular uptake. Pomalidomide-β-D-glucose can be used for research on multiple myeloma[1].
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Pomalidomide-β-D-glucose | Pomalidomide-β-D-glucose is an orally active Molecular glue degrader of IKZF1 and CK1α. Pomalidomide-β-D-glucose forms a ternary complex with CRBN and substrate proteins, inducing ubiquitination and proteasomal degradation of IKZF1 and CK1α. Pomalidomide-β-D-glucose undergoes GLUT1-mediated cellular uptake. Pomalidomide-β-D-glucose can be used for research on multiple myeloma. | |||||||||||||||||||||
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