1. cis-α-(Carboxycyclopropyl)glycine

cis-α-(Carboxycyclopropyl)glycine  (Synonyms: L-CCG III)

Cat. No.: HY-100838
Handling Instructions

cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes.

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cis-α-(Carboxycyclopropyl)glycine Chemical Structure

cis-α-(Carboxycyclopropyl)glycine Chemical Structure

CAS No. : 117857-95-1

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Description

cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes[1][2].

IC50 & Target

Glutamate transporters (GluT)[1]

Molecular Weight

159.14

Formula

C6H9NO4

CAS No.
SMILES

[H][C@@]1([C@H](N)C(O)=O)[C@H](C(O)=O)C1

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cis-α-(Carboxycyclopropyl)glycine
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HY-100838
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