cis-α-(Carboxycyclopropyl)glycine
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes.
For research use only. We do not sell to patients.
- CAS No.: 117857-95-1
- Formula: C6H9NO4
- Molecular Weight:159.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-107522
DL-TBOA -
HY-107521
TFB-TBOA -
HY-D0236
Congo Red -
HY-100784
Dihydrokainic acid -
HY-B1102
Evans Blue -
HY-100801
L-threo-3-Hydroxyaspartic acid -
HY-D0214
Acid Red 94 sodium -
HY-12741
LDN-212320 -
HY-107523
WAY-213613 -
HY-D0214R
Acid Red 94 sodium (Standard) -
HY-100836
trans-4-Carboxy-L-proline -
HY-100801R
L-threo-3-Hydroxyaspartic acid (Standard)
Biological Activity
Description
IC50 & Target
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EAAT1 |
EAAT2 |
Chemical Information
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CAS No. 117857-95-1
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Molecular Weight 159.14
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Formula C6H9NO4
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Synonyms
L-CCG III
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Y Nakamura, et al. (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology. 1993 Sep;32(9):833-7. [Content Brief]
[2]. Charbel El-Hajj Moussa, et al. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochem Res. 2002 Feb;27(1-2):27-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cis-α-(Carboxycyclopropyl)glycine Related Classifications
HY-100838 Related Classifications
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