117857-95-1
Chemical Structure
cis-α-(Carboxycyclopropyl)glycine
Synonym(s): L-CCG III
- CAS No.: 117857-95-1
- Formula:C6H9NO4
- Molecular Weight:159.14
IUPAC Name: (1R,2S)-2-((S)-amino(carboxy)methyl)cyclopropane-1-carboxylic acid
InChIKey: GZOVEPYOCJWRFC-NUNKFHFFSA-N
SMILES: [H][C@@]1([C@H](N)C(O)=O)[C@H](C(O)=O)C1
Biological Activity: cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes[1][2].
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cis-α-(Carboxycyclopropyl)glycine | cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes. | |||||||||||||||||||||
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- [1]. Y Nakamura, et al. (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology. 1993 Sep;32(9):833-7. [Content Brief]
- [2]. Charbel El-Hajj Moussa, et al. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochem Res. 2002 Feb;27(1-2):27-35. [Content Brief]
Keywords
