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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
Heat Shock Protein 70
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "Heat Shock Protein 70" in MCE Product Catalog:
29
29 Publications Verification
Cat. No.: HY-17504
CAS No.: 147098-20-2
Synonyms: Rosuvastatin hemicalcium; ZD 4522 Calcium
Research Areas:
Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
29
Research Areas:
Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
29
29 Publications Verification
Cat. No.: HY-17504B
CAS No.: 147098-18-8
Synonyms: ZD 4522 Sodium; X-Plended Sodium; Crestor Sodium
Research Areas:
Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
13
13 Cited Publications
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages .
6
6 Cited Publications
Target:
Research Areas:
TRC051384 is a potent inducer of heat shock protein 70 (HSP70). TRC051384 exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 can be used for the research of ischemic stroke .
3
3 Cited Publications
Cat. No.: HY-P73915A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HSPA8; Epididymis Secretory Sperm Binding Protein Li 72p; Prev. HSPA10; Constitutive Heat Shock Protein 70; HSC70; Epididymis Luminal Protein 33; HSP73; Heat Shock Cognate Protein 54; Heat Shock Cognate 71 KDa Protein; Heat Shock 70kd Protein 10; HSC71; H
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-17504BS
CAS No.: 1279031-70-7
Rosuvastatin-d3 sodium is the deuterated-labeled Rosuvastatin Sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
1
1 Cited Publications
Cat. No.: HY-P80496
Synonyms: GRP78, HSPA5, Endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated Protein, Binding-immunoglobulin Protein, Heat Shock Protein 70 family Protein 5, Heat Shock Protein family A member 5, Immunoglobulin heavy chain-binding Protein, GRP-78, BiP, HSP70 family Protein 5
1
1 Cited Publications
Cat. No.: HY-P73915
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA8; Epididymis Secretory Sperm Binding Protein Li 72p; Prev. HSPA10; Constitutive Heat Shock Protein 70; HSC70; Epididymis Luminal Protein 33; HSP73; Heat Shock Cognate Protein 54; Heat Shock Cognate 71 KDa Protein; Heat Shock 70kd Protein 10; HSC71; Heat Shock 70kD Protein 8; Lipopolysaccharide-Associated Protein 1; HSPA8 Protein; Heat Shock Protein Family A Member 8; CDNA FLJ77848; Heat Shock 70 KDa Protein 8; HEL-S-72p; Heat Shock 70kDa Protein 8; HSC54; LPS-Associated Protein 1; HSP71; HEL-33; NIP71; LAP-1; LAP1; Heat Shock Protein Family A (Hsp70) Member 8; N-Myristoyltransferase Inhibitor Protein 71
Species:
Human
Source:
E. coli
Category:
Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Cancer Citrus medica Linn. var. sarcodactylis (Noot.) Swingle
Target:
JG-231 is an allosteric inhibitor of heat shock protein 70 (Hsp70). JG - 231 inhibits the binding of Hsp70 and BAG family proteins, including inhibition of Hsp70 and BAG1 with a Ki of 0.11 μM. JG-231 inhibits proliferation of tumor cells and induces apoptosis. JG-231 has antitumor activity .
Research Areas:
AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .
Cat. No.: HY-17504R
CAS No.: 147098-20-2
Synonyms: Rosuvastatin hemicalcium (Standard); ZD 4522 Calcium (Standard)
Research Areas:
Rosuvastatin (Calcium) (Standard) is the analytical standard of Rosuvastatin (Calcium). This product is intended for research and analytical applications. Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
Synonyms: 5,7-Dimethoxycoumarin (Standard); Limettin (Standard)
Category:
Rutaceae Coumarins Phenylpropanoids Plants Citrus medica Linn. var. sarcodactylis (Noot.) Swingle
Target:
Cat. No.: HY-148745
CAS No.: 2241517-83-7
Target:
Research Areas:
JG-258 is an inactive negative control for Hsp70 inhibitors. JG-258 is an inactive structural analog of JG-98 (HY-117282), an allosteric inhibitor of heat shock protein 70 (Hsp70) with demonstrated anticancer activity. JG-258 can be used in cancer-related research .
Cat. No.: HY-17504AS1
CAS No.: 2070009-40-2
Synonyms: ZD 4522-d6
Cat. No.: HY-17504BS1
CAS No.: 2070009-41-3
Cat. No.: HY-178462
Target:
Research Areas:
Hsp70/FoxM1-IN-1 (Compound 7d) is a potent heat shock protein 70 (Hsp70) and Forkhead box M1 (FoxM1) dual inhibitor. Hsp70/FoxM1-IN-1 demonstrates significant antiproliferative and pro-apoptotic effects in multiple solid tumor models (e.g., breast, colorectal cancer), particularly for tumors co-overexpressing Hsp70/FoxM1 .
Cat. No.: HY-17504AS
CAS No.: 1133429-16-9
Synonyms: ZD 4522 d3
Rosuvastatin-d3 is the deuterated-labeled Rosuvastatin (HY-17504A). Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
Cat. No.: HY-124109
CAS No.: 1333327-56-2
Target:
Research Areas:
TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). TRC051384 hydrochloride exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 hydrochloride can be used for the research of ischemic stroke .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
