2241517-83-7
2241517-83-7
Chemical Structure
JG-258
- CAS No.: 2241517-83-7
- Formula:C20H22ClN3OS3
- Molecular Weight:452.06
IUPAC Name: (E)-3-(2,6-dichloro-4-((4-(3-(2,2-dimethyl-1-propoxypropyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid
InChIKey: PKMOCFPDFBAKKL-KPJFUTMLSA-M
SMILES: O=C1/C(S/C(N1CC)=C\C2=[N+](C=CS2)CC3=CC=CC=C3)=C4N(CCS/4)C.[Cl-]
Biological Activity: JG-258 is an inactive negative control for Hsp70 inhibitors. JG-258 is an inactive structural analog of JG-98 (HY-117282), an allosteric inhibitor of heat shock protein 70 (Hsp70) with demonstrated anticancer activity. JG-258 can be used in cancer-related research[1][2].
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JG-258 | JG-258 is an inactive negative control for Hsp70 inhibitors. JG-258 is an inactive structural analog of JG-98 (HY-117282), an allosteric inhibitor of heat shock protein 70 (Hsp70) with demonstrated anticancer activity. JG-258 can be used in cancer-related research. | |||||||||||||||||||||
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References
- [1]. Hong SK, et al. Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. International journal of molecular sciences. 2022 Jan 19;23(3):1063. [Content Brief]
- [2]. Davis AK, et al. Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase. Mol Pharmacol. 2020 Sep;98(3):243-249.
