487-06-9
Chemical Structure
Citropten
Synonym(s): 5,7-Dimethoxycoumarin; Limettin
- CAS No.: 487-06-9
- Formula:C11H10O4
- Molecular Weight:206.20
IUPAC Name: 5,7-dimethoxy-2H-chromen-2-one
InChIKey: NXJCRELRQHZBQA-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C(OC)=CC(OC)=C2)C=C1
Biological Activity: Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis[1] [2] [3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Citropten | 99.69% | Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis . | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Citropten (Standard) | 98.67% | Citropten (Standard) is the analytical standard of Citropten. This product is intended for research and analytical applications. Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis . | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Wolny D, et al. Antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells. Acta Pol Pharm. 2014 Nov-Dec;71(6):1056-9. [Content Brief]
- [2]. Lee HS, et al. Ameliorative Effect of Citropten Isolated from Citrusaurantifolia Peel Extract as a Modulator of T Cell and Intestinal Epithelial Cell Activity in DSS-Induced Colitis. Molecules. 2022 Jul 20;27(14):4633. [Content Brief]
- [3]. Yang W, et al. 5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels. Saudi J Biol Sci. 2018 Feb;25(2):253-258. [Content Brief]
Keywords
