487-06-9
487-06-9
Chemical Structure
Citropten
Synonym(s): 5,7-Dimethoxycoumarin; Limettin
- CAS No.: 487-06-9
- Formula:C11H10O4
- Molecular Weight:206.20
IUPAC Name: 5,7-dimethoxy-2H-chromen-2-one
InChIKey: NXJCRELRQHZBQA-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C(OC)=CC(OC)=C2)C=C1
Biological Activity: Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis[1] [2] [3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Citropten | 99.69% | Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis . | ||||||||||||||||||||
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Citropten (Standard) | 98.67% | Citropten (Standard) is the analytical standard of Citropten. This product is intended for research and analytical applications. Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis . | ||||||||||||||||||||
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Br-Mmc | 98.56% | Br-Mmc (4-Bromomethyl-7-methoxycoumarin) is often used as fluorescent label for the determination of compounds possessing a carboxylic group. Br-Mmc is used for the determination fatty acids by TLC or HPLC. | ||||||||||||||||||||
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4-Methylherniarin | 99.71% | 4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label, has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 values of 11.76 μg/ml and 13.47 μg/ml. | ||||||||||||||||||||
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Scoparone (Standard) | 98.74% | Scoparone (Standard) is the analytical standard of Scoparone. This product is intended for research and analytical applications. Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities. | ||||||||||||||||||||
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Scopoletin (Standard) | 98.84% | Scopoletin (Standard) is the analytical standard of Scopoletin. This product is intended for research and analytical applications. Scopoletin is an inhibitor of acetylcholinesterase (AChE). | ||||||||||||||||||||
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Isoscopoletin | 99.92% | Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication. Isoscopoletin exhibits anti-inflammatory activity through inhibition of MAPK/NF-κB/STAT/AKT signaling pathway. | ||||||||||||||||||||
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5-Hydroxy-7-methoxycoumarin | 5-Hydroxy-7-methoxycoumarin is a coumarin compound present in the whole plant of Euphorbia kansuensis, with an IC50 > 40 μM against five human cancer cell lines. | |||||||||||||||||||||
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7,8-Dimethoxycoumarin | 99.75% | 7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H+/K+-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis. | ||||||||||||||||||||
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7-Hydroxy-5-methoxycoumarin | 7-Hydroxy-5-methoxycoumarin is a phloroglucinol-type furocoumarins, a potent naturally-occurring insect antifeedant. | |||||||||||||||||||||
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4-Methoxycoumarin | 99.44% | 4-Methoxycoumarin (Compound 6) shows antibacterial activity of against R. solanacearum. | ||||||||||||||||||||
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6-Methoxy-4-methylcoumarin | 99.00% | 6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo. | ||||||||||||||||||||
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References
- [1]. Wolny D, et al. Antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells. Acta Pol Pharm. 2014 Nov-Dec;71(6):1056-9. [Content Brief]
- [2]. Lee HS, et al. Ameliorative Effect of Citropten Isolated from Citrusaurantifolia Peel Extract as a Modulator of T Cell and Intestinal Epithelial Cell Activity in DSS-Induced Colitis. Molecules. 2022 Jul 20;27(14):4633. [Content Brief]
- [3]. Yang W, et al. 5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels. Saudi J Biol Sci. 2018 Feb;25(2):253-258. [Content Brief]
