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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Hepatocyte nuclear factor 4 alpha
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Hepatocyte nuclear factor 4 alpha" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-108469
CAS No.: 93987-29-2
Target:
Research Areas:
BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes .
1
1 Cited Publications
Cat. No.: HY-P701139A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HNF4A; TCF-14; Prev. TCF14; Hepatocyte nuclear factor 4 4 alpha Variant 4; Prev. MODY1; Hepatocyte nuclear factor 4 4 alpha Variant 1; Prev. MODY; Hepatocyte nuclear factor 4 4 alpha Variant 2; NR2A1; Truncated Hepatocyte nuclear factor 1 alpha; HNF4; HNF
Species:
Human
Source:
HEK293
Cat. No.: HY-119971
CAS No.: 337506-43-1
Target:
Research Areas:
BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes .
Cat. No.: HY-P701139
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HNF4A; TCF-14; Prev. TCF14; Hepatocyte nuclear factor 4 4 alpha Variant 4; Prev. MODY1; Hepatocyte nuclear factor 4 4 alpha Variant 1; Prev. MODY; Hepatocyte nuclear factor 4 4 alpha Variant 2; NR2A1; Truncated Hepatocyte nuclear factor 1 alpha; HNF4; HNF
Species:
Human
Source:
HEK293
Cat. No.: HY-108469R
CAS No.: 93987-29-2
Research Areas:
BI-6015 (Standard) is the analytical standard of BI-6015 (HY-108469). This product is intended for research and analytical applications. BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes .
Cat. No.: HY-18314B
CAS No.: 504433-24-3
Target:
Research Areas:
(Z)-GW 441756 is a hepatocyte nuclear factor 4α (HNF4α) activator, with an EC50 of 9.2 μM and a Ka of 4.6 μM in human systems. (Z)-GW 441756 directly interacts with the ligand-binding domain of HNF4α via persistent hydrogen bonds and hydrophobic interactions within the binding pocket. (Z)-GW 441756 reduces the accumulation of triglycerides and total cholesterol. (Z)-GW 441756 inhibits ferroptosis through a non-antioxidant mechanism. (Z)-GW 441756 decreases plasma triglyceride and total cholesterol levels in animal models of hyperlipidemia. (Z)-GW 441756 can be used in studies related to hyperlipidemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
