118 Results for "

ICR mice

" in MedChemExpress (MCE) Product Catalog:
Products (118)

118 Results for "ICR mice" in MCE Product Catalog:

8
Sappanone A
Sappanone A
0 Images
8 Publications Verification
Cat. No.: HY-113556
CAS No.: 102067-84-5
Purity:  99.87%
Category:  

Flavonoids Leguminosae Caesalpinia sappan L. Plants Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

Phosphodiesterase (PDE) NF-κB Keap1-Nrf2 Reactive Oxygen Species (ROS) TNF Receptor Nuclear Factor of activated T Cells (NFAT) Akt ERK p38 MAPK NO Synthase Interleukin Related COX JNK

Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular .
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7
Lysophosphatidylcholines
Lysophosphatidylcholines
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7 Cited Publications
Cat. No.: HY-139414
CAS No.: 9008-30-4
Purity:  ≥99.0%
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis .
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7
Resibufogenin
Resibufogenin
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7 Cited Publications
Cat. No.: HY-N0815
CAS No.: 465-39-4
Synonyms: Bufogenin; Recibufogenin
Category:  

Animals Disease Research Fields Cancer Steroids

Target:  

PI3K Akt NF-κB AP-1 GSK-3 CDK

Resibufogenin is an orally active anticancer agent. Resibufogenin can be extracted from toad venom. Resibufogenin blocks signaling pathways such as PI3K/Akt, NF-κB, AP-1, activates GSK-3β, and regulates cyclin D1. Resibufogenin can activate central neurons. Resibufogenin has anti-inflammatory activity. Resibufogenin has anti-tumor effects on a variety of tumors such as multiple myeloma, renal cancer, colorectal cancer, pancreatic cancer, and glioma .
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5
Crebanine
Crebanine
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5 Cited Publications
Cat. No.: HY-N2255
CAS No.: 25127-29-1
Category:  

Cardiovascular Disease Alkaloids Stephania venosa Other Alkaloids Plants Disease Research Fields Inflammation/Immunology Menispermaceae

Target:  

Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial

Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC50 of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na + current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .
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3
Demethyleneberberine chloride
Demethyleneberberine chloride
0 Images
3 Cited Publications
Cat. No.: HY-N0592A
CAS No.: 16705-03-6
Category:  

Alkaloids Phellodendron amurense Rupr. Other Alkaloids Rutaceae Phenols Polyphenols Plants

Target:  

NF-κB AMPK Reactive Oxygen Species (ROS) p38 MAPK

Demethyleneberberine chloride is a blood-brain barrier-permeable antioxidant. Demethyleneberberine chloride exerts antioxidant effects by targeting mitochondria, activates the AMPK signaling pathway to regulate lipid metabolism, and inhibits inflammation-related pathways such as NF-κB and MAPK. Demethyleneberberine chloride can be used in the research of inflammatory and other diseases .
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3
Atractyloside A
Atractyloside A
0 Images
3 Cited Publications
Cat. No.: HY-N0237
CAS No.: 126054-77-1
Category:  

Terpenoids Sesquiterpenes Other Diseases Plants Compositae Disease Research Fields Erythrina sigmoidea Hua

Target:  

Toll-like Receptor (TLR) MyD88 NF-κB Mitochondrial Metabolism Interleukin Related Aquaporin

Atractyloside A is an orally active inhibitor of the TLR4/MyD88/NF-κB signaling pathway and also an opener of the mitochondrial permeability transition pore (MPTP). Atractyloside A interferes with the activation of the TLR4/MyD88/NF-κB pathway, thereby inhibiting intestinal inflammatory responses. Atractyloside A reverses mucin synthesis impairment, improves intestinal barrier integrity, and restores homeostasis by altering the composition of the gut microbiota. Atractyloside A can be used in studies related to spleen deficiency diarrhea and myocardial injury .
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2
Tubeimoside III
Tubeimoside III
0 Images
2 Cited Publications
Cat. No.: HY-N2542
CAS No.: 115810-13-4
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related NO Synthase

Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an LD50 of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .
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2
Pectolinarigenin
Pectolinarigenin
0 Images
2 Cited Publications
Cat. No.: HY-N0493
CAS No.: 520-12-7
Category:  

Flavonoids Flavones Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy

Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G2/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma .
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1
3,3-Dimethyl-1-butanol
3,3-Dimethyl-1-butanol
0 Images
1 Cited Publications
Cat. No.: HY-W012977
CAS No.: 624-95-3
Synonyms: DMB; Neohexanol
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite NF-κB TGF-beta/Smad

3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) .
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1
Octahydrocurcumin
Octahydrocurcumin
0 Images
1 Cited Publications
Cat. No.: HY-N0894
CAS No.: 36062-07-4
Synonyms: Hexahydrobisdemethoxycurcumin
Category:  

Other Diseases Phenols Polyphenols Plants Curcuma longa Disease Research Fields Zingiberaceae

Target:  

Apoptosis MAP4K NF-κB COX

Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively .
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1
Gigantol
Gigantol
0 Images
1 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
Category:  

Orchidaceae Other Diseases Phenols Polyphenols Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.

Target:  

Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3

Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .
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1
Peptide P60
Peptide P60
0 Images
1 Cited Publications
Cat. No.: HY-P1684
CAS No.: 1319725-20-6
Synonyms: FOXP3 inhibitor P60
Target:  

FOXP NF-κB Nuclear Factor of activated T Cells (NFAT)

Research Areas:  

Infection Inflammation/Immunology Cancer

Peptide P60 is a FOXP3 inhibitor. Peptide P60 reduces the nuclear translocation of FOXP3 and impairs FOXP3-mediated inhibition of NF-κB and NFAT activity. Peptide P60 inhibits the immunosuppressive activity of regulatory T cells and restores the proliferation and activation of effector T cells. Peptide P60 induces lymphoproliferative autoimmune syndrome in neonatal ICR mice and reduces the number of CD4 +CD25 +Foxp3 + T cells in the spleen. Peptide P60 enhances the efficacy of AH1 (HY-P4193) peptide vaccine and recombinant adenovirus-based HCV NS3 vaccine in BALB/c mice, including protective effects against CT26 tumor implantation. Peptide P60 can be used in studies related to tumor immunity, viral infection and lymphoproliferative autoimmune syndrome .
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1
Forsythoside E
Forsythoside E
0 Images
1 Cited Publications
Cat. No.: HY-N2173
CAS No.: 93675-88-8
Category:  

Oleaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields Inflammation/Immunology

Target:  

Others

Forsythoside E is a phenylethanoid glycoside compound. Forsythoside E can be isolated from Shuanghuanglian. Forsythoside E does not induce vascular leakage or promote histamine release in mice. Forsythoside E does not cause pseudo-allergic reactions .
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1
Mulberroside C
Mulberroside C
0 Images
1 Cited Publications
Cat. No.: HY-N0620
CAS No.: 102841-43-0
Category:  

Infection other families Monophenols Phenols Plants Moraceae Disease Research Fields Morus alba Linn.

Target:  

HCV Enterovirus PERK Calcium Channel P-selectin HCN Channel Ras ERK DNA/RNA Synthesis

Mulberroside C is one of the main bioactive components in white mulberry (Morus alba L.). Mulberroside C exhibits antiplatelet, antiviral and neutrophil-regulating activities, and binds to EV-A71 VP1 with a Kd value of 1.289 nM. Mulberroside C reduces the phosphorylation level of ERK, promotes the phosphorylation of IP3RI at the Ser 1756 site, and decreases calcium influx and calcium mobilization. Mulberroside C inhibits the expression of P-selectin (P-selectin). Mulberroside C upregulates the cyclic nucleotide signaling pathway in human platelets. Mulberroside C binds to IL-23R, upregulates the expression of G-CSF, GM-CSF and RASGRP1, and activates the RAS/ERK signaling pathway. Mulberroside C promotes neutrophil maturation, accelerates the recovery of leukopenia, and enhances the antibacterial activity of neutrophils. Mulberroside C inhibits the replication of hepatitis C virus in replicon cells. Mulberroside C prevents the uncoating and genome release of EV-A71, and inhibits the synthesis of viral proteins and RNA. Mulberroside C can be used in studies related to thrombosis-mediated cardiovascular diseases, chemotherapy- and radiotherapy-induced leukopenia, hepatitis C virus infection, and hand, foot and mouth disease .
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CBPD-409
CBPD-409
0 Images
Cat. No.: HY-158113
CAS No.: 3037549-86-0
Target:  

Histone Acetyltransferase PROTACs

Research Areas:  

Cancer

CBPD-409 is an orally active PROTAC degrader for CBP/p300, with DC50 of 0.2–0.4 nM. CBPD-409 exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP and 22Rv1, with IC50s of 1.2–2.0 nM. CBPD-409 exhibits antitumor efficacy (Red: CBP inhibitor GNE049 (HY-108435); Blue: CRBN/cullin 4A Thalidomide (HY-14658); Black: Linker) .
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D-Psicose
D-Psicose
0 Images
Cat. No.: HY-N9914
CAS No.: 551-68-8
Synonyms: D-Allulose
Category:  

Human Gut Microbiota Metabolites Endogenous metabolite

Target:  

p38 MAPK NF-κB

D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease .
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Insulin icodec
Insulin icodec
0 Images
Cat. No.: HY-P4070
CAS No.: 1188379-43-2
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .
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Crisugabalin
Crisugabalin
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Cat. No.: HY-142240
CAS No.: 2209104-84-5
Synonyms: HSK16149
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

Crisugabalin is an orally active, selective ligand for the α2δ subunit of voltage-gated calcium channels, with a target IC50 of 3.96 nM in rats. Crisugabalin inhibits the binding of [ 3H]gabapentin to the α2δ subunit, reduces calcium influx, decreases neuronal excitability, and impairs nociceptive transmission. Crisugabalin alleviates mechanical allodynia, neuropathic pain and inflammatory pain in rats, and reduces phase II pain behaviors. Crisugabalin can be used in research related to chronic pain, neuropathic pain, diabetic neuropathy, fibromyalgia, inflammatory pain, diabetic peripheral neuropathy and postherpetic neuralgia.
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4-Hydroxyindole
4-Hydroxyindole
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Cat. No.: HY-34596
CAS No.: 2380-94-1
Target:  

Biochemical Assay Reagents Amyloid-β

Research Areas:  

Neurological Disease Metabolic Disease

4-Hydroxyindole is a type of hydroxyindole in which the 1H-indole at position 4 is substituted by a hydroxyl group. 4-Hydroxyindole serves as an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. 4-Hydroxyindole inhibits amyloid fibrillization and induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice. 4-Hydroxyindole holds potential for research in neurodegenerative diseases and metabolic disorders .
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Acetamide
Acetamide
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Cat. No.: HY-Y0946
CAS No.: 60-35-5
Category:  

Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

Environmental Pollutants

Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies .
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