3037549-86-0
Chemical Structure
CBPD-409
- CAS No.: 3037549-86-0
- Formula:C46H52F2N10O5
- Molecular Weight:862.97
InChIKey: CXJGNQXWKVPWMM-KEQSSBIPSA-N
SMILES: O=C(N1C2C(NC(CC2)=O)=O)C3=CC(N4CCN(C[C@@H]5CC[C@@H](N6C7=C(CN(C(C)=O)CC7)C(N8C9=C(CCC8)C=C(C(C(F)F)=C9)C%10=CN(C)N=C%10)=N6)CC5)CC4)=CC=C3C1=O
Biological Activity: CBPD-409 is an orally active PROTAC degrader for CBP/p300, with DC50 of 0.2-0.4 nM. CBPD-409 exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP and 22Rv1, with IC50s of 1.2-2.0 nM. CBPD-409 exhibits antitumor efficacy (Red: CBP inhibitor GNE049 (HY-108435); Blue: CRBN/cullin 4A Thalidomide (HY-14658); Black: Linker)[1].
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CBPD-409 | 98.84% | CBPD-409 is an orally active PROTAC degrader for CBP/p300, with DC50 of 0.2-0.4 nM. CBPD-409 exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP and 22Rv1, with IC50s of 1.2-2.0 nM. CBPD-409 exhibits antitumor efficacy (Red: CBP inhibitor GNE049 (HY-108435); Blue: CRBN/cullin 4A Thalidomide (HY-14658); Black: Linker). | ||||||||||||||||||||
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-
Similarity Score 0.87
HY-161369CBPD-268 -
Similarity Score 0.77
HY-139707PROTAC CBP/P300 Degrader-3 -
Similarity Score 0.75
HY-138536PROTAC CBP/P300 Degrader-1 -
Similarity Score 0.73
HY-134582dCBP-1 -
Similarity Score 0.69
HY-185786CBP/p300-IN-25 -
Similarity Score 0.66
HY-187066trans-CBP/p300 ligand 3-cyclohexane-CHO -
Similarity Score 0.65
HY-177927CBP-IN-1 acid -
Similarity Score 0.63
HY-153948CBP-IN-1 -
Similarity Score 0.63
HY-108435GNE-049 -
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