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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
IGF-1 receptor kinase
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "IGF-1 receptor kinase" in MCE Product Catalog:
7
7 Publications Verification
Target:
Research Areas:
GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), with IC50s of 27 and 25 nM, respectively. GSK1904529A shows poor activity (IC50>1 μM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity .
6
6 Cited Publications
Target:
Research Areas:
BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity .
3
3 Cited Publications
Synonyms: ADW742; GSK 552602A; ADW
Target:
Research Areas:
NVP-ADW742 (ADW742) is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells .
2
2 Cited Publications
Cat. No.: HY-P78723
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IGF1R; IGF-I receptor; Insulin Like Growth Factor 1 receptor; MGC18216; Insulin-Like Growth Factor 1 receptor; Insulin-Like Growth Factor I receptor; JTK13; receptor Protein-Tyrosine kinase; CD221; Tyrosine-Protein kinase receptor; IGFIR; CD221 Antigen; IGFR; IGF1R Protein
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Synonyms: I-OMe-AG 538
Target:
Research Areas:
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM .
Target:
Cat. No.: HY-E70730
Target:
Research Areas:
The whole IGF axis constitutes an interactive network composed of the peptide-ligands IGF1, IGF2 and insulin, and the receptors IGF1R, IGF2R and insulin receptor (INSR) as IGF binding proteins (IGFBPs). The INSR itself appears in two isoforms, INSRA and INSRB differing in 12 amino acids encoded by exon 11. INSR Recombinant Human Active Protein Kinase is a recombinant INSR protein that can be used to study INSR-related functions .
Cat. No.: HY-162506
CAS No.: 1227753-12-9
IGF-1R inhibitor-3 (Compound C11) is an allosteric inhibitor for insulin-like growth factor receptor 1 kinase (IGF-1R), with an IC50 of 0.2 μM .
Cat. No.: HY-118046
CAS No.: 1123163-20-1
Research Areas:
GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272).
Cat. No.: HY-10252A
CAS No.: 475489-15-7
Synonyms: cis-ADW742; cis-GSK 552602A; cis-ADW
Target:
Research Areas:
cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742 (HY-10252). NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells .
Cat. No.: HY-125102
CAS No.: 851432-37-6
AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity.
Cat. No.: HY-10262R
CAS No.: 468740-43-4
Research Areas:
BMS-536924 (Standard) is the analytical standard of BMS-536924 (HY-10262). This product is intended for research and analytical applications. BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity .
Cat. No.: HY-P72256
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IGF1R; IGF-I receptor; Insulin Like Growth Factor 1 receptor; MGC18216; Insulin-Like Growth Factor 1 receptor; Insulin-Like Growth Factor I receptor; JTK13; receptor Protein-Tyrosine kinase; CD221; Tyrosine-Protein kinase receptor; IGFIR; CD221 Antigen; I
Species:
Human
Source:
E. coli
Cat. No.: HY-P72606
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1R; IGF-I receptor; Insulin Like Growth Factor 1 receptor; MGC18216; Insulin-Like Growth Factor 1 receptor; Insulin-Like Growth Factor I receptor; JTK13; receptor Protein-Tyrosine kinase; CD221; Tyrosine-Protein kinase receptor; IGFIR; CD221 Antigen; I
Species:
Human
Source:
HEK293
Cat. No.: HY-P74442
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1R; IGF-I receptor; Insulin Like Growth Factor 1 receptor; MGC18216; Insulin-Like Growth Factor 1 receptor; Insulin-Like Growth Factor I receptor; JTK13; receptor Protein-Tyrosine kinase; CD221; Tyrosine-Protein kinase receptor; IGFIR; CD221 Antigen; I
Species:
Human
Source:
HEK293
Cat. No.: HY-P78458
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IGF1R; IGF-I receptor; Insulin Like Growth Factor 1 receptor; MGC18216; Insulin-Like Growth Factor 1 receptor; Insulin-Like Growth Factor I receptor; JTK13; receptor Protein-Tyrosine kinase; CD221; Tyrosine-Protein kinase receptor; IGFIR; CD221 Antigen; I
Species:
Human
Source:
HEK293
Cat. No.: HY-P704676
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1R; IGF-I receptor; Insulin Like Growth Factor 1 receptor; MGC18216; Insulin-Like Growth Factor 1 receptor; Insulin-Like Growth Factor I receptor; JTK13; receptor Protein-Tyrosine kinase; CD221; Tyrosine-Protein kinase receptor; IGFIR; CD221 Antigen; I
Species:
Human
Source:
HEK293
Cat. No.: HY-P78142
Purity: ≥ 90%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: IGF1R; IGF-I receptor; Insulin Like Growth Factor 1 receptor; MGC18216; Insulin-Like Growth Factor 1 receptor; Insulin-Like Growth Factor I receptor; JTK13; receptor Protein-Tyrosine kinase; CD221; Tyrosine-Protein kinase receptor; IGFIR; CD221 Antigen; I
Species:
Human
Source:
HEK293
Cat. No.: HY-P73137
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: IGF1R; IGF-I receptor; Insulin Like Growth Factor 1 receptor; MGC18216; Insulin-Like Growth Factor 1 receptor; Insulin-Like Growth Factor I receptor; JTK13; receptor Protein-Tyrosine kinase; CD221; Tyrosine-Protein kinase receptor; IGFIR; CD221 Antigen; I
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
