468740-43-4
468740-43-4
Chemical Structure
BMS-536924
- CAS No.: 468740-43-4
- Formula:C25H26ClN5O3
- Molecular Weight:479.96
IUPAC Name: (S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(7-methyl-5-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
InChIKey: ZWVZORIKUNOTCS-OAQYLSRUSA-N
SMILES: O=C1C(C2=NC3=CC(N4CCOCC4)=CC(C)=C3N2)=C(C=CN1)NC[C@@H](O)C5=CC=CC(Cl)=C5
Biological Activity: BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity[1][2].
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BMS-536924 | 99.83% | BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity. | ||||||||||||||||||||
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BMS-536924 (Standard) | ≥98% | BMS-536924 (Standard) is the analytical standard of BMS-536924 (HY-10262). This product is intended for research and analytical applications. BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity. | ||||||||||||||||||||
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References
- [1]. Wittman M, et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem. 2005 Sep 8;48(18):5639-43. [Content Brief]
- [2]. Litzenburger BC, et al. BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells. Clin Cancer Res. 2009 Jan 1;15(1):226-37. [Content Brief]
