2 Results for "

ITM 077

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "ITM 077" in MCE Product Catalog:

Cat. No.: HY-P0165
CAS No.: 275371-94-3
Synonyms: ITM077; R1583; BIM51077
Target:  

GCGR

Research Areas:  

Metabolic Disease

Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist developed for treatment of type 2 diabetes, with an EC50 value of 0.06 nM.
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Cat. No.: HY-P0165B
CAS No.: 1022150-16-8
Synonyms: ITM077 acetate; R1583 acetate; BIM51077 acetate
Target:  

GLP Receptor

Research Areas:  

Metabolic Disease

Taspoglutide (R1583) acetate is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) with an Ki value of 1.1 nM. Taspoglutide acetate induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide acetate decreases blood levels of glucose and increases blood levels of insulin in a glucose tolerance test in Zucker diabetic obese rats. Taspoglutide acetate reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model .
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