15 Results for "

Ighe

" in MedChemExpress (MCE) Product Catalog:
Products (15)

15 Results for "Ighe" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99300
CAS No.: 1322627-61-1
Synonyms: QGE 031; Anti-Ighe Recombinant Antibody

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

Ligelizumab (QGE 031) is a humanized high-affinity anti-immunoglobulin IgE monoclonal antibody. Ligelizumab selectively inhibits the binding of IgE to the high-affinity receptor FcεRI, while the inhibitory effect on the low-affinity receptor CD23 is weak. Ligelizumab can inhibit the activation of effector cells such as mast cells and Basophil, while reducing the production of IgE by B cells, and restoring the IFN-α production and regulatory T cell (Treg) induction function of plasmacytoid dendritic cells (pDC). Ligelizumab can be used in the study of allergic diseases (such as chronic spontaneous urticaria, allergic asthma) .
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1
1 Cited Publications
Cat. No.: HY-P77695
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ighe; Ig Epsilon Chain C Region; Immunoglobulin Heavy Constant Epsilon; Immunoglobulin Epsilon; Constant Region Of Heavy Chain Of IgE; IgE; Ig Epsilon Chain C Region ND
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P99313
CAS No.: 1228538-47-3
Synonyms: Anti-Human Ighe Recombinant Antibody; 47H4; MEMP1972A
Quilizumab (Anti-Human IGHE Recombinant Antibody; 47H4; MEMP1972A) is a monoclonal antibody that targets FcγRIIIa and the M1 prime segment of human membrane-bound IgE. Quilizumab has enhanced FcγRIIIa binding affinity and activity against IgE class-switched B cells, and reduces serum IgE levels by inducing antibody-dependent cell-mediated cytotoxicity and apoptosis through cross-linking of membrane-bound IgE receptors. Quilizumab depletes IgE-producing cells; it also directly binds the membrane-bound M1 prime domain on IgE class-switched cells to inhibit IgE production. Quilizumab is used in research on allergic asthma and allergic diseases (asthma, allergic rhinitis) .
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Cat. No.: HY-P991252
Synonyms: AIMab-7195

Target:  

Histamine Receptor

Research Areas:  

Inflammation/Immunology

XmAb-7195 (AIMab-7195) is a human monoclonal antibody (mAb) targeting IGHE. XmAb-7195 can be used in Food hypersensitivity, Allergic asthma, Allergic rhinitis, Atopic dermatitis and Conjunctivitis research .
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Cat. No.: HY-P990936
CAS No.: 2823332-50-7
Synonyms: JYB-1904; RPT904

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

HY-P990936 is an IGHE-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P991256

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

FB-825 is a human monoclonal antibody (mAb) targeting IGHE. FB-825 targets the CεmX domain of membrane IgE (mIgE), resulting in the downregulation of mIgE-positive B cells and the production of IgE. FB-825 can be used in Allergic asthma, Atopic dermatitis, Job syndrome and Allergic rhinitis research .
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Cat. No.: HY-RS19398
Research Areas:  

Others

Ighe Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ighe gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS16358
Research Areas:  

Others

IGHE Human Pre-designed siRNA Set A contains three designed siRNAs for IGHE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P73907
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ighe; Ig Epsilon Chain C Region; Immunoglobulin Heavy Constant Epsilon; Immunoglobulin Epsilon; Constant Region Of Heavy Chain Of IgE; IgE; Ig Epsilon Chain C Region ND
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P77694
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Ighe; Ig Epsilon Chain C Region; Immunoglobulin Heavy Constant Epsilon; Immunoglobulin Epsilon; Constant Region Of Heavy Chain Of IgE; IgE; Ig Epsilon Chain C Region ND
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P77696
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Ighe; Ig Epsilon Chain C Region; Immunoglobulin Heavy Constant Epsilon; Immunoglobulin Epsilon; Constant Region Of Heavy Chain Of IgE; IgE; Ig Epsilon Chain C Region ND
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P700736
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ighe; Ig Epsilon Chain C Region; Immunoglobulin Heavy Constant Epsilon; Immunoglobulin Epsilon; Constant Region Of Heavy Chain Of IgE; IgE; Ig Epsilon Chain C Region ND
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P705217
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ighe; Ig Epsilon Chain C Region; Immunoglobulin Heavy Constant Epsilon; Immunoglobulin Epsilon; Constant Region Of Heavy Chain Of IgE; IgE; Ig Epsilon Chain C Region ND
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P704670
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Ighe; Ig Epsilon Chain C Region; Immunoglobulin Heavy Constant Epsilon; Immunoglobulin Epsilon; Constant Region Of Heavy Chain Of IgE; IgE; Ig Epsilon Chain C Region ND
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P704671
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ighe; Ig Epsilon Chain C Region; Immunoglobulin Heavy Constant Epsilon; Immunoglobulin Epsilon; Constant Region Of Heavy Chain Of IgE; IgE; Ig Epsilon Chain C Region ND
Species:  
Human
Source:  
HEK293
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