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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Large Tumor Suppressor (LATS)
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Large Tumor Suppressor (LATS)" in MCE Product Catalog:
7
7 Publications Verification
Target:
Research Areas:
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids .
2
2 Cited Publications
Cat. No.: HY-P81210
Synonyms: LATS1 +LATS2 (phospho T1079 + T1041); Serine/threonine protein kinase LATS2; KPM; Large Tumor supressor, homolog 1; LATS, Large Tumor Suppressor, homolog 1 (Drosophila); LATS, Large Tumor Suppressor, homolog 2 (Drosophila); LATS1 +LATS2 (phospho T1079 + T1041); p-LATS1 +LATS2(Thr1079 +Thr1041); RGD1564085; Serine/threonine protein kinase LATS1; WARTS; WARTS protein kinase; wts; 4932411G09Rik; AV277261; AW208599; AW228608; FLJ13161; LATS1_HUMAN.
1
Cat. No.: HY-176886
CAS No.: 2248728-49-4
Target:
Research Areas:
LATS-IN-2 is an efficiently acting LATS (large tumor suppressor kinase) inhibitor. LATS-IN-2 shows potent inhibitory activity against LATS1 with an IC50 value of 1.3 nM. LATS-IN-2 suppresses the phosphorylation of YAP by inhibiting LATS kinase activity. LATS-IN-2 increases the thickness of the epidermis in mice. LATS-IN-2 can be used for the study of ocular diseases such as limbal stem cell deficiency and corneal endothelial dysfunction .
Cat. No.: HY-P704000
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: LATS1; WARTS Protein Kinase; Large Tumor Suppressor Kinase 1; H-Warts; WARTS; LATS, Large Tumor Suppressor, Homolog 1 (Drosophila); LATS (Large Tumor Suppressor, Drosophila) Homolog 1; LATS, Large Tumor Suppressor, Homolog 1; Serine/Threonine-Protein Kina
Species:
Human
Source:
E. coli
Cat. No.: HY-P703258
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LATS1; WARTS Protein Kinase; Large Tumor Suppressor Kinase 1; H-Warts; WARTS; LATS, Large Tumor Suppressor, Homolog 1 (Drosophila); LATS (Large Tumor Suppressor, Drosophila) Homolog 1; LATS, Large Tumor Suppressor, Homolog 1; Serine/Threonine-Protein Kina
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705846
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LATS2; Large Tumor Suppressor Homolog 2; Large Tumor Suppressor Kinase 2; Warts-Like Kinase; LATS (Large Tumor Suppressor, Drosophila) Homolog 2; KPM; Kinase Phosphorylated During Mitosis Protein; LATS, Large Tumor Suppressor, Homolog 2 (Drosophila); Seri
Species:
Human
Source:
sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
