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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
MC-AcLys-GDEVD-PABC-Exatecan
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "MC-AcLys-GDEVD-PABC-Exatecan" in MCE Product Catalog:
Cat. No.: HY-185101
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MC-AcLys-GDEVD-PABC-Exatecan (MC-AcLys-GDEVD-PABC-DX8951) is a agent-linker conjugate for ADC. MC-AcLys-GDEVD-PABC-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with a novel caspase-3 cleavable peptide linker MC-AcLys-GDEVD-PABC linker. MC-AcLys-GDEVD-PABC-Exatecan can be used to prepare DX8951 antibody conjugate (ADC), and it exhibites significant bystander effect mediated by the caspase-3-triggered extracellular cleavage of the linker, enhancing payload release into the tumor microenvironment.
50
50 Publications Verification
Cat. No.: HY-P1001
CAS No.: 169332-60-9
13
13 Cited Publications
Cat. No.: HY-P1005
CAS No.: 201608-14-2
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5
5 Cited Publications
Cat. No.: HY-P1003
CAS No.: 169332-61-0
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1
1 Cited Publications
Cat. No.: HY-P1006
CAS No.: 189950-66-1
Cat. No.: HY-P5830
CAS No.: 178603-73-1
Cat. No.: HY-P5830A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
