79 Results for "

Melanogenesis

" in MedChemExpress (MCE) Product Catalog:
Products (79)

79 Results for "Melanogenesis" in MCE Product Catalog:

6
N-Acetylneuraminic acid
N-Acetylneuraminic acid
0 Images
6 Publications Verification
Cat. No.: HY-I0400
CAS No.: 131-48-6
Synonyms: NANA; Lactaminic acid
Category:  

Cardiovascular Disease Microorganisms Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:  

Tyrosinase Ras Influenza Virus Endogenous Metabolite

N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .
loading...
    loading...
View All Sizes
2
Nonapeptide-1
Nonapeptide-1
0 Images
2 Cited Publications
Cat. No.: HY-P0097
CAS No.: 158563-45-2
Synonyms: Melanostatine-5
Target:  

Melanocortin Receptor

Research Areas:  

Metabolic Disease Endocrinology Cancer

Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .
loading...
    loading...
View All Sizes
2
Tribuloside
Tribuloside
0 Images
2 Cited Publications
Cat. No.: HY-N2443
CAS No.: 22153-44-2
Category:  

Tribulus terrester Linn. Flavonols Flavonoids Zygophyllaceae Phenols Polyphenols Plants

Target:  

Free Radical Scavengers Phosphodiesterase (PDE) Bacterial PKA Tyrosinase TRP Channel Microphthalmia Associated Transcription Factor (MITF) Interleukin Related

Tribuloside is a flavonoid and PDE4 inhibitor (IC50: 6 μM). Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging DPPH free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury .
loading...
    loading...
View All Sizes
2
Nonapeptide-1 acetate salt
Nonapeptide-1 acetate salt
0 Images
2 Cited Publications
Cat. No.: HY-P0097A
Synonyms: Melanostatine-5 acetate salt
Target:  

Melanocortin Receptor

Research Areas:  

Metabolic Disease Endocrinology Cancer

Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .
loading...
    loading...
View All Sizes
1
Methyl linolenate
Methyl linolenate
0 Images
1 Cited Publications
Cat. No.: HY-21268
CAS No.: 301-00-8
Synonyms: Linolenic acid methyl ester
Category:  

other families Other Diseases Lipids Plants Disease Research Fields

Target:  

Environmental Pollutants Melatonin Receptor

Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC50 of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .
loading...
    loading...
View All Sizes
1
Raspberry ketone glucoside
Raspberry ketone glucoside
0 Images
1 Cited Publications
Cat. No.: HY-N6069
CAS No.: 38963-94-9
Category:  

Ketones, Aldehydes, Acids Rosaceae Plants Rubus corchorifolius Linn. f. Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related JAK STAT

Raspberry ketone glucoside is a melanogenesis inhibitor. Raspberry ketone glucoside inhibits melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes. Raspberry ketone glucoside shows remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo .
loading...
    loading...
View All Sizes
1
Hordenine
Hordenine
0 Images
1 Cited Publications
Cat. No.: HY-N0113
CAS No.: 539-15-1
Synonyms: Ordenina; Peyocactine
Category:  

Cardiovascular Disease Alkaloids other families Monophenols Other Alkaloids Phenols Plants Disease Research Fields

Target:  

Bacterial Antibiotic

Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .
loading...
    loading...
View All Sizes
1
Retusin
Retusin
0 Images
1 Cited Publications
Cat. No.: HY-N6829
CAS No.: 1245-15-4
Synonyms: Quercetin-​3,​3',​4',​7-​tetramethylether
Category:  

Flavonols Flavonoids Monophenols Entada phaseoloides (L.) Merr. Labiatae Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase Fungal SARS-CoV Apoptosis Reactive Oxygen Species (ROS)

Retusin (Quercetin-3,3',4',7-tetramethylether) is a tyrosinase inhibitor, with IC50 values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS• + and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection .
loading...
    loading...
View All Sizes
1
Hordenine hydrochloride
Hordenine hydrochloride
0 Images
1 Cited Publications
Cat. No.: HY-N0113B
CAS No.: 6027-23-2
Synonyms: Ordenina hydrochloride; Peyocactine hydrochloride
Category:  

Coryphantha vivipara var arizonica Alkaloids Monophenols Cactaceae Other Alkaloids Phenols Plants

Target:  

Bacterial

Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .
loading...
    loading...
View All Sizes
Orcinol
Orcinol
0 Images
Cat. No.: HY-D0168
CAS No.: 504-15-4
Synonyms: 3,5-Dihydroxytoluene
Category:  

Microorganisms Other Diseases Phenols Polyphenols Plants Ericaceae Disease Research Fields

Target:  

Fluorescent Dye Free Radical Scavengers Tyrosinase p38 MAPK ERK

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .
loading...
    loading...
View All Sizes
Gomisin N
Gomisin N
0 Images
Cat. No.: HY-N6866
CAS No.: 69176-52-9
Category:  

Neurological Disease Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Apoptosis AMPK Akt PERK Keap1-Nrf2 Caspase PARP GSK-3 NO Synthase Interleukin Related

Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease .
loading...
    loading...
View All Sizes
Ethyl linolenate
Ethyl linolenate
0 Images
Cat. No.: HY-N2073
CAS No.: 1191-41-9
Category:  

Cardiovascular Disease other families Lipids Plants Disease Research Fields

Target:  

MCHR1 (GPR24)

Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects .
loading...
    loading...
View All Sizes
Swertiajaponin
Swertiajaponin
0 Images
Cat. No.: HY-N2204
CAS No.: 6980-25-2
Category:  

other families Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase Reactive Oxygen Species (ROS)

Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .
loading...
    loading...
View All Sizes
3',4'-Dihydroxyacetophenone
3',4'-Dihydroxyacetophenone
0 Images
Cat. No.: HY-N1775
CAS No.: 1197-09-7
Synonyms: 3,4-DHAP
Category:  

Pinaceae Phenols Polyphenols Plants Picea schrenkiana Fisch. et Mey. Disease Research Fields Cancer

Target:  

Tyrosinase Reactive Oxygen Species (ROS) Keap1-Nrf2 PARP Autophagy Apoptosis

3',4'-Dihydroxyacetophenone (3,4-DHAP) is a phenolic compound with oral bioavailability, possessing potent antioxidant, anti-inflammatory, anticancer and cardiovascular protective activities. 3',4'-Dihydroxyacetophenone inhibits mushroom Tyrosinase activity with an IC50 of 10 μM, thereby suppressing melanogenesis . 3',4'-Dihydroxyacetophenone inhibits platelet aggregation in platelet-rich plasma. 3',4'-Dihydroxyacetophenone reduces ROS levels in human umbilical vein endothelial cells treated with high glucose, upregulates the expression of Nrf2, HO-1 and PARP-1 in cells, and promotes the nuclear translocation of Nrf2 . 3',4'-Dihydroxyacetophenone induces autophagy and apoptosis. 3',4'-Dihydroxyacetophenone inhibits seed germination/growth in most plants. 3',4'-Dihydroxyacetophenone can be used in the research of cancer, neurodegenerative diseases, non-alcoholic steatohepatitis, diabetes, obesity, skin pigmentation disorders, and cardiovascular and cerebrovascular diseases .
loading...
    loading...
View All Sizes
Terrein
Terrein
0 Images
Cat. No.: HY-119808
CAS No.: 582-46-7
Target:  

Melanocortin Receptor Apoptosis Antibiotic

Research Areas:  

Cancer

Terrein is a melanogenesis inhibitor . Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa .
loading...
    loading...
View All Sizes
(-)-Isodocarpin
(-)-Isodocarpin
0 Images
Cat. No.: HY-134046
CAS No.: 10391-08-9
Synonyms: Isodocarpin
Category:  

Labiatae Erythrina sacleuxii Hua Plants

Target:  

Melanocortin Receptor

(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA .
loading...
    loading...
View All Sizes
Velutin
Velutin
0 Images
Cat. No.: HY-N1098
CAS No.: 25739-41-7
Category:  

other families Flavonoids Microorganisms Flavones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase p38 MAPK NF-κB Bacterial

Velutin is a flavonoid. Velutin can be extracted from mistletoe. Velutin inhibits mushroom Tyrosinase activity with an IC50 of 910.1 μM. Velutin inhibits p38 phosphorylation, the NF-κB pathway and the MAPK pathway. Velutin prevents articular cartilage degeneration and subchondral bone loss. Velutin slows down the progression of intervertebral disc degeneration. Velutin exhibits inhibitory effects on melanogenesis, skin whitening, anti-inflammatory, anti-allergic, anti-oxidant and antibacterial activities. Velutin can be used in studies related to pigmented diseases, osteoarthritis and intervertebral disc degeneration .
loading...
    loading...
View All Sizes
Ganodermanondiol
Ganodermanondiol
0 Images
Cat. No.: HY-N2996
CAS No.: 107900-76-5
Category:  

Infection Triterpenes Microorganisms Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields

Target:  

HIV Protease

Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC50 of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC50 of 41.7μM .
loading...
    loading...
View All Sizes
Geranic acid
Geranic acid
0 Images
Cat. No.: HY-W115529
CAS No.: 459-80-3
Synonyms: Geranate; NSC 229335; GAGE
Category:  

Ketones, Aldehydes, Acids Plants Lauraceae  Litsea cubeba (Lour.) Pers.

Target:  

Environmental Pollutants Fungal Tyrosinase

Geranic acid (Geranate) acts as a tyrosinase inhibitor and antifungal agent, with an IC50 value of 0.14-2.3 mM against mushroom tyrosinase. Geranic acid reduces the viability of human pancreatic cancer cells and B-lymphoma cells. Geranic acid inhibits mycelial growth of the maize pathogens Colletotrichum graminicola and Fusarium graminearum. Geranic acid is applicable to research related to fungal infections, pancreatic cancer and B-lymphoma .
loading...
    loading...
View All Sizes
Cubebin
Cubebin
0 Images
Cat. No.: HY-N10423
CAS No.: 18423-69-3
Synonyms: (-)-Cubebin
Category:  

Lignans Piperaceae Piper cubeba L.f. Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Cholinesterase (ChE) Bacterial Fungal Parasite p38 MAPK

Cubebin ((-)-Cubebin), a dibenzyl butyrolactone lignan, is an orally active AChE inhibitor. Cubebin binds to active sites of NF-κB, TNF-α, and TGF-β1 via hydrogen and hydrophobic interactions, obstructing critical residues to inhibit pro-inflammatory or renal fibrosis-related activity. Cubebin enhances p38 MAPK phosphorylation to increase tyrosinase gene expression, stimulating melanogenesis via elevated tyrosinase activity, expression, and mRNA levels. Cubebin reduces oxidative stress via enhanced endogenous antioxidant enzyme activity and inhibited lipid peroxidation, regulates lipid metabolism, improves glycemic control, and exerts renoprotective effects via reduced renal dysfunction markers and improved renal architecture. Cubebin shows antimicrobial activity. Cubebin exerts larvicidal activity against Angiostrongylus cantonensis larvae, with no cytotoxicity toward monkey or human cell lines or Caenorhabditis elegans. Cubebin can be used for the research of diabetic nephropathy, melanoma, colon adenocarcinoma, neuroangiostrongyliasis, Alzheimer’s disease (AD) and depression .
loading...
    loading...
View All Sizes
Assay Types