(-)-Isodocarpin
Based on 1 Customer Validation
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA.
For research use only. We do not sell to patients.
- Purity : 99.78%
- CAS No.: 10391-08-9
- Formula: C20H26O5
- Molecular Weight:346.42
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.2 μM
Compound: 14
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Cytotoxicity against human A549 cells after 48 hrs by MTS assay
Cytotoxicity against human A549 cells after 48 hrs by MTS assay
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[PMID: 24219809] |
| HL-60 | IC50 |
2.8 μM
Compound: 14
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Cytotoxicity against human HL60 cells after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells after 48 hrs by MTS assay
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[PMID: 24219809] |
| MCF7 | IC50 |
2.6 μM
Compound: 14
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Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
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[PMID: 24219809] |
| RAW264.7 | IC50 |
2.2 μM
Compound: 14
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Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay
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[PMID: 24219809] |
| SMMC-7721 | IC50 |
3.5 μM
Compound: 14
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Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay
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[PMID: 24219809] |
| SW480 | IC50 |
1 μM
Compound: 14
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Cytotoxicity against human SW480 cells after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells after 48 hrs by MTS assay
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[PMID: 24219809] |
Chemical Information
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CAS No. 10391-08-9
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Appearance Solid
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Molecular Weight 346.42
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Formula C20H26O5
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Color White to off-white
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SMILES
O[C@H]1[C@@]2([H])[C@]3(CO1)[C@@]4([H])[C@@]5(C(O[C@@]3([H])CCC2(C)C)=O)C[C@@](C(C5=O)=C)([H])CC4
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Synonyms
Isodocarpin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Protocols
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-Isodocarpin Related Classifications
HY-134046 Related Classifications
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