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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Methionine aminopeptidase-2
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Methionine aminopeptidase-2" in MCE Product Catalog:
2
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TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.
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1 Cited Publications
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TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM against MetAP2. TP-004 is a chemical probe. TP-004 suppresses MetAP2 enzymatic activity, blocks N-terminal methionine cleavage, impairs protein maturation and stability, and thereby inhibits cell proliferation and angiogenesis. TP-004 can be used for the study of tumors and diseases associated with excessive angiogenesis .
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M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity .
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PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research .
Synonyms: ZGN-1061
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Aclimostat (ZGN-1061) is a methionine aminopeptidase 2 (MetAP2) inhibitor. Aclimostat exhibits anti-obesity, anti-diabetic and ovarian cancer-related activities, and does not readily distribute to the central nervous system. Aclimostat acts on the active site of MetAP2 via irreversible covalent binding, and blocks enzyme activity through interactions with His231 and His339. Aclimostat regulates gene expression, reduces fat mass, plasma glucose, insulin levels, LDL-C, hs-CRP and leptin levels, while increasing adiponectin levels. Aclimostat can be used in research related to type 2 diabetes, overweight, obesity and ovarian cancer .
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .
Cat. No.: HY-183876
CAS No.: 661482-39-9
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LAF-153 is a Methionine Aminopeptidase-2 (MetAP-2) inhibitor with human IC50 values of 0.074 μM and 0.16 μM.LAF-153 has a t-butyl group extending into the innermost portion of the MetAP-2 cleft, a lactam ring coordinated in the enzyme’s shallow surface pocket, and three hydroxyl groups coordinating to the two cobalt ions in the enzyme’s active site .
Cat. No.: HY-P70364
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: METAP2; MAP2; Methionyl aminopeptidase 2; MetAP 2; MNPEP; MAP 2; P67; Testicular Tissue Protein Li 17; Initiation Factor 2-Associated 67 KDa Glycoprotein; EIF-2-Associated P67 Homolog; Methionine aminopeptidase 2; Alternative Protein METAP2; Peptidase M;
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P75925
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: METAP2; MAP2; Methionyl aminopeptidase 2; MetAP 2; MNPEP; MAP 2; P67; Testicular Tissue Protein Li 17; Initiation Factor 2-Associated 67 KDa Glycoprotein; EIF-2-Associated P67 Homolog; Methionine aminopeptidase 2; Alternative Protein METAP2; Peptidase M;
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-182419
CAS No.: 904680-01-9
A-849519 is a reversible methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 19 nM. A-849519 binds to the active site of the Mn 2+ form of human MetAP-2, where the oxygen atom of one acidic functional group interacts with the manganese ion, and another heteroatom binds to the water molecule above the two manganese ions, thereby functionally inhibiting enzyme activity. A-849519 inhibits the methionine processing activity of MetAP-2 as well as the proliferation of fibrosarcoma cells. A-849519 can be used in studies related to fibrosarcoma .
Cat. No.: HY-P703925
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: METAP2; MAP2; Methionyl aminopeptidase 2; MetAP 2; MNPEP; MAP 2; P67; Testicular Tissue Protein Li 17; Initiation Factor 2-Associated 67 KDa Glycoprotein; EIF-2-Associated P67 Homolog; Methionine aminopeptidase 2; Alternative Protein METAP2; Peptidase M;
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-101932R
CAS No.: 129298-91-5
Synonyms: AGM-1470 (Standard)
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TNP-470 (Standard) is the analytical standard of TNP-470 (HY-101932). This product is intended for research and analytical applications. TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.
Cat. No.: HY-122225
CAS No.: 836671-12-6
JNJ-4929821 (Compound 88), a triazole derivative, is a selective Methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 15 nM over MetAP-1. JNJ-4929821 can be used for cancers like liver cancer, colorectal adenocarcinoma and pancreatic cancer research .
Cat. No.: HY-181644
CAS No.: 3075693-63-6
NS-181 is an orally active MetAP2 inhibitor and antiamebic agent with oral effectiveness.NS-181 functionally inhibits methionine aminopeptidase 2, a protein critical for Entamoeba histolytica proliferation. NS-181 exerts antiamebic activity against Entamoeba histolytica, leading to resolution of amebic liver abscess. NS-181 can be used for the research of amebiasis .
Cat. No.: HY-184384
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MetAP-2 modulator-1 is a MetAP-2 modulator. MetAP-2 modulator-1 reduces the MetAP-2 enzyme level in cells. MetAP-2 modulator-1 exhibits anticancer effects against neuroblastoma. MetAP-2 modulator-1 can be used in studies related to neuroblastoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
