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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
N-cadherin
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "N-cadherin" in MCE Product Catalog:
43
10
10
10 Cited Publications
3
3 Cited Publications
Synonyms: Antibiotic A 15104 Y; PClP
Target:
Research Areas:
Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β .
2
1
1 Cited Publications
Target:
Research Areas:
ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM .
1
1 Cited Publications
Cat. No.: HY-P73302
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDH2; N-cadherin; Prev. NCAD; Calcium-Dependent Adhesion Protein, Neuronal; CDHN; CD325 Antigen; Neural cadherin; N-cadherin 1; cadherin-2; ARVD14; CD325; ADHD8; cadherin 2, Type 1, N-cadherin (Neuronal); ACOGS; cadherin 2; CDw325
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P75667
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CDH12; cadherin 12, Type 2 (N-cadherin 2); cadherin 12; cadherin, Neural Type, 2; Br-cadherin; Neuronal cadherin 2; CDHB; Brain-cadherin; Neural Type cadherin 2; Brain cadherin; N-cadherin 2; BR-cadherin; cadherin-12
Species:
Human
Source:
HEK293
Cat. No.: HY-P11017
CAS No.: 1152066-26-6
Research Areas:
Cat. No.: HY-P11288
CAS No.: 2871680-36-1
Target:
Research Areas:
Cat. No.: HY-P11288A
Target:
Research Areas:
Cat. No.: HY-173557
CAS No.: 3058094-83-7
Target:
Research Areas:
PRMT7-IN-2 (A33) is a selective PRMT7 inhibitor with an IC50 of 0.50 μM. PRMT7-IN-2 arrests cell cycle at G0/G1 phase, induces cell apoptosis, and inhibits cell growth in vivo and in vitro. PRMT7-IN-2 decreases the monomethylarginine level of PRMT7, increases expression of epithelial marker (E-cadherin, and reduces expression of mesenchymal markers such as N-cadherin, Vimentin, and ZEB2 .
Cat. No.: HY-P11346
CAS No.: 1830290-52-2
Target:
Research Areas:
Cat. No.: HY-P5755
Target:
Research Areas:
Cat. No.: HY-19987A
CAS No.: 2095432-75-8
BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM .
Cat. No.: HY-163709
PROTAC FAK degrader 2 is an orally active PROTAC FAK degrader with a DC50 of 60.10 nM. PROTAC FAK degrader 2 forms a ternary complex with FAK and CRBN E3 ubiquitin ligase, driving proteasome-mediated degradation of total and phosphorylated FAK. PROTAC FAK degrader 2 inhibits phosphorylation of AKT and ERK, suppressing their downstream signaling pathways. PROTAC FAK degrader 2 reduces cancer cell viability, adhesion, migration, and invasion. PROTAC FAK degrader 2 exerts anti-tumor activity in HCT8/T tumor xenografts in mice. PROTAC FAK degrader 2 can be used for the research of breast cancer, colorectal cancer, lung cancer .
Cat. No.: HY-N15267
CAS No.: 64280-22-4
Cat. No.: HY-173560
SHP2 ATTEC degrader-1 is a SHP2 ATTEC degrader. SHP2 ATTEC degrader-1 has degradation rate of 83.31 at 1.0 μM for 24 h in the PANC-1 cell line. SHP2 ATTEC degrader-1 inhibits cell growth in vivo and in vitro. SHP2 ATTEC degrader-1 induces apoptosis and increases the expression of the epithelial marker ( E-cadherin)， and reduces the expression of interstitial markers (such as N-cadherin, Vimentin) (Pink: LC3 ligand (HY-174085); Black :linker HY-140468; Blue: SHP2 ligand (HY-174084) .
Cat. No.: HY-P73750
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDH2; N-cadherin; Prev. NCAD; Calcium-Dependent Adhesion Protein, Neuronal; CDHN; CD325 Antigen; Neural cadherin; N-cadherin 1; cadherin-2; ARVD14; CD325; ADHD8; cadherin 2, Type 1, N-cadherin (Neuronal); ACOGS; cadherin 2; CDw325
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P703737
Purity: ≥ 95%, as determined by reducing SDS-PAGE.;≥ 90%, as determined by HPLC.
Synonyms: CDH2; N-cadherin; Prev. NCAD; Calcium-Dependent Adhesion Protein, Neuronal; CDHN; CD325 Antigen; Neural cadherin; N-cadherin 1; cadherin-2; ARVD14; CD325; ADHD8; cadherin 2, Type 1, N-cadherin (Neuronal); ACOGS; cadherin 2; CDw325
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
