1152066-26-6
Chemical Structure
LNSMGQD
- CAS No.: 1152066-26-6
- Formula:C29H49N9O13S
- Molecular Weight:763.82
InChIKey: YEXFTPPTKFXYNK-DYKIIFRCSA-N
SMILES: O=C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Biological Activity: LNSMGQD is a cyclic peptide fragment derived from desmoglein 1 (amino acids 81-86), which mimics trans-interactions and acts as part of the tandem peptide binding interface of desmoglein 2. LNSMGQD not only binds to desmoglein 1 and 3, but also effectively inhibits their homophilic trans-interactions, while reducing the probability of homophilic or heterophilic binding between desmoglein 2 and Dsc2, N-cadherin and E-cadherin. LNSMGQD is applicable to the research on disease mechanisms such as Crohn's disease and pemphigus vulgaris[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LNSMGQD | 99.92% | LNSMGQD is a cyclic peptide fragment derived from desmoglein 1 (amino acids 81-86), which mimics trans-interactions and acts as part of the tandem peptide binding interface of desmoglein 2. LNSMGQD not only binds to desmoglein 1 and 3, but also effectively inhibits their homophilic trans-interactions, while reducing the probability of homophilic or heterophilic binding between desmoglein 2 and Dsc2, N-cadherin and E-cadherin. LNSMGQD is applicable to the research on disease mechanisms such as Crohn's disease and pemphigus vulgaris. | ||||||||||||||||||||
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References
- [1]. Spindler V, et al. Loss of Desmoglein 2 Contributes to the Pathogenesis of Crohn's Disease. Inflamm Bowel Dis. 2015;21(10):2349-2359. [Content Brief]
- [2]. Spindler V, et al. Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering. J Clin Invest. 2013;123(2):800-811. [Content Brief]
- [3]. Fuchs M, et al. Desmoglein 2 can undergo Ca2+-dependent interactions with both desmosomal and classical cadherins including E-cadherin and N-cadherin[J]. Biophysical journal, 2022, 121(7): 1322-1335.
