NF-κB p65 subunit nuclear

Pathways Recommended:	NF-κB Vitamin D Related/Nuclear Receptor

By Targets:	NF-κB (9) Apoptosis (4) COX (5) Endogenous Metabolite (4) Ferroptosis (4) Fungal (1) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (2) Keap1-Nrf2 (2) MEK (1) NO Synthase (1) Reference Standards (3)
By Research Areas:	Cancer (11) Infection (3) Inflammation/Immunology (8)

Targets Recommended: NF-κB SF3B1 Orphan Nuclear Receptor Nuclear Factor of activated T Cells (NFAT) Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0290

Mangiferin Maximum Cited Publications 16 Publications Verification	NF-κB Keap1-Nrf2 Apoptosis	Cancer
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the *NF-κB* subunits *p65* and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-N0001

(-)-Epicatechin 10+ Cited Publications (-)-Epicatechol; Epicatechin; epi-Catechin	COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-10496

SC75741 Maximum Cited Publications 32 Publications Verification	NF-κB Influenza Virus	Infection Cancer
SC75741 is a broad and efficient *NF-κB* inhibitor with an IC₅₀ of 200 nM for *p65* . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the *NF-κB* subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .

HY-N0001R

(-)-Epicatechin (Standard) 10+ Cited Publications (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard)	Reference Standards COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-P1832A

PTD-p65-P1 Peptide TFA 3 Publications Verification	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-N0290R

Mangiferin (Standard)	Reference Standards NF-κB Keap1-Nrf2 Apoptosis	Cancer
Mangiferin (Standard) is the analytical standard of Mangiferin. This product is intended for research and analytical applications. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-N0811

Anemarsaponin B	NO Synthase COX NF-κB MEK	Inflammation/Immunology
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of *NF-κB* by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-P1832

PTD-p65-P1 Peptide	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-N0001S2

(-)-Epicatechin-13C3 (-)-Epicatechol-¹³C₃; Epicatechin-¹³C₃; epi-Catechin-¹³C₃	Isotope-Labeled Compounds Ferroptosis Endogenous Metabolite COX	Inflammation/Immunology Cancer
(-)-Epicatechin- ¹³C₃ ((-)-Epicatechol- ¹³C₃) is ¹³C labeled (-)-Epicatechin. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N0001S

(±)-Epicatechin-13C3	Isotope-Labeled Compounds COX Endogenous Metabolite Ferroptosis	Inflammation/Immunology Cancer
(±)-Epicatechin- ¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB .

HY-123461

Sul-121 hydrochloride	NF-κB	Inflammation/Immunology
Sul-121 hydrochloride is a novel compound with anti-oxidative capacity that effectively inhibits airway inflammation and hyperresponsiveness (AHR) in experimental models of chronic obstructive pulmonary disease (COPD). Sul-121 hydrochloride prevents lipopolysaccharide-induced airway neutrophilia and AHR in a dose-dependent manner. Sul-121 hydrochloride also demonstrates the ability to reduce oxidative stress markers in human airway smooth muscle cells. Sul-121 hydrochloride inhibits nuclear translocation of the NF-κB subunit, p65, thereby diminishing pro-inflammatory cytokine release.

HY-10496R

SC75741 (Standard)	Reference Standards NF-κB Influenza Virus	Infection Cancer
SC75741 (Standard) is the analytical standard of SC75741 (HY-10496). This product is intended for research and analytical applications. SC75741 is a broad and efficient NF-κB inhibitor with an IC₅₀ of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .

HY-N19791

6-Methoxymellein	NF-κB Fungal Interleukin Related	Infection Cancer
6-Methoxymellein, a phytoalexin, is a *NF-κB* inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44 ⁺/CD24 ⁻ breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot .

Cat. No.	Product Name	Target	Research Area

HY-P1832A

PTD-p65-P1 Peptide TFA 3 Publications Verification	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-P1832

PTD-p65-P1 Peptide	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0290

Mangiferin Maximum Cited Publications 16 Publications Verification	Liliaceae Xanthones Classification of Application Fields Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields Source Classification Cancer	NF-κB Keap1-Nrf2 Apoptosis
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the *NF-κB* subunits *p65* and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-N0001

(-)-Epicatechin 10+ Cited Publications (-)-Epicatechol; Epicatechin; epi-Catechin	Classification of Application Fields Anti-aging Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Flavonoids Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification Theaceae Cancer	COX Ferroptosis Endogenous Metabolite
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N0001R

(-)-Epicatechin (Standard) 10+ Cited Publications (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard)	Classification of Application Fields Anti-aging Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Flavonoids Sunscreen Phenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification Theaceae Cancer	Reference Standards COX Ferroptosis Endogenous Metabolite
(-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N0290R

Mangiferin (Standard)	Structural Classification Liliaceae Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Source Classification	Reference Standards NF-κB Keap1-Nrf2 Apoptosis
Mangiferin (Standard) is the analytical standard of Mangiferin. This product is intended for research and analytical applications. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-N0811

Anemarsaponin B	Liliaceae Classification of Application Fields Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	NO Synthase COX NF-κB MEK
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of *NF-κB* by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-N19791

6-Methoxymellein	Structural Classification Monophenols Coumarins Phenols Phenylpropanoids Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Source Classification	NF-κB Fungal Interleukin Related
6-Methoxymellein, a phytoalexin, is a *NF-κB* inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44 ⁺/CD24 ⁻ breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot .

Cat. No.	Product Name	Chemical Structure

HY-N0001S2

(-)-Epicatechin-13C3
(-)-Epicatechin- ¹³C₃ ((-)-Epicatechol- ¹³C₃) is ¹³C labeled (-)-Epicatechin. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N0001S

(±)-Epicatechin-13C3
(±)-Epicatechin- ¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB .

Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Rat (5) Mouse (5) Monkey (1)
Application:	IHC-P (5) ICC/IF (4) IF-Tissue (1) IP (2) IHC-F (3) WB (5) ELISA (2)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Polyclonal (1) Monoclonal (3)
Modification:	Phosphorylated (1) Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86492

	NF-κB p65 Antibody (YA6184) RELA; NFKB3; Transcription factor p65; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NF-κB p65 Antibody (YA6184) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-κB p65.

HY-P86720

	NF-KB p65 Antibody (YA6412) TF65_HUMAN; Transcription factor p65; RELA; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; RELA proto-oncogene, NF-kB subunit; p65; CMCU; NFKB3; AIF3BL3; NF-kB p65/RelA; NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	NF-KB p65 Antibody (YA6412) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-KB p65.

HY-P86687

	NF-KB p65 Antibody (YA6379) TF65_HUMAN; Transcription factor p65; RELA; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; RELA proto-oncogene, NF-kB subunit; p65; CMCU; NFKB3; AIF3BL3; NF-kB p65/RelA; NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	NF-KB p65 Antibody (YA6379) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-KB p65.

HY-P86720A

	NF-KB p65 Antibody (YA6412)(PBS only) TF65_HUMAN; Transcription factor p65; RELA; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; RELA proto-oncogene, NF-kB subunit; p65; CMCU; NFKB3; AIF3BL3; NF-kB p65/RelA; NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	NF-KB p65 Antibody (YA6412) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-KB p65.

HY-P81238

	Phospho-NF-κB p65 (Ser536) Antibody 3 Publications Verification Phospho-NF-KB p65 (Ser536) ; NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RELA(phospho S536); NF kB p65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; nuclear Factor NF Kappa B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B cells 3; nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; TF65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat, Monkey
	Phospho-NF-κB p65 (Ser536) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-NF-κB p65 (Ser536).

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Name
Email *

	Sorry, but the email address you supplied was invalid.

NF-κB p65 subunit nuclear

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
Products