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Results for "

NK1 receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neurokinin Receptor (141) Apoptosis (1) Bcl-2 Family (1) Cadherin (1) Calcium Channel (1) Caspase (3) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) Drug Metabolite (3) Endogenous Metabolite (9) Fluorescent Dye (1) Interleukin Related (2) Isotope-Labeled Compounds (5) mAChR (2) Mitochondrial Metabolism (2) Neprilysin (1) p38 MAPK (2) Phospholipase (1) Reference Standards (5) SARS-CoV (1) VEGFR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (3) Endocrinology (25) Infection (4) Inflammation/Immunology (26) Metabolic Disease (5) Neurological Disease (119)
Click Chemistry:	Alkynes (1)

145

Inhibitors & Agonists

Peptides

Natural
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Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Neurokinin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0201

Substance P Maximum Cited Publications 31 Publications Verification Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-16346

Netupitant 4 Publications Verification CID 6451149	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect .

HY-109171

Elinzanetant NT-814; BAY3427080	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
Elinzanetant is an orally active and selective *NK-1* and NK-3 receptor antagonist. Elinzanetant alleviates menopause-associated vasomotor symptoms, including hot flashes and night sweats. Elinzanetant reduces estradiol and progesterone levels. Elinzanetant can be used for the research of moderate to severe vasomotor and sleep disorders associated with menopause .

HY-14751

Rolapitant SCH619734	Neurokinin Receptor	Neurological Disease
Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model .

HY-101249

L-732138	Neurokinin Receptor	Neurological Disease Cancer
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human **NK-1 receptors than cloned rat NK-1 receptors*, and has > 1000-fold more potent than human NK-2 and NK-3 receptors*. L-732138 can reduce hyperalgesia and has antitumor action .

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease
GR-73632 is a tachykinin *NK1* receptor agonist. GR-73632 activates spinal *NK1* receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral *NK1* receptors to trigger lacrimation in guinea pigs, and activates central *NK1* receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus .

HY-16436

Rolapitant hydrochloride hydrate SCH619734 hydrochloride hydrate	Neurokinin Receptor	Neurological Disease Cancer
Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model .

HY-108483

RP 67580	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a K_i value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation .

HY-10053

Maropitant 1 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant is an orally active *NK1* receptor antagonist. Maropitant prevents vomiting and inhibits ulcerative dermatitis .

HY-P0061A

Vapreotide acetate 1 Publications Verification RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-14406A

L-733060 hydrochloride 1 Publications Verification	Neurokinin Receptor	Neurological Disease Cancer
L-733060 hydrochloride is a selective neurokinin-1 (NK-1) *receptor* antagonist. L-733060 hydrochloride mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 hydrochloride blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 hydrochloride reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 hydrochloride can be used for the study of chronic orofacial pain .

HY-P0061

Vapreotide 1 Publications Verification RC160; BMY 41606	Neurokinin Receptor	Cancer
Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P0201A

Substance P TFA Maximum Cited Publications 31 Publications Verification Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Substance P TFA (Neurokinin P TFA) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*) .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective **NK₁ receptor antagonist, with K_i** values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with K_i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-122347A

Orvepitant maleate GW823296 maleate	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pK_i of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment .

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-133206A

Fosnetupitant chloride monohydrochloride 1 Publications Verification Pronetupitant chloride monohydrochloride	Neurokinin Receptor	Cancer
Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an *NK1* antagonist with pK_i values of 9.5, 6.1 for human NK1 and NK3 receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant .

HY-P1012

[Sar9,Met(O2)11]-Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

HY-145250

NK1 receptor antagonist 2	Neurokinin Receptor	Neurological Disease
NK1 receptor antagonist 2 is a **NK1 receptor** antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss .

HY-P2000

Septide (Pyr6,Pro9)-Substance P	Neurokinin Receptor	Neurological Disease
Septide ((Pyr6,Pro9)-Substance P) is a potent **NK1 receptor agonist with a K_d** value of 0.55 nM .

HY-17615

Fosnetupitant Pronetupitant	Neurokinin Receptor	Neurological Disease Cancer
Fosnetupitant (Pronetupitant) a methylene phosphate proagent of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pK_i of 9.5 for human NK₁ receptor .

HY-P3092

Phyllomedusin	Neurokinin Receptor	Neurological Disease
Phyllomedusin, an tachykinin decapeptide, is a **NK1 receptor** agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus .

HY-16346S

Netupitant-d6 CID-6451149-d₆	Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist .

HY-151413

MEN 10207 1 Publications Verification	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-178269

SCH-720881	Drug Metabolite Neurokinin Receptor	Neurological Disease
SCH-720881 is the active metabolite of Rolapitant (HY-14751). Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model .

HY-19665

Lanepitant LY303870	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Lanepitant (LY303870) is a selective neurokinin-1 (NK-1) receptor antagonist. Lanepitant blocks neurogenic inflammation and pain transmission by preventing the binding of substance P to *NK-1* receptors on both neuronal and non-neuronal tissues. Lanepitant can be used to study osteoarthritis .

HY-P1738

[Sar9] Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist .

HY-P3890A

Substance P (5-11) TFA	Neurokinin Receptor	Neurological Disease
Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (HY-P0201), is a neuropeptide. Substance P (5-11) TFA TFA binds to **NK-1 tachykinin receptor** .

HY-108479

Nolpitantium SR140333	Neurokinin Receptor	Neurological Disease
Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin **NK₁ receptor** antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P	Neurokinin Receptor	Neurological Disease
(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective **NK₁ receptor** antagonist .

HY-12114

Serlopitant VPD-737; MK-0594	Neurokinin Receptor	Neurological Disease Endocrinology
Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.

HY-108480

SDZ NKT 343	Neurokinin Receptor	Neurological Disease
SDZ NKT 343 is a selective, orally active **NK₁ receptor antagonist with an IC₅₀** of 0.62 nM against human NK₁ receptor. SDZ NKT 343 has good analgesic activity .

HY-P1193

GR 82334	Neurokinin Receptor	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland **NK-1 receptor** and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-G0012

Netupitant metabolite Monohydroxy Netupitant Monohydroxy Netupitant	Neurokinin Receptor Drug Metabolite	Endocrinology
Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-U00207

MEN11467	Neurokinin Receptor	Neurological Disease Endocrinology
MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK₁ receptor antagonist.

HY-P2475

[Pro9]-Substance P	Neurokinin Receptor	Neurological Disease
[Pro9]-Substance P is a potent, reversible and selective agonist of *NK-1* tachykinin receptors with an EC₅₀ of 0.93 nM .

HY-P1379

C14TKL-1	Neurokinin Receptor	Neurological Disease
C14TKL-1 is a tachykinin-like peptide and exhibits an agonistic activity for *neurokinin receptor* 1** (NK-1) .

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (HY-P0201), is a neuropeptide. Substance P (5-11) binds to **NK-1 tachykinin receptor** .

HY-117216

L-703606	Neurokinin Receptor	Neurological Disease
L-703606 is a potent, selective antagonist of *NK1* receptor. L-703606 can be used for study of gastric acid secretion .

HY-10053A

Maropitant citrate hydrate	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Maropitant citrate hydrate is the citrate hydrate of Maropitant (HY-10053). Maropitant is an orally active *NK1* receptor antagonist. Maropitant prevents vomiting and inhibits ulcerative dermatitis .

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (HY-P0201). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect .

HY-137462

Leucyl-phenylalanine amide L-Leucyl-L-phenylalaninamide	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Leucyl-phenylalanine amide (L-Leucyl-L-phenylalaninamide) is a dipeptide analog. Leucyl-phenylalanine amide is a ligand of SP_1-7 with a K_i value of 10.2 nM. Leucyl-phenylalanine amide shows no binding activity to human NK-1 or NK-3 receptors .

HY-14406

L-733060	Neurokinin Receptor	Neurological Disease Cancer
L-733060 is a selective neurokinin-1 (NK-1) *receptor* antagonist. L-733060 mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 can be used for the study of chronic orofacial pain .

HY-118356

WIN 62,577	Neurokinin Receptor mAChR	Neurological Disease
WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

HY-109147A

Imnopitant dihydrochloride	Neurokinin Receptor	Neurological Disease
Imnopitant dihydrochloride is a neurokinin **NK1 receptor** antagonist .

Cat. No.	Product Name	Target	Research Area

HY-P0201

Substance P Maximum Cited Publications 31 Publications Verification Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P0187

Senktide 3 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC₅₀=0.5-3 nM). Senktide less potently agonizes the *NK1* receptor (EC₅₀=35 µM). Senktide is promising for research of neurological disease .

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease
GR-73632 is a tachykinin *NK1* receptor agonist. GR-73632 activates spinal *NK1* receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral *NK1* receptors to trigger lacrimation in guinea pigs, and activates central *NK1* receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus .

HY-P0061A

Vapreotide acetate 1 Publications Verification RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

HY-P0061

Vapreotide 1 Publications Verification RC160; BMY 41606	Neurokinin Receptor	Cancer
Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P0201A

Substance P TFA Maximum Cited Publications 31 Publications Verification Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Substance P TFA (Neurokinin P TFA) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*) .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective **NK₁ receptor antagonist, with K_i** values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with K_i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1012

[Sar9,Met(O2)11]-Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

HY-P2000

Septide (Pyr6,Pro9)-Substance P	Neurokinin Receptor	Neurological Disease
Septide ((Pyr6,Pro9)-Substance P) is a potent **NK1 receptor agonist with a K_d** value of 0.55 nM .

HY-P3092

Phyllomedusin	Neurokinin Receptor	Neurological Disease
Phyllomedusin, an tachykinin decapeptide, is a **NK1 receptor** agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus .

HY-P1722

Spantide II 1 Publications Verification	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis .

HY-151413

MEN 10207 1 Publications Verification	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P0201AF

Substance P, FAM-labeled TFA	Fluorescent Dye Endogenous Metabolite	Cancer
Substance P, FAM-labeled (TFA) is Substance P TFA (HY-P02101A) labeled with FAM fluorophore. Substance P TFA (Neurokinin P TFA) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The endogenous receptor of Substance P is neurokinin 1 receptor (NK1R) .

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Neurological Disease Metabolic Disease
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

HY-P1738

[Sar9] Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist .

HY-P3890A

Substance P (5-11) TFA	Neurokinin Receptor	Neurological Disease
Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (HY-P0201), is a neuropeptide. Substance P (5-11) TFA TFA binds to **NK-1 tachykinin receptor** .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P	Neurokinin Receptor	Neurological Disease
(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective **NK₁ receptor** antagonist .

HY-P11312

[S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
[S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10) is a neuropeptide A analog and a peptide fragment of EB1002 (HY-P10746). [S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10) is highly selective for mouse tachykinin receptors and human tachykinin receptor *NK1R* .

HY-P1193

GR 82334	Neurokinin Receptor	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland **NK-1 receptor** and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-P2475

[Pro9]-Substance P	Neurokinin Receptor	Neurological Disease
[Pro9]-Substance P is a potent, reversible and selective agonist of *NK-1* tachykinin receptors with an EC₅₀ of 0.93 nM .

HY-P1379

C14TKL-1	Neurokinin Receptor	Neurological Disease
C14TKL-1 is a tachykinin-like peptide and exhibits an agonistic activity for *neurokinin receptor* 1** (NK-1) .

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (HY-P0201), is a neuropeptide. Substance P (5-11) binds to **NK-1 tachykinin receptor** .

HY-P3852

*Neurokinin Receptor* (393-407), rat** SPR393-407	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat *neurokinin 1 receptor* (NK1R)** fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation .

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (HY-P0201). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect .

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

HY-P3891

Substance P (4-11)	Neurokinin Receptor	Neurological Disease
Substance P (4-11), the C-terminus fragment of Substance P (HY-P0201), is a Substance P agonist that shows highly selective for **NK1 receptors** .

HY-P0061B

Vapreotide diacetate RC160 diacetate; BMY 41606 diacetate	Neurokinin Receptor	Cancer
Vapreotide diacetate is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-105436

FR 113680	Neurokinin Receptor	Neurological Disease
FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective **NK₁ receptor antagonist, with K_i** values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1194B

[D-Pro2] Spantide I TFA	Neurokinin Receptor	Neurological Disease
[D-Pro2] Spantide I TFA is a Spantide analog. Spantide I is a selective NK1 receptor antagonist .

HY-P1012A

[Sar9,Met(O2)11]-Substance P TFA	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for *NK-1, NK-2,and NK-3* receptor, respectively .

HY-P10588

WIN 66306	Neurokinin Receptor	Others
WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both *NK1* and NK2 receptors .

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1379A

C14TKL-1 acetate	Neurokinin Receptor	Neurological Disease
C14TKL-1 acetate is the acetate salt form of C14TKL-1 (HY-P1379). C14TKL-1 acetate is a tachykinin-like peptide and exhibits an agonistic activity for *neurokinin receptor* 1** (NK-1) .

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .

HY-P10619

[Tyr6,D-Phe7,D-His9]-Substance P (6-11)	Neurokinin Receptor	Inflammation/Immunology
[Tyr6,D-Phe7,D-His9]-Substance P (6-11) is a tachykinin *NK1* receptor antagonist that antagonizes Histamine (HY-B1204) induced hyperalgesia .

HY-W755425

Senktide TFA	Neurokinin Receptor	Neurological Disease
Senktide TFA is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC₅₀=0.5-3 nM). Senktide TFA less potently agonizes the *NK1* receptor (EC₅₀=35 µM). Senktide TFA is promising for research of neurological disease .

HY-P2139

Ranakinin	Neurokinin Receptor Phospholipase	Others
Ranakinin is a NK1R agonist. Ranakinin inhibits the binding of selective *NK1* radioligands to *NK1* receptors. Ranakinin activates phospholipase C (Phospholipase C), thereby enhancing polyphosphoinositide hydrolysis. Ranakinin stimulates inositol phosphate production and reduces membrane polyphosphoinositide levels. Ranakinin stimulates corticosterone and aldosterone secretion .

HY-P2593

L-659874	Neurokinin Receptor	Neurological Disease
L-659874 is a selective NK2 receptor antagonist with an IC₅₀ value of 0.49 μM in hamsters. L-659874 inhibits NK2 receptor-mediated hydrolysis of inositol phospholipids. L-659874 could be used for research on the correlation between pain signal transduction and smooth muscle responses. .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0201

Substance P Maximum Cited Publications 31 Publications Verification Neurokinin P	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Neurokinin Receptor Endogenous Metabolite
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-W011978

N-Acetyl-L-tryptophan	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to *NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β* and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-P0255

Physalaemin	Animals Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Endocrinology Source Classification	Neurokinin Receptor
Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) *receptor* with high affinity.

HY-114673

Benzomalvin B	Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Quinoline Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Neurokinin Receptor
Benzomalvin B is the less active analogs of Benzomalvin A. Benzomalvin B is weakly active against substance P .

HY-118463

Benzomalvin A (-)-Benzomalvin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Quinoline Alkaloids Endogenous metabolite Source Classification	Neurokinin Receptor
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively .

HY-119552

Acetylaszonalenin LL-S490β	Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Neurokinin Receptor
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-116620

Benzomalvin C	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Neurokinin Receptor
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC₅₀ value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

HY-N9554

WIN-64821	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Neurokinin Receptor Endogenous Metabolite Calcium Channel
WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The K_i values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca ²⁺ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research .

Cat. No.	Product Name	Chemical Structure

HY-16346S

Netupitant-d6
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist .

HY-10053S

Maropitant-d3
Maropitant-d₃ is the deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting .

HY-W011978S

N-Acetyl-L-tryptophan-d3

N-Acetyl-L-tryptophan-d₃ is the deuterium labeled N-Acetyl-L-tryptophan (HY-W011978). N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-10053S1

Maropitant-13C,d3
Maropitant- ¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting .

HY-12142S

rac-Vofopitant-d3

rac-Vofopitant-d₃ (rac-GR 205171-d₃) is a racemic form of deuterated Vofopitant (HY-12142). Vofopitant (GR 205171A) is a blood-brain barrier-permeable NK1 receptor inhibitor with a pKi of 9.02 in mice. Vofopitant blocks vomiting-related responses and inhibits pseudoptyalism. Vofopitant exerts anxiolytic effects, regulates 5-HT receptor function and increases central 5-HT release. Vofopitant improves hyperarousal symptoms of post-traumatic stress disorder. Vofopitant can be used in research related to depression, anxiety, vomiting and postoperative nausea and vomiting .

HY-109171S

Elinzanetant-d3
Elinzanetant-d₃ (NT-814-d₃) is deuterium labeled Elinzanetant. Elizanetant (NT-814) is an orally active, selective *NK-1,3* receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women .

Cat. No.	Product Name		Classification

HY-105346

WIN 51708		Alkynes
WIN 51708 is a nonpeptide antagonist of neurokinin (NK)-1 receptor. WIN 51708 has a higher affinity for the rat NK-1 receptor compared to the human NK-1 receptor .

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