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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
PFAS
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "PFAS" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-DY3003
(S)-Batylalcohol (1-O-Octadecyl-sn-glycerol) is a phosphonoformic acid (PFA) analog that exhibits higher in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1) than PFA. (S)-Batylalcohol can be used in antiretroviral research .
Cat. No.: HY-W142432
CAS No.: 2058-94-8
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Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .
Cat. No.: HY-115701
CAS No.: 154436-49-4
Synonyms: 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE
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1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
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Synonyms: 1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS
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Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS) is a per- and polyfluoroalkyl substance (PFAS) that penetrates the skin and induces systemic toxicity and immunotoxicity. Perfluoroheptanesulfonic acid reduces the expression of PPARδ in liver tissue; it induces hepatocyte hypertrophy and necrosis in liver tissue and alters serum biochemical markers associated with liver injury. Perfluoroheptanesulfonic acid upregulates genes related to fatty acid metabolism, cell necrosis and inflammation, reduces the relative weights of the spleen and thymus, suppresses humoral immune responses, and alters the composition of immune cell subsets in the spleen and skin. The plasma concentration of Perfluoroheptanesulfonic acid correlates with food intake. Perfluoroheptanesulfonic acid and perfluorooctanesulfonic acid exhibit synchronous pulse events in influent samples from wastewater treatment plants. Perfluoroheptanesulfonic acid can be used in studies related to liver injury and immune system damage .
Cat. No.: HY-W792491
CAS No.: 423-41-6
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Perfluoropropanesulfonic acid is an ultrashort-chain per- and polyfluoroalkyl substance (PFAS). Perfluoropropanesulfonic acid is an environmental pollutant .
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Aldose Reductase Glutathione Reductase (GR) p38 MAPK ERK JNK Reactive Oxygen Species (ROS) Apoptosis Drug Intermediate
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Glyoxal (40% w/w in water) is an α-oxoaldehyde that inhibits Aldose Reductase, Glutathione Reductase, and NADPH synthase. Glyoxal (40% w/w in water) exhibits cytotoxicity, triggers oxidative stress, induces ROS accumulation, lipid peroxidation, mitochondrial membrane potential collapse, DNA damage, apoptosis, and massive production of advanced glycation end products (AGEs). Glyoxal (40% w/w in water) depletes glutathione and activates MAPK phosphorylation. It has lower toxicity as a fixative than paraformaldehyde (PFA) and serves as a precursor for the synthesis of oxalates and dietary carcinogens. Glyoxal (40% w/w in water) is suitable for research related to calcium oxalate kidney stones, diabetes, atherosclerosis, cardiovascular diseases, retinopathy, and cataracts .
Cat. No.: HY-W674169
CAS No.: 30334-69-1
Synonyms: FBSA
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Perfluorobutanesulfonamide (FBSA) is a per- and polyfluoroalkyl substance, which can be found as contaminant in wastewater .
Cat. No.: HY-W679758
CAS No.: 39108-34-4
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1H,1H,2H,2H-Perfluorodecanesulfonic acid (8:2 FTS) is a precursor of perfluorinated and polyfluoroalkyl substances (PFAS). PFAS is a class of organic compounds .
Cat. No.: HY-W080797
CAS No.: 356-02-5
Synonyms: 3:3 FTCA
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4,4,5,5,6,6,6-Heptafluorohexanoic acid (3:3 FTCA) is a polyfluoroalkyl substance (PFAS) that accumulate in the environment. 3:3 FTCA binds to many proteins, including the primary human serum transport protein albumin (HSA) .
Cat. No.: HY-RS10357
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PFAS Human Pre-designed siRNA Set A contains three designed siRNAs for PFAS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19931
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Pfas Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pfas gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26433
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Pfas Rat Pre-designed siRNA Set A contains three designed siRNAs for Pfas gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28695
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Fnta Rat Pre-designed siRNA Set A contains three designed siRNAs for Fnta gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-187595
CAS No.: 114753-71-8
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Khl 8430 is a Calmodulin antagonist. It binds to both free calmodulin and calmodulin-enzyme complexes, thereby abolishing the regulatory effects of calmodulin on phosphofructokinase (PFA) and phosphodiesterase. Khl 8430 is applicable for studies of calmodulin-related signaling pathways .
Cat. No.: HY-181266
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Antimalarial agent 55 is an orally potent inhibitor of PfA-M1 and PfA-M17 aminopeptidases from Plasmodium falciparum, with Ki values of 27 nM and 81 nM, respectively. Antimalarial agent 55 exhibits potent nanomolar activity against homologous enzymes from Plasmodium vivax and Plasmodium berghei, with Ki values of 2 nM, 4 nM, 190 nM and 18 nM for Pv-M1, Pb-M1, Pv-M17 and Pb-M17, respectively. Antimalarial agent 55 possesses significant antiplasmodial activity, as well as cross-species inhibitory capacity and broad-spectrum activity that is unaffected by existing drug resistance mechanisms. Antimalarial agent 55 can be used in malaria research .
Cat. No.: HY-184758
CAS No.: 10567-22-3
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3-O-Octadecyl-sn-glycerol is an ether lipid that serves as an enantiopure substrate for evaluating the stereoselectivity of lipases in oleic acid esterification reactions. 3-O-Octadecyl-sn-glycerol can be used for the synthesis of AZT-lipid-PFA antiviral dual drugs. 3-O-Octadecyl-sn-glycerol acts as a biochemical reagent for research in various fields .
Cat. No.: HY-W142432S
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
