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GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0873

PEG300 Maximum Cited Publications 178 Publications Verification Polyethylene glycol 300	Environmental Pollutants Biochemical Assay Reagents	Others
PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .

HY-Y0873C

PEG3350 Polyethylene glycol 3350	Environmental Pollutants Biochemical Assay Reagents	Others
PEG3350 (Polyethylene glycol 3350) a neutral polymer of molecular weight 3350. PEG3350 used as an excellent solvent for a large number of substances.

HY-W007432

RuPhos	Biochemical Assay Reagents	Others
RuPhos is a Buchwald ligand. In aqueous Suzuki-Miyaura catalytic transfer polymerization, RuPhos forms inactive Pd (RuPhos)₂ with palladium and inhibits diffusion to improve polymerization controllability. RuPhos additional addition in anhydrous Kumada polymerization exacerbates catalyst deactivation and chain transfer, significantly impairing polymerization control .

HY-D1005A2

Poloxamer 105 (L35) PEG-PPG-PEG, 1900 (Average)	Environmental Pollutants Biochemical Assay Reagents	Others
Poloxamer 105 L35 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1900 Da. Poloxamer 105 L35 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-W012723

2-Hydroxyethyl methacrylate	Biochemical Assay Reagents	Others
2-Hydroxyethyl methacrylate (HEMA) is a monomer used in the synthesis of various polymers, and the polymer PHEMA of 2-Hydroxyethyl methacrylate is widely used in the synthesis of dental composite materials .

HY-Y0850U4

PVA (Mw 145000, 99+% hydrolyzed, ~3300 polymerization) 1 Publications Verification Polyvinyl alcohol (Mw 145000, 99+% hydrolyzed, ~3300 polymerization); Poly(Ethenol) (Mw 145000, 99+% hydrolyzed, ~3300 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 145000, 99+% hydrolyzed, ~3300 polymerization) is a polyvinyl alcohol with molecular weight of 145000 with hydrolysis properties. PVA (Mw 145000, 99+% hydrolyzed, ~3300 polymerization) is obtained by polymerizing vinyl acetate followed by hydrolysis to remove acetate groups, yielding polyvinyl alcohol .

HY-W089777

3-Glycidyloxypropyltrimethoxysilane GPTMS	Biochemical Assay Reagents	Others
3-Glycidyloxypropyltrimethoxysilane (GPTMS) is a silicon source for the preparation of inorganic-organic hybrid polymers. 3-Glycidyloxypropyltrimethoxysilane can be used to prepare hard coatings of organic polymers, such as contact lens materials in the optical industry, as well as related materials in the fields of electronics, thin films, sensors, nanoimprinting, waveguides, and biology .

HY-W013021

Norbornene	Ligands for E3 Ligase	Others
Norbornene is a cycloolefin and building block for synthesis of porous organic polymeric materials via metathesis, addition, and CANAL polymerization. Norbornene can also be used as an E3 ligase ligand for the synthesis of PROTAC, such as PROTAC HyTTD Degrader-1 (HY-181895) .

HY-W105423

Methacrylic acid N-hydroxysuccinimide ester NHS-MA	Biochemical Assay Reagents	Others
Methacrylic acid N-hydroxysuccinimide ester (NHS-MA) is a polymer that serves as a monomer to prepare degradable amphiphilic block copolymer microparticles via RAFT polymerization for low pH-triggered drug delivery. Methacrylic acid N-hydroxysuccinimide ester is used for the synthesis of nanogels .

HY-W013205

Bis(4-nitrophenyl) phosphate	Biochemical Assay Reagents	Others
Bis(4-nitrophenyl) phosphate is a catalyst for metal micelles and can catalyze the hydrolysis of (4-nitrophenyl) phosphate. Bis(4-nitrophenyl) phosphate is also an effective catalyst for ring-opening polymerization (ROP), which can achieve controlled polymerization of β-butyrolactone (β-BL) ring-opening and can be used to prepare diembedded polymers without quenching. segment copolymer .

HY-A0104K

HPMC (Type II,Viscosity:3mPa.s) Hypromellose (Type II,Viscosity:3mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:3mPa.s); Celacol HPM 5000 (Type II,Viscosity:3mPa.s)	Environmental Pollutants Biochemical Assay Reagents	Others
HPMC (Type II, Viscosity: 3 mPa.s) is a nonionic polymer prepared via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, which includes the diffusion of drugs in the hydrated matrix and the polymer relaxation process .

HY-W923198

Fluorescein O-methacrylate Methacryloyloxy fluorescein	Fluorescent Dye	Others
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm) .

HY-W440548

Ethylene glycol diacrylate Ethylene diacrylate	Biochemical Assay Reagents	Others
Ethylene glycol diacrylate (Ethylene diacrylate) is a polymer precursor used to form covalently crosslinked hydrogels with a degree of polymerization of 13 .

HY-139480

Poly(ethylene glycol) dithiol (Mn 3400)	Biochemical Assay Reagents	Others
Poly(ethylene glycol) dithiol (Mn 3400) is a polymer and can be used as a biomaterial to prepare hydrogels .

HY-N1915

Cellohexaose	Endogenous Metabolite	Metabolic Disease
Cellohexaose is a glucose polymer with two or more glucose monomers produced from the breakdown of cellulose, consisting of a condensation of beta (1-4) linked D-glucose monomers .

HY-W015553

2-Vinylnaphthalene 2-Ethenylnaphthalene; 2-Vinylnaphthalene	Biochemical Assay Reagents	Others
2-Vinylnaphthalene (2-Ethenylnaphthalene; 2-Vinylnaphthalene) is an organic polymer. 2-Vinylnaphthalene is a kind of biological materials or organic compounds that are widely used in life science research .

HY-Y0850U2

PVA (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization) Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization) (Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization)) is a biodegradable of polymer. PVA (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization) can be used to blend with various biopolymers and hydrophilic synthetic polymers to improve mechanical properties of films .

HY-Y0850U1

PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization) Polyvinyl alcohol (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization); Poly(Ethenol) (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization) (Polyvinyl alcohol (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization); Poly(Ethenol) (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization)) is a biodegradable of polymer. PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization) can be used to produce bio-composite films .

HY-Y0850U7

PVA (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization) Polyvinyl alcohol (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization); Poly(Ethenol) (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization) is polyvinyl alcohol with a molecular weight of 195,000 and hydrolytic properties. PVA (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization) is obtained by polymerizing vinyl acetate followed by hydrolysis to remove acetate groups, yielding polyvinyl alcohol .

HY-176499

PLGA38000-PEG10000 1 Publications Verification	Biochemical Assay Reagents	Others
PLGA38000-PEG10000 is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .

HY-Y0850U

PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization) Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ~630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ~630 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization) (Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ~630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ~630 polymerization)) is a biocompatible, biodegradable, nontoxic and hydrophilic synthetic polymer. PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization) can be used to produce bone tissue engineering scaffold ^[1]

HY-Y0850U8

PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) Polyvinyl alcohol (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization); Poly(Ethenol) (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) is a polyvinyl alcohol with molecular weight of 47000 with hydrolysis properties. Hydrolysis degree refers to the conversion rate of acetic acid group hydrolysis to hydroxyl group in the original polyvinyl acetate, PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization). In addition, polyvinyl alcohol is obtained from polymerization of vinyl acetate to remove acetic acid group by hydrolysis. Polyvinyl alcohol with different degrees of hydrolysis can be self-crosslinked to form frozen gels and used as biological excipients .

HY-D1005A7

Poloxamer 125 (L45) PEG-PPG-PEG, 2400 (Average)	Biochemical Assay Reagents	Others
Poloxamer 125 L45 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2400. Poloxamer 125 L45 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-164077

mPEG-PLGA	Biochemical Assay Reagents	Others
mPEG-PLGA is a mucus-penetrating polymer. mPEG-PLGA is a raw material to prepare nanomedicine .

HY-147896

Tubulin polymerization-IN-29	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-29 (compound 6g) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-29 exhibits potent antiproliferative activity. Tubulin polymerization-IN-29 can induce HeLa cells arrest in G2/M phase .

HY-W321446

Dansyl ethylenediamine	Fluorescent Dye	Others
Dansyl ethylenediamine is a fluorescent probe. Dansyl ethylenediamine can be used for synthesis of protein-imprinted polymers which is capable of specific transduction of protein binding events into fluorescent signal change .

HY-149016

Tubulin polymerization-IN-25	Microtubule/Tubulin Farnesyl Transferase	Cancer
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC₅₀s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

HY-167006

PLGA10000-PEG3000-VS PLGA10000-PEG3000-Vinylsulfone	Biochemical Assay Reagents	Others
PLGA10000-PEG3000-VS (PLGA10000-PEG3000-Vinylsulfone) is an amphiphilic polymer. Amphiphilic polymers can be used in drug delivery studies due to their ability to self-assemble into discrete aggregates .

HY-143446

Tubulin polymerization-IN-7	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-7 (compound 5) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-7 has the potential for the research of cancer diseases .

HY-145868

Tubulin polymerization-IN-3	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-3 (compound 4c) is a potent tubulin polymerization inhibitor, with an IC₅₀ of 3.84 µM. Tubulin polymerization-IN-3 can induce apoptosis in colon cancer cells .

HY-176201

Tubulin polymerization-IN-80	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-80 (Compound 32) is a potent tubulin polymerization inhibitor with antiproliferative activity. Tubulin polymerization-IN-80 disrupts microtubule formation and leads to cell cycle arrest and apoptosis. Tubulin polymerization-IN-80 is promising for research of cancers .

HY-146362

Tubulin polymerization-IN-17	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-17 (compound 23g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-17 exhibits tubulin depolymerization and induced cell apoptosis and inhibits migration. Tubulin polymerization-IN-17 has the potential for the research of cancer diseases .

HY-146378

Tubulin polymerization-IN-20	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-20 (compound 11) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-20 has the potential for the research of breast cancers and chemoresistant colon cancers .

HY-146377

Tubulin polymerization-IN-19	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-19 (compound 4) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-20 has the potential for the research of breast cancers and chemoresistant colon cancers .

HY-146376

Tubulin polymerization-IN-18	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-18 (compound 8) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-18 has the potential for the research of breast cancers and chemoresistant colon cancers .

HY-146310

Tubulin polymerization-IN-15	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-15 (compound 4) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-15 has the potential for the research of cancer diseases .

HY-146211

Tubulin polymerization-IN-14	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-14 (Compound 20a) is a tubulin polymerization inhibitor with an IC₅₀ of 3.15 μM. Tubulin polymerization-IN-14 shows potent anti-vascular and anticancer activities, induces cancer cell apoptosis .

HY-151982

Tubulin polymerization-IN-39	Microtubule/Tubulin	Cardiovascular Disease Cancer
Tubulin polymerization-IN-39 is a tubulin polymerization inhibitor (IC₅₀: 4.9 μM). Tubulin polymerization-IN-39 occupies the colchicine-binding site. Tubulin polymerization-IN-39 inhibits cancer cell proliferation .

HY-162126

Tubulin polymerization-IN-58	Microtubule/Tubulin YAP	Cancer
Tubulin polymerization-IN-58 (Compound K18) is a tubulin polymerization inhibitor with an IC₅₀ of 0.446 μM. Tubulin polymerization-IN-58 also induces the degradation of oncogenic protein YAP via the UPS pathway, thus can be used for cancer research .

HY-143447

Tubulin polymerization-IN-8	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-8 concentration-dependently causes cell cycle arrest at the G2/M phase in HCT116 tumor cells, and displays a significant inhibition of tubulin polymerization with an IC₅₀ value of 12.7 μM. Tubulin polymerization-IN-8 has the potential for the research of cancer diseases ^{[ 1]}.

HY-156737

Tubulin polymerization-IN-49	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-49 (compound 12d) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-49 bound to colchicine site on tubulin and inhibited tubulin polymerization. Tubulin polymerization-IN-49 induces cell cycle arrest at G2/M phase and apoptosis. Tubulin polymerization-IN-49 has anticancer active and prevents tumor generation, inhibits tumor proliferation and angiogenesis .

HY-146164

Tubulin polymerization-IN-21	Microtubule/Tubulin	Metabolic Disease Cancer
Tubulin polymerization-IN-21 (compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-21 exhibits anti-cancer activity through disrupting cellular integrity and affecting glucose metabolism .

HY-149363

Tubulin polymerization-IN-43	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis .

HY-147824

Tubulin polymerization-IN-22	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-22 is a tubulin polymerization inhibitor with an IC₅₀ of 8.1 μM. Tubulin polymerization-IN-22 arrests cell cycle at G2/M phase and induces apoptosis .

HY-146311

Tubulin polymerization-IN-16	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC₅₀ values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells .

HY-127042

6,7-Epoxy-latrunculin A 6,7-Epoxy-LAT-A	Arp2/3 Complex	Others
6,7-Epoxy-latrunculin A can be isolated from the Red Sea sponge Negombata magnifica and is initially identified as an inhibitor of actin polymerization by its morphological effects .

HY-155314

Tubulin polymerization-IN-50	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-50 (compound 7n) is a inhibitor of tubulin polymerization, with the IC₅₀ of 5.05 μM in SK-Mel-28 cells. Tubulin polymerization-IN-50 induces the cell cycle arrest in the G2/M phase .

HY-146863

Tubulin polymerization-IN-10	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-10 is a potent tubulin polymerization inhibitor with an IC₅₀ of 4.25±0.75 μM. Tubulin polymerization-IN-10 has anti-tumor effects .

HY-155139

Tubulin polymerization-IN-45	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-45, a tubulin-targeting agent, is a tubulin polymerization inhibitor. Tubulin polymerization-IN-45 binds to the colchicine site of tubulin. Tubulin polymerization-IN-45 induces apoptotic cell death in hepatocellular cancer (HCC) cells .

HY-152088

Neuroinflammatory-IN-3	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology Cancer
Neuroinflammatory-IN-3, a tubulin inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization_[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0015

Paclitaxel Maximum Cited Publications 354 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Microtubule/Tubulin ADC Payload Apoptosis Autophagy
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-Y0479

L-Lactic acid 10+ Cited Publications (S)-2-Hydroxypropanoic acid	Structural Classification Classification of Application Fields Endocrine diseases Endogenous metabolite Infection Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder Source Classification	Environmental Pollutants Antibiotic Endogenous Metabolite Bacterial
L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid has antiproliferative activity .

HY-16928

Cytochalasin B 40+ Cited Publications Phomin	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification Cancer	Arp2/3 Complex
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

HY-16569

Colchicine 60+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-Y0520

Itaconic acid 2 Publications Verification Methylenesuccinic acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Ferroptosis
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect .

HY-N0282

Demecolcine 5+ Cited Publications	Alkaloids other families Classification of Application Fields Other Alkaloids Plants Inflammation/Immunology Disease Research Fields Source Classification	Microtubule/Tubulin Apoptosis
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-101848

Latrunculin B 5+ Cited Publications	Infection Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields	Fungal
Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity .

HY-P0027

Jasplakinolide Maximum Cited Publications 9 Publications Verification	Antifungal Classification of Application Fields Marine natural products Disease Research Other Antibiotics Infection Monophenols Animals Antibiotics Cyclopeptides Phenols Sponge Anticancer Disease Research Fields Source Classification	Arp2/3 Complex Fungal
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

HY-16929

Latrunculin A 10+ Cited Publications LAT-A	Macrolide Antibiotics Animals Classification of Application Fields Antibiotics Marine natural products Other Diseases Sponge Disease Research Anticancer Disease Research Fields Source Classification	Arp2/3 Complex
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-Y1310

Sodium alginate 1 Publications Verification	Marine natural products Source Classification	Environmental Pollutants
Sodium alginate is the sodium salt of alginic acid. Sodium alginate can be extracted and purified from brown seaweed Laminaria japonica. Sodium alginate can be used in food additives and pharmaceuticals, adsorb heavy metal ions, and has mucosal-protective and hemostatic effects .

HY-Y0335

1,3-Dihydroxyacetone Dihydroxyacetone	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Bacterial Antibiotic Drug Intermediate
1,3-Dihydroxyacetone (DHA), the main active ingredient in sunless tanning skin-care preparations and an important precursor for the synthesis of various fine chemicals, is produced on an industrial scale by microbial fermentation of glycerol (HY-B1659) in Gluconobacter oxydans. 1,3-Dihydroxyacetone is also used for synthesis of new biodegradable polymers by combining with lactic acid (HY-B2227) .

HY-125527

Resolvin D1 1 Publications Verification RvD1	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology Source Classification	Endogenous Metabolite
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-19474

Maytansinol Ansamitocin P-0	Alkaloids Microorganisms Other Alkaloids Disease Research Fields Source Classification Cancer	Microtubule/Tubulin ADC Payload Apoptosis
Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research .

HY-B0015R

Paclitaxel (Standard)	Structural Classification Terpenoids Taxaceae Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Reference Standards Microtubule/Tubulin ADC Payload Apoptosis Autophagy
Paclitaxel (Standard) is the analytical standard of Paclitaxel. This product is intended for research and analytical applications. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-N6070

Ricinoleic acid (purity≥85%)	Structural Classification Classification of Application Fields Ricinus communis L. Ketones, Aldehydes, Acids Other Diseases Euphorbiaceae Plants Disease Research Fields Source Classification	Environmental Pollutants Prostaglandin Receptor
Ricinoleic acid (purity≥85%), a hydroxy fatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC₅₀ in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .

HY-111830

Lignin 1 Publications Verification Lignine	Structural Classification other families Classification of Application Fields Lignans Other Diseases Phenylpropanoids Plants Disease Research Fields Source Classification	Environmental Pollutants
Lignin (Lignine) is a natural complex biopolymer with biodegradable and biocompatible. Lignin is the main component of plant cell walls and is a renewable aromatic polymer. Lignin has strongly antioxidant activity .

HY-N3018

Isomaltose 6-O-α-D-Glucopyranosyl-D-glucose; D-Isomaltose	Structural Classification Human Gut Microbiota Metabolites Polysaccharides Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite Parasite
Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose) is a glucose disaccharide. Isomaltose induces G-CSF secretion via heat-induced oxidative polymerization of glucose groups into high-molecular-weight compounds. Isomaltose modulates cecal bacterial cluster structure in mice. Isomaltose exhibits low glycemic index, slow hydrolysis, and prebiotic properties. Isomaltose reduces in vivo Cryptosporidium parvum colonization in neonatal mice. Isomaltose can be used for the research of Cryptosporidium parvum infection .

HY-N6682

Cytochalasin D 90+ Cited Publications Zygosporin A; NSC 209835	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Exosomes Arp2/3 Complex Antibiotic YAP
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-W007656

Cyclen	Structural Classification Natural Products Classification of Application Fields Other Diseases Plants Menispermaceae Disease Research Fields Stephania japonica (Thunb.) Miers Source Classification	Biochemical Assay Reagents
Cyclen is a macrocyclic tetraamine chelating agent. Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates. Cyclen is employed as a structural regulator through interfacial polymerization of polyethleneimine (PEI) and trimesoyl chloride (TMC) to develop polyamide NF membrane with efficient Li ⁺/Mg ²⁺ separation performance. Cyclen has specific cavity structure and exhibits selective coordination properties for Li ⁺ ions ^[1][2].

HY-15580

Dolastatin 10 DLS 10; NSC 376128	Natural Products Classification of Application Fields Marine natural products Other marine organisms Disease Research Fields Source Classification Cancer	Microtubule/Tubulin ADC Payload
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

HY-32004

Coumalic acid	Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Smilacis Glabrae Rhizoma Plants Disease Research Fields Source Classification	Endogenous Metabolite Parasite Hydroxycarboxylic Acid Receptor (HCAR)
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (K_I = 0.073 μM for hCA IX; K_I = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity .

HY-W002105

2,5-Furandicarboxylic acid 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Biochemical Assay Reagents
2,5-Furandicarboxylic acid, detected in human urine, is an important renewable biotechnological building block because it serves as an environmentally friendly substitute for terephthalic acid in the production of polyesters. 2,5-Furandicarboxylic acid can be used as the raw material for various chemical intermediates to synthesize polymers, polyurethanes, thermosetting resins, plasticizers, fungicides, macrocyclic ligands and other products .

HY-W013021

Norbornene	Structural Classification Natural Products Mangifera pajang Kosterm. Plants Anacardiaceae Source Classification	Ligands for E3 Ligase
Norbornene is a cycloolefin and building block for synthesis of porous organic polymeric materials via metathesis, addition, and CANAL polymerization. Norbornene can also be used as an E3 ligase ligand for the synthesis of PROTAC, such as PROTAC HyTTD Degrader-1 (HY-181895) .

HY-N1131

Triacetonamine 1 Publications Verification 2,2,6,6-Tetramethyl-4-piperidone	Tribulus terrester Linn. Alkaloids Piperidine Alkaloids Classification of Application Fields Zygophyllaceae Other Diseases Plants Disease Research Fields Source Classification	Others
Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine has oral activity and can induce acute liver failure (ALF) in rats .

HY-W014410

Mucic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
Mucic acid (Galactaric acid) is a building block for polymers. Mucic acid stimulates Runx2 mRNA expression. Mucic acid can be used in polymer synthesis and bone tissue engineering research .

HY-13503

Epothilone A 1 Publications Verification Epo A	Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Source Classification Cancer	Microtubule/Tubulin Apoptosis
Epothilone A is a competitive inhibitor of the binding of [ ³H] paclitaxel to tubulin polymers, with a K_i of 0.6-1.4 μM.

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Source Classification Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin ADC Payload
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-138962

κ-Carrageenan K-Carrageenan Karra Type	Structural Classification Natural Products other families Classification of Application Fields Red seaweeds Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	Apoptosis
κ-Carrageenan is a natural polymer which predominantly available in red seaweeds. κ-Carrageenan is an effective agent carrier to deliver curcumin in cancer cells and to induce apoptosis. κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation .

HY-W015302

2-Aminobenzenesulfonic acid Orthanilic acid; 2-Aminobenzenesulphonic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
2-Aminobenzenesulfonic acid is an anilinesulfonic acid and also the ortho-isomer of aminobenzenesulfonic acid. 2-Aminobenzenesulfonic acid can be used in the synthesis of other active compounds. 2-Aminobenzenesulfonic acid can coordinate via its -NH₂ and -SO₃ groups to form polymeric copper (II) complexes .

HY-W000800

cis,cis-Muconic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Bacterial
cis,cis-Muconic acid is a dicarboxylic acid produced by Saccharomyces cerevisiae. cis,cis-Muconic acid shows pH-dependent toxicity against Saccharomyces cerevisiae CEN.PK113-7D. cis,cis-Muconic acid can be used as intermediate for the production of various plastics and polymers .

HY-N6613

Polygalacturonic acid Galacturonic acid polymer	Infection Natural Products Polysaccharides Classification of Application Fields Malus pumila Mill. Rosaceae Plants Inflammation/Immunology Disease Research Fields Saccharides	Others
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity .

HY-N7053

Tubulysin M	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification Cancer	ADC Payload Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-W145520

Amylopectin	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Biochemical Assay Reagents
Amylopectin is a branched glucan polymer and one of the two principal components of starch, found in botanical sources including corn, amaranth, and potato .

HY-107378

L-Valyl-L-phenylalanine Valylphenylalanine; H-VAL-PHE-OH	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has been reported as biocompatible polymer.

HY-132188

Manganese peroxidase	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Manganese peroxidase is a heme protein that oxidizes Mn2+ to Mn3+. Manganese peroxidase catalyzes plant lignin de-polymerization. Manganese peroxidase can be used for the biodegradation of hazardous environmental contaminants, and especially for dye wastewater decolorization .

HY-N7697B

Chitobiose dihydrochloride	Structural Classification Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Others
Chitobiose dihydrochloride is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose dihydrochloride shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose dihydrochloride can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

HY-N6836

Fructo-oligosaccharide DP8/GF7	Polysaccharides Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Saccharum officinarum Saccharides Source Classification	Others
Fructo-oligosaccharide DP8/GF7 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=8). Fructo-oligosaccharides (FOS) are composed of 7 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end .

HY-N1243

Tubulysin B	Monophenols Microorganisms Classification of Application Fields Phenols Disease Research Fields Source Classification Cancer	Microtubule/Tubulin Apoptosis
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC₅₀ values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties .Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N1915

Cellohexaose	Structural Classification Polysaccharides Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite
Cellohexaose is a glucose polymer with two or more glucose monomers produced from the breakdown of cellulose, consisting of a condensation of beta (1-4) linked D-glucose monomers .

HY-N2567

(±)-Decursinol (±)-Aegelinol; (±)-Smyrinol	Infection other families Classification of Application Fields Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Bacterial
(±)-Decursinol is a potent FtsZ inhibitor. (±)-Decursinol inhibits B. anthracis FtsZ polymerization with an IC₅₀ of 102 μM .

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-N7697F

Chitobiose	Polysaccharides Microorganisms Animals Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Others
Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

HY-N6835

Fructo-oligosaccharide DP9/GF8	Polysaccharides Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Saccharum officinarum Saccharides Source Classification	Others
Fructo-oligosaccharide DP9/GF8 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=9). Fructo-oligosaccharides (FOS) are composed of 8 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end .

HY-N16025

DOPE-PEG(2000) Amine ammonium	Structural Classification Lipid	Liposome Biochemical Assay Reagents
DOPE-PEG(2000) Amine ammonium is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelle formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted agent delivery and is reactive with alkyne to form a triazole ring .

HY-Y0520R

Itaconic acid (Standard) Methylenesuccinic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite	Reference Standards Endogenous Metabolite Ferroptosis
Itaconic acid (Standard) is the analytical standard of Itaconic acid. This product is intended for research and analytical applications. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus wallichiana Zucc. Source Classification Cancer	Microtubule/Tubulin
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-113101

2-Hydroxyadipic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Hydroxyadipic acid is a dicarboxylic acid and monomer for functional polymers.2-Hydroxyadipic acid bears structural similarity to adipic acid.2-Hydroxyadipic acid forms via oxidative C-C cleavage of 2-hydroxycyclohexanone as a sustainable monomer source .

HY-N2415

Podophyllotoxone 1 Publications Verification	Classification of Application Fields Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization .

HY-N6837

Fructo-oligosaccharide DP7/GF6	Polysaccharides Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Saccharum officinarum Saccharides Source Classification	Others
Fructo-oligosaccharide DP7/GF6 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=7). Fructo-oligosaccharides (FOS) are composed of 6 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end .

HY-N0282R

Colcemid (Standard)	Alkaloids Structural Classification other families Other Alkaloids Plants Source Classification	Reference Standards Microtubule/Tubulin Apoptosis
Colcemid (Standard) is the analytical standard of Colcemid. This product is intended for research and analytical applications. Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

Cat. No.	Product Name	Chemical Structure

HY-B0015S

Paclitaxel-d5
Paclitaxel-d₅ is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization .

HY-B2227BS3

L-Lactic acid-13C-1 sodium (20% w/w in water)
L-Lactic acid- ¹³C₁ (L-E-270- ¹³C₁) sodium (20% in water) is the ¹³C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activityy .

HY-Y0520S

Itaconic acid-13C5
Itaconic acid- ¹³C₅ is the ¹³C labeled Itaconic acid. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors .

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-Y0479AS2

L-Lactate-13C sodium (20% in water) 1 Publications Verification
L-Lactate- ¹³C ((S)-2-Hydroxypropanoic acid- ¹³C) sodium is the ¹³C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .

HY-15582S

Auristatin E-d8

Auristatin E-d₈ is the deuterium labeled Auristatin E (HY-15582). Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids .

HY-W768912

Paclitaxel-13C6
Paclitaxel- ¹³C₆ is the ¹³C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy .

HY-125527S

Resolvin D1-d5

Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-N0488S

Vincristine-d3 sulfate

Vincristine-d₃ sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-B0015S1

Paclitaxel-d5 (benzoyloxy)
Paclitaxel-d₅ (benzoyloxy) is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-W062109S

Olopatadine-d6

Olopatadine-d₆ is the deuterium labeled Olopatadine. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-W012723S

2-Hydroxyethyl methacrylate-13C
2-Hydroxyethyl methacrylate- ¹³C is the ¹³C--labeled 2-Hydroxyethyl methacrylate (HY-W012723). 2-Hydroxyethyl methacrylate (HEMA) is a monomer used in the synthesis of various polymers, and the polymer PHEMA of 2-Hydroxyethyl methacrylate is widely used in the synthesis of dental composite materials .

HY-16569S

Colchicine-d6
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-16569S1

Colchicine-d3
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-W704787

Monoethyl fumarate-d5
Monoethyl fumarate-d₅ is the deuterium labeled Monoethyl fumarate (HY-W019696). Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883). Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material .

HY-N0488S2

Vincristine-d6 sulfate

Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-N0488S1

Vincristine-d3-1 sulfate

Vincristine-d₃ sulfate is the deuterium labeled Vincristine sulfate. Vincristine-1 sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine-1 sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine-1 sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine-1 sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-W002004S1

4-Amino-TEMPO-d17

4-Amino-TEMPO-d₁₇ (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d₁₇) is the deuterium labeled 4-Amino-TEMPO (HY-W002004). 4-Amino-TEMPO (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable nitroxide radical and N-nucleophile based on TEMPO. 4-Amino-TEMPO has superoxide dismutase-mimetic activity, can protect cells from oxidative damage, and has radioprotective effects. 4-Amino-TEMPO is widely used in fields such as biomedicine, materials science, and industrial production. 4-Amino-TEMPO can be used as a spin label to detect free radicals, an oxidation catalyst in industrial production, and an antioxidant stabilizer for polymers, among others .

HY-B0426AS

Olopatadine-d3 hydrochloride

Olopatadine-d₃ hydrochloride (ALO4943A-d₃) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-W728761

Voxelotor-d7
Voxelotor-d7 is the deuterium labeled Voxelotor (HY-18681). Voxelotor is a potent inhibitor of haemoglobin S (HbS) polymerization .

HY-Y0932S

Isophorone-d5
Isophorone-d₅ is the deuterium labeled Isophorone. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-Y0932S1

Isophorone-d8
Isophorone-d₈ is the deuterium labeled Isophorone . Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-18681S

Voxelotor-d6
Voxelotor-d₆ (GBT 440-d₆) is deuterium labeled Voxelotor. Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment .

HY-Y0479S3

L-Lactic acid-2-13C1
L-Lactic acid-2- ¹³C₁ is the ¹³C-labeled L-Lactic acid (HY-Y0479). L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid .

HY-107116S

MAP4343-d4
MAP4343-d₄ is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents .

HY-Y1004S6

1-Decanol-d2-2
1-Decanol-d₂-2 is deuterated labeled 1-Decanol (HY-Y1004). 1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.

HY-116852S

Thiocolchicine-d3

Thiocolchicine-d₃ is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC₅₀=2.5 μM) and competitively binds to tubulin with a K_i of 0.7 μM. Thiocolchicine induces cell apoptosis . Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

HY-W011188S

Glycidyl stearate-d5

Glycidyl stearate-d₅ is a deuterium labeled Glycidyl stearate (HY-W011188). Oxiran-2-ylmethyl stearate is a compound belonging to the class of esters. It contains reactive oxirane or epoxy groups that give the molecule its unique properties. Oxiran-2-ylmethyl stearate is derived from stearic acid and epichlorohydrin, which are naturally occurring substances. Glycidyl stearate is commonly used in various industrial applications such as the production of coatings, adhesives and surfactants. It can also be used as a crosslinking agent in the manufacture of polymers and resins.

HY-W747639

Glycidyl Stearate-13C3

Glycidyl Stearate- ¹³C₃ is ¹³C labeled Glycidyl stearate. Oxiran-2-ylmethyl stearate is a compound belonging to the class of esters. It contains reactive oxirane or epoxy groups that give the molecule its unique properties. Oxiran-2-ylmethyl stearate is derived from stearic acid and epichlorohydrin, which are naturally occurring substances. Glycidyl stearate is commonly used in various industrial applications such as the production of coatings, adhesives and surfactants. It can also be used as a crosslinking agent in the manufacture of polymers and resins .

HY-W701446

Oxiran-2-ylmethyl octadecanoate-d35

Oxiran-2-ylmethyl octadecanoate-d₃5 is the deuterium labeled Glycidyl stearate (HY-W011188). Oxiran-2-ylmethyl stearate is a compound belonging to the class of esters. It contains reactive oxirane or epoxy groups that give the molecule its unique properties. Oxiran-2-ylmethyl stearate is derived from stearic acid and epichlorohydrin, which are naturally occurring substances. Glycidyl stearate is commonly used in various industrial applications such as the production of coatings, adhesives and surfactants. It can also be used as a crosslinking agent in the manufacture of polymers and resins.

HY-B0223S4

Albendazole-d3-1

Albendazole-d₃-1 (SKF-62979-d₃-1) is the deuterium labeled Albendazole (HY-B0223). Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells .

HY-W016773S

1,10-Decanediol-d20

1,10-Decanediol-d₂₀ is the deuterium labeled 1,10-Decanediol . 1,10-Decanediol is a diol compound that can react with α-ketoglutarate (aKG) to generate polymeric microparticles (termed paKG MPs) for the sustained release of aKG, thereby promoting immunosuppressive regulation. Additionally, paKG MPs can bind to dendritic cells (DCs), reducing their glycolysis and mitochondrial respiration in vitro. These metabolic changes lead to the modulation of MHC-II and CD86 expression in DCs and alter the frequency of regulatory T cells (Tregs) as well as T-helper type 1/2/17 cells in vitro. 1,10-Decanediol can be used in research within the field of immunometabolism. can be used as a surfactant/stabilizer in the synthesis of nanomaterials .

HY-Y1010S

Oxiran-2-ylmethanol-d5

Oxiran-2-ylmethanol-d₅ is the deuterium labeled Oxiran-2-ylmethanol (Glycidol) (HY-Y1010). Oxiran-2-ylmethanol is an ester product. Oxiran-2-ylmethanol induces base pair point mutations in bacterial strains and structural chromosome aberrations in cultured cells. Oxiran-2-ylmethanol forms N-(2,3-dihydroxypropyl)valine hemoglobin adducts. Oxiran-2-ylmethanol acts as an animal carcinogen but does not significantly induce micronucleated immature erythrocytes in animal bone marrow. Oxiran-2-ylmethanol enables anionic polymerization to produce linear poly(glycidol). Oxiran-2-ylmethanol can be used for cancer-related research .

HY-W002004S

4-Amino-TEMPO-d17,15N

4-Amino-TEMPO-d₁₇, ¹⁵N (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d₁₇, ¹⁵N) is the deuterium labeled 4-Amino-TEMPO-d₁₇ (HY-W002004S1). 4-Amino-TEMPO (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable nitroxide radical and N-nucleophile based on TEMPO. 4-Amino-TEMPO has superoxide dismutase-mimetic activity, can protect cells from oxidative damage, and has radioprotective effects. 4-Amino-TEMPO is widely used in fields such as biomedicine, materials science, and industrial production. 4-Amino-TEMPO can be used as a spin label to detect free radicals, an oxidation catalyst in industrial production, and an antioxidant stabilizer for polymers, among others .

HY-B0426AS2

Olopatadine-d6 hydrochloride

Olopatadine-d₆ (ALO4943A-d₆; KW4679-d₆) hydrochloride is deuterium-labeled Olopatadine (hydrochloride) (HY-B0426A). Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-Y1004S1

1-Decanol-d2
1-Decanol-d2 is a deuterated 1-Decanol. 1-Decanol is used in the production of lubricants,?surfactants, plasticizers and?solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.

HY-W011875S

2-Isopropylthioxanthone-d7
2-Isopropylthioxanthone-d₇ is the deuterium labeled 2-Isopropylthioxanthone (HY-W011875). 2-Isopropylthioxanthone is a photoinitiator that is widely used in printing ink of packaging materials. 2-Isopropylthioxanthone triggers the radical polymerization of the acrylic component of inks, thus causing the liquid ink film to dry .

HY-Y1004S

1-Decanol-d3
1-Decanol-d3 is a deuterated 1-Decanol. 1-Decanol is used in the production of lubricants,?surfactants, plasticizers and?solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.

HY-141610S

Methyl heptanoate-d13

Methyl heptanoate-d₁₃ (Methyl enanthate-d₁₃) is the deuterium labeled Methyl heptanoate (HY-141610). Methyl heptanoate, commonly used as a flavoring and fragrance ingredient in the food and cosmetic industries, Methyl heptanoate is also used as a solvent for various substances, including resins, oils and waxes, in addition, it has been studied for its potential as a biofuel and polymer production application.

HY-W724393

Methyl heptanoate-d5

Methyl heptanoate-d₅ (Methyl enanthate-d₅) is the deuterium labeled Methyl heptanoate (HY-141610). Methyl heptanoate, commonly used as a flavoring and fragrance ingredient in the food and cosmetic industries, Methyl heptanoate is also used as a solvent for various substances, including resins, oils and waxes, in addition, it has been studied for its potential as a biofuel and polymer production application.

HY-W724293

Tetrapropylammonium-d28 chloride

Tetrapropylammonium-d₂₈ chloride is the deuterium labeled Tetrapropylammonium chloride (HY-W012412). Tetrapropylammonium chloride is a compound belonging to the class of quaternary ammonium compounds. It is a salt with cationic properties and is used in various industrial and biomedical applications. Tetrapropylammonium chloride is commonly used as a phase transfer catalyst to facilitate the movement of reactants between immiscible phases in organic synthesis reactions. It is also used as a surfactant in the formulation of personal care products, detergents, textiles and pharmaceuticals. Additionally, it is used in the production of certain types of polymers and resins.

HY-W010695S1

Cholesteryl octadecanoate-d35

Cholesteryl octadecanoate-d₃₅ is the deuterium labeled Cholesteryl stearate (HY-W010695). Cholesteryl stearate is a compound belonging to the class of esters. It is a cholesterol ester commonly found in animal and plant sources. Cholesteryl stearate consists of two naturally occurring substances, cholesteryl alcohol and stearic acid. The combination of the two creates a stable compound that is commonly used in a variety of industrial and biomedical applications. Cholesteryl stearate is commonly used as a lubricant, thickener and emollient in cosmetic formulations such as lotions and creams. It is also used to produce certain types of polymers and plastics.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15582G

Auristatin E	Microtubule/Tubulin ADC Payload	Cancer
Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor .

HY-15162G

Monomethyl auristatin E MMAE; SGD-1010; Vedotin	Microtubule/Tubulin Apoptosis ADC Payload	Cancer
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-15579BG

MMAF sodium Monomethylauristatin F sodium	Microtubule/Tubulin ADC Payload	Cancer
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-78931G

Boc-Dap-NE	ADC Linker	Cancer
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-15578G

McMMAF Maleimidocaproyl monomethylauristatin F	Drug-Linker Conjugates for ADC	Cancer
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

HY-100374G

Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-15579G

MMAF Monomethylauristatin F	Microtubule/Tubulin ADC Payload	Cancer
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

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