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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
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RAW264.7 preosteoclastic cells

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-113440
    5-Methoxytryptophol
    1 Publications Verification

    		 Melatonin Receptor ERK TNF Receptor Interleukin Related MMP Endogenous Metabolite Neurological Disease Metabolic Disease Inflammation/Immunology
    5-Methoxytryptophol is a 5-methoxyindole alcohol structurally homologous to Melatonin (HY-B0075). It is secreted by the mammalian pineal gland and exhibits an inverse circadian rhythm. 5-Methoxytryptophol regulates bone metabolism by activating the ERK1/2 pathway. It reduces the levels of pro-inflammatory cytokines TNF-α and IL-1β, as well as proteolytic enzymes MMP-1 and MMP-2, in serum and dental pulp tissues, thereby ameliorating acute pulpitis. 5-Methoxytryptophol induces rapid sleep in mice, while high doses cause respiratory depression and death. 5-Methoxytryptophol. 5-Methoxytryptophol can be used in studies related to acute pulpitis, hypnosis, and bone metabolism .
    5-Methoxytryptophol

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