1 Result for "

Rubone

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Rubone" in MCE Product Catalog:

Rubone
Rubone
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Cat. No.: HY-119833
CAS No.: 73694-15-2
Purity:  99.1%
Category:  

Flavonoids Chalcones Leguminosae Plants Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson

Target:  

MicroRNA

Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets .
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