Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson/Derris robusta Extract

Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets.

Pterocarpadiol B is a natural phenolic compound.

Pterocarpadiol Dis a6a,11b-dihydroxypterocarpanthat can be found in Derris robusta.

Pterocarpadiol C is a Flavonoids product that can be isolated from the twigs and leaves of Derris robusta..

Pterocarpadiol A is a Flavonoids product that can be isolated from the twigs and leaves of Derris robusta..

Derrisisoflavone B is a Flavonoids product that can be isolated from the herbs of Derris robusta.

6alpha-Hydroxymaackiain ((-)-6a-Hydroxymaackiain) is a Phenols product that can be isolated from the herbs of Artemisia scoparia.

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice.