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Results for "

Steroid Sulfatase

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

2

Natural
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1

Antibodies

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113293B
    Estrone sulfate sodium
    3 Publications Verification

    		 Endogenous Metabolite Estrogen Receptor/ERR Metabolic Disease Cancer
    Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate sodium is also a substrate of the OATP1B3 transporter. Estrone sulfate sodium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate sodium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate sodium is applicable to breast cancer-related research .
    Estrone sulfate sodium
  • HY-14586
    Irosustat
    1 Publications Verification

    STX64; BN83495; 667-Coumate

    		 Steroid Sulfatase Cancer
    Irosustat is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity.
    Irosustat
  • HY-14585
    Estrone O-sulfamate

    Estrone 3-O-sulfamate

    		 Steroid Sulfatase Cancer
    Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC50 values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer .
    Estrone O-sulfamate
  • HY-U00112
    Estradiol 3-sulfamate

    BLE 00084; E2MATE; ES-J 995

    		 Steroid Sulfatase Cancer
    Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
    Estradiol 3-sulfamate
  • HY-177284
    Steroid sulfatase-IN-10

    		Steroid Sulfatase Inflammation/Immunology
    Steroid sulfatase-IN-10 (Example 216) is a Steroid sulfatase inhibitor with an IC50 of 0.03-0.27 µM . Steroid sulfatase-IN-10 can be used for inflammatory diseases such as rheumatoid arthritis, type 1 and 2 diabetes and systemic lupus erythematosus research .
    Steroid sulfatase-IN-10
  • HY-144656
    Steroid sulfatase-IN-1

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 nM. Steroid sulfatase-IN-1 shows antitumor activity in vivo. Steroid sulfatase-IN-1 has the potential for the research of breast cancer .
    Steroid sulfatase-IN-1
  • HY-155234
    Steroid sulfatase-IN-6

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-6 (Compound 10c) is an irreversible inhibitor of steroid sulfatase (STS). Steroid sulfatase-IN-6 has an Ki value of 0.4 nM for human placenta STS. Steroid sulfatase-IN-6 can be used for tumor diseases research .
    Steroid sulfatase-IN-6
  • HY-151200
    Steroid sulfatase-IN-4

    		Steroid Sulfatase Endocrinology
    Steroid sulfatase-IN-4 (Compound 16) is an irreversible steroid sulfatase (STS) inhibitor with an IC50 of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis .
    Steroid sulfatase-IN-4
  • HY-151199
    Steroid sulfatase/17β-HSD1-IN-1

    		Steroid Sulfatase Endocrinology Cancer
    Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases .
    Steroid sulfatase/17β-HSD1-IN-1
  • HY-155010
    Steroid sulfatase/17β-HSD1-IN-5

    		Steroid Sulfatase Metabolic Disease
    Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research .
    Steroid sulfatase/17β-HSD1-IN-5
  • HY-151201
    Steroid sulfatase/17β-HSD1-IN-3

    		Steroid Sulfatase Cancer
    Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases .
    Steroid sulfatase/17β-HSD1-IN-3
  • HY-151202
    Steroid sulfatase/17β-HSD1-IN-4

    		Steroid Sulfatase Cancer
    Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases .
    Steroid sulfatase/17β-HSD1-IN-4
  • HY-150543
    Steroid sulfatase-IN-3

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-3 (compound 1q) is a potent STS (Steroid sulfatase) inhibitor, with an IC50 of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC50 of 1.04 µM .
    Steroid sulfatase-IN-3
  • HY-123868
    KW-2581

    		Steroid Sulfatase Cancer
    KW-2581 is a steroidal selective steroid sulfatase (STS) inhibitor with an IC50 of 4 nM. KW-2581 inhibits STS activity of ZR-75-1 cells with an IC50 of 13 nM. KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells with an IC50 of 0.18 nM. KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells both in vitro and in vivo. KW-2581 induced regression in E1S-induced tumor growth. KW-2581 can be studied in research on hormone receptors-positive breast cancer .
    KW-2581
  • HY-155233
    Steroid sulfatase-IN-5

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-5 (compound 10b) is a steroid sulfatase (STS) inhibitor (IC50: 0.32 nM). Steroid sulfatase-IN-5 inhibits T-47D cell proliferation with an IC50 of 35.7 μM. Steroid sulfatase-IN-5 can be used for research of breast cancer .
    Steroid sulfatase-IN-5
  • HY-172605
    Steroid sulfatase-IN-9

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-9 (compound 54E) is a steroid sulfatase (STS) inhibitor with the inhibition rates of 87.03% at 10 μM. Steroid sulfatase-IN-9 shows no detectable toxic effects in zebrafish larvae model .
    Steroid sulfatase-IN-9
  • HY-150542
    Steroid sulfatase-IN-2

    		Steroid Sulfatase Cancer
    Steroid sulfatase -IN-2 is an active steroid sulfatase (STS) inhibitor with an IC50 value of 109.5 nM. Steroid sulfatase-IN-2 can be used for the research of hormone-dependent cancers, such as estrogen-dependent breast and endometrial cancer .
    Steroid sulfatase-IN-2
  • HY-155235
    Steroid sulfatase-IN-7

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-7 is an irreversible steroid sulfatase (STS) inhibitor with an IC50 value of 0.05 nM against human placental STS and can be used in cancer research .
    Steroid sulfatase-IN-7
  • HY-156902
    Steroid sulfatase-IN-8

    		Steroid Sulfatase Others
    Steroid sulfatase-IN-8 (7) is a STS inhibitor with PM IC50 value of 1 nM, JEG-3 IC50 of 0.025 nM, respecively .
    Steroid sulfatase-IN-8
  • HY-181408
    Steroid sulfatase-IN-11

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-11 is a steroid sulfatase inhibitor, which functionally inhibits steroid sulfatase activity, reducing the enzyme's ability to hydrolyze steroid sulfates. Steroid sulfatase-IN-11 can be used for the research of hormone-dependent cancers .
    Steroid sulfatase-IN-11
  • HY-182755
    Steroid sulfatase-IN-12

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-12 is a steroid sulfatase inhibitor. Steroid sulfatase-IN-12 inhibits the activity of steroid sulfatase. Steroid sulfatase-IN-12 can be used in research related to hormone receptor-positive/HER2-negative breast cancer .
    Steroid sulfatase-IN-12
  • HY-113293BR
    Estrone sulfate sodium (Standard)

    		Reference Standards Endogenous Metabolite Estrogen Receptor/ERR Metabolic Disease Cancer
    Estrone sulfate sodium (Standard) is the analytical standard of Estrone sulfate sodium (HY-113293B). This product is intended for research and analytical applications. Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate sodium is also a substrate of the OATP1B3 transporter. Estrone sulfate sodium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate sodium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate sodium is applicable to breast cancer-related research.
    Estrone sulfate sodium (Standard)
  • HY-123773
    SR-16157

    NSC 732011; HLX-801

    		 Steroid Sulfatase Estrogen Receptor/ERR Cancer
    SR-16157 (NSC 732011; HLX-801) is a dual-action steroid sulfatase (STS) inhibitor (IC50 = 0.1 uM) and selective ERα modulator. SR-16157 exhibits STS inhibitory and anti-estrogenic effects in breast cancer cells. SR-16157 may be used in breast cancer research .
    SR-16157
  • HY-116377
    DU-14

    		Steroid Sulfatase Neurological Disease
    DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity .
    DU-14
  • HY-181163
    Caspase-3/7 activator 4

    		Caspase COX Cytochrome P450 Steroid Sulfatase Apoptosis Cancer
    Caspase-3/7 activator 4 is a caspase-3 activator and caspase-7 activator. Caspase-3/7 activator 4 inhibits key enzymes in estrogen biosynthesis, including aromatase (IC50 = 38.3 nM) and steroid sulfatase (IC50 = 12.7 µM), and selectively suppresses COX-2 (IC50 = 5.38 µM). Caspase-3/7 activator 4 shows strong antioxidant activity (DPPH: IC50 = 16.26 µM). Caspase-3/7 activator 4 inhibits estrogen synthesis, suppresses estrogen availability, reduces prostaglandin production, increases caspase-3/7 expression, induces G0/G1 cell cycle arrest, induces apoptotic cell death, reduces circulating TNF-α and VEGFR-II levels, restores hepatorenal function markers and histoarchitecture, restores antioxidant defense enzyme activity, reduces lipid peroxidation, exerts antiproliferative activity against breast cancer cells, exerts antitumor activity in the Ehrlich ascites carcinoma models. Caspase-3/7 activator 4 can be used for the research of breast cancer, ehrlich ascites carcinoma .
    Caspase-3/7 activator 4

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