Steroid sulfatase/17β-HSD1-IN-3
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases.
For research use only. We do not sell to patients.
- CAS No.: 2990549-76-1
- Formula: C19H17ClN2O5S
- Molecular Weight:420.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 27 nM (hSTS)[1].
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) (0-1100 nM, 24 h) inhibits human steroid sulfatase (hSTS) with an IC50 value of 27 nM and acts on irreversible inhibition of hSTS with an IC50 value of 29 nM in T47D human breast cancer cells[1].
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) (20 μM, 48 h) inhibits HEK-293 cells growth by 30% at a concentration of 20 μM with low cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2990549-76-1
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Molecular Weight 420.87
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Formula C19H17ClN2O5S
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SMILES
O=S(OC1=CC=C(C2=CC=C(C(N(C)C3=CC=CC=C3C)=O)O2)C(Cl)=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Steroid sulfatase/17β-HSD1-IN-3 Related Classifications
HY-151201 Related Classifications
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