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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
TMPA
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "TMPA" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-18555
CAS No.: 1258275-73-8
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TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation .
Cat. No.: HY-RS17596
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Tpm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tpm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-D3080
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CR-1 is a ratiometric photoacoustic (PA) probe for in-situ real-time imaging of Zn 2+ in deep living tissues. CR-1 is formed by coupling the near-infrared cyanine dye IR825 with the Zn 2+ ligand tris (2-pyridylmethyl) amine (TMPA). Upon binding to Zn 2+, the five N atoms on TMPA coordinate with Zn 2+, leading to double bond rearrangement of IR825 and attenuation of its π-electron conjugated system. The absorption peak of CR-1 blue-shifts from 710 nm to 532 nm, enabling quantitative detection of Zn 2+ via the PA532/PA710 ratio. Free CR-1 generates a strong PA signal at 710 nm, while CR-1 bound to Zn 2+ produces a strong PA signal at 532 nm .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
