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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
TNF receptor 1
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "TNF receptor 1" in MCE Product Catalog:
8
8 Publications Verification
Target:
Research Areas:
SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .
8
8 Publications Verification
Target:
Research Areas:
SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .
5
5 Cited Publications
Target:
Research Areas:
JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 μM) and reduces TNF levels (EC50=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases .
3
3 Cited Publications
Target:
Research Areas:
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor .
3
3 Cited Publications
Research Areas:
RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages .
1
1 Cited Publications
Target:
Histamine Receptor Macrophage migration inhibitory factor (MIF) VEGFR Akt Interleukin Related
Research Areas:
Carebastine is an Ebastine (HY-B0674) metabolite and H1-receptor antagonist. Carebastine inhibits VEGFR-2 and Akt phosphorylation. Carebastine exerts an anti-inflammatory effect by inhibiting MIF as well as TNF-α and IL-6 production. Carebastine shows anti-angiogenic activity
Cat. No.: HY-P11108
CAS No.: 1895883-60-9
Target:
Research Areas:
Research Areas:
CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases .
Cat. No.: HY-P11108A
Target:
Research Areas:
Cat. No.: HY-175813
CAS No.: 3113770-74-1
Research Areas:
NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis .
Cat. No.: HY-172409
Target:
Research Areas:
CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models .
Cat. No.: HY-122566
CAS No.: 903864-87-9
Synonyms: ZINC666243
Target:
Research Areas:
SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer. It induces NF-κB signaling in cells expressing human TLR2 (EC50=0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.
Cat. No.: HY-P7305
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor receptor Superfamily Member 1A; Tumor Necrosis Factor receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:
Human
Source:
CHO
Cat. No.: HY-P70801
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor receptor Superfamily Member 1A; Tumor Necrosis Factor receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:
Human
Source:
E. coli
Cat. No.: HY-P72443
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor receptor Superfamily Member 1A; Tumor Necrosis Factor receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P73449
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor receptor Superfamily Member 1A; Tumor Necrosis Factor receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73450
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor receptor Superfamily Member 1A; Tumor Necrosis Factor receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74504
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor receptor Superfamily Member 1A; Tumor Necrosis Factor receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:
Rat
Source:
HEK293
Cat. No.: HY-P74505
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor receptor Superfamily Member 1A; Tumor Necrosis Factor receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:
Rat
Source:
HEK293
Cat. No.: HY-P700263
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor receptor Superfamily Member 1A; Tumor Necrosis Factor receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
