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Results for "

TNF receptor 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (7) Akt (1) Apoptosis (2) Cannabinoid Receptor (1) Caspase (2) Complement System (1) G protein-coupled Bile Acid Receptor 1 (1) Histamine Receptor (1) Interleukin Related (2) Leukotriene Receptor (1) Macrophage migration inhibitory factor (MIF) (1) Neuropeptide S Receptor (1) NF-κB (3) p38 MAPK (1) Prostaglandin Receptor (1) Toll-like Receptor (TLR) (1) Trace Amine-associated Receptor (TAAR) (1) VEGFR (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (1)

By Targets:

TNF Receptor (7)

Akt (1)

Apoptosis (2)

Cannabinoid Receptor (1)

Caspase (2)

Complement System (1)

G protein-coupled Bile Acid Receptor 1 (1)

Histamine Receptor (1)

Interleukin Related (2)

Leukotriene Receptor (1)

Macrophage migration inhibitory factor (MIF) (1)

Neuropeptide S Receptor (1)

NF-κB (3)

p38 MAPK (1)

Prostaglandin Receptor (1)

Toll-like Receptor (TLR) (1)

Trace Amine-associated Receptor (TAAR) (1)

VEGFR (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (1)

Endocrinology (1)

Inflammation/Immunology (9)

Metabolic Disease (1)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Targets Recommended: TNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111255

SPD304 Maximum Cited Publications 7 Publications Verification	TNF Receptor	Cancer
SPD304 is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

HY-128686

KAG-308 3 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a K_i and an EC₅₀ of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor .

HY-121356

Carebastine 1 Publications Verification	Histamine Receptor Macrophage migration inhibitory factor (MIF) VEGFR Akt Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Carebastine is an Ebastine (HY-B0674) metabolite and *H1-receptor* antagonist. Carebastine inhibits VEGFR-2 and Akt phosphorylation. Carebastine exerts an anti-inflammatory effect by inhibiting MIF as well as *TNF-α* and IL-6 production. Carebastine shows anti-angiogenic activity

HY-111255A

SPD304 dihydrochloride Maximum Cited Publications 7 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
SPD304 dihydrochloride is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

HY-P11108

RP-182	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research .

HY-12700

RO5256390 3 Publications Verification	Trace Amine-associated Receptor (TAAR)	Neurological Disease
RO5256390 is an orally effective *trace amine associated receptor 1* (TAAR1)** agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages .

HY-148141

JPE-1375 4 Publications Verification	Complement System	Inflammation/Immunology
JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC₅₀=6.9 μM) and reduces *TNF* levels (EC₅₀=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases .

HY-147086

CAY10789	Leukotriene Receptor G protein-coupled Bile Acid Receptor 1 TNF Receptor	Metabolic Disease Inflammation/Immunology
CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC₅₀=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC₅₀=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases .

HY-P11108A

RP-182 acetate	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research .

HY-175813

NPSR1 antagonist-1	Neuropeptide S Receptor Interleukin Related TNF Receptor	Inflammation/Immunology
NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis .

HY-172409

CB1R antagonist 2	Cannabinoid Receptor p38 MAPK NF-κB	Inflammation/Immunology
CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models .

HY-122566

SMU127 ZINC666243	Toll-like Receptor (TLR) TNF Receptor	Cancer
SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer. It induces NF-κB signaling in cells expressing human TLR2 (EC₅₀=0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

Cat. No.	Product Name	Target	Research Area

HY-P11108

RP-182	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research .

HY-P11108A

RP-182 acetate	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research .

Species:	Human (3)
Tag:	His (2) Fc (1)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70801

	TNF RI/TNFRSF1A Protein, Human (His) Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; TNFAR; TNFR1	Human	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Human (His) is expressed by E. coli with a 6*His tag at the N-terminus.

HY-P70815

	TNFRSF10C Protein, Human (HEK293, His) Tumor Necrosis Factor receptor Superfamily Member 10C; Antagonist Decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor Without Death Domain; Decoy receptor 1; DcR1; Lymphocyte Inhibitor of TRAIL; TNF-Related Apoptosis-Inducing Ligand receptor 3; TRAIL receptor	Human	HEK293
	The TNFRSF10C protein is a receptor for TRAIL and lacks a cytoplasmic death domain, making it unable to induce apoptosis. Instead, it protects cells by competing for ligand binding with TRAIL-R1 and R2, acting as a decoy receptor and mitigating TRAIL-mediated apoptosis. TNFRSF10C Protein, Human (HEK293, His) is the recombinant human-derived TNFRSF10C protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704931

	TNFRSF10C Protein, Human (HEK293, Fc) Tumor Necrosis Factor receptor Superfamily Member 10C; Antagonist Decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor Without Death Domain; Decoy receptor 1; DcR1; Lymphocyte Inhibitor of TRAIL; TNF-Related Apoptosis-Inducing Ligand receptor 3; TRAIL receptor	Human	HEK293

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (1) Mouse (1)
Application:	IHC-P (1) ICC/IF (2) IP (1) WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (2)
Modification:	Unmodified (1)

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HY-P87404A

	DR4/TNFRSF10A Antibody (YA7092)(PBS only) CD261, APO2, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1	WB, ICC/IF, FC	Human
	DR4/TNFRSF10A Antibody (YA7092) is a Rabbit-derived and non-conjugated IgG Recombinant monoclonal antibody, targeting to DR4/TNFRSF10A.

HY-P810754

	DcR1 Antibody (YA9997) CD263, DCR1, LIT, TRAILR3, TRID, UNQ321/PRO366, TNFRSF10C, Tumor necrosis factor receptor superfamily member 10C, Antagonist decoy receptor for TRAIL/Apo-2L, Decoy TRAIL receptor without death domain, Decoy receptor 1, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor without an intracellular domain, DcR1, TRAIL receptor 3, TRAIL-R3	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	DcR1 Antibody (YA9997) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to DcR1.

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