1043495-96-0
Chemical Structure
RO5256390
- CAS No.: 1043495-96-0
- Formula:C13H18N2O
- Molecular Weight:218.30
IUPAC Name: (S)-4-((S)-2-phenylbutyl)-4,5-dihydrooxazol-2-amine
InChIKey: IXDKFUBXESWHSL-JQWIXIFHSA-N
SMILES: NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1
Biological Activity: RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages[1][2][3].
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RO5256390 | 98.75% | RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages. | ||||||||||||||||||||
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References
- [1]. Barnes DA, et al. TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages. J Neuroimmune Pharmacol. 2023 Jun;18(1-2):100-111. [Content Brief]
- [2]. Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470. [Content Brief]
- [3]. Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18(5):543-56. [Content Brief]
